Results 231 to 240 of about 15,372,764 (357)

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source

Adipose immune microenvironment: catalyst of age-related adipose tissue dysfunction. [PDF]

Immun Ageing
Song Y, Xing H, Luo Y, Li B, Li Y, Dong Z.   +5 more
europepmc   +1 more source

Age should not be a barrier for pulmonary endarterectomy in carefully selected patients [PDF]

, 2017
Michael Newnham, Jules Hernández‐Sánchez, John Dunning, Choo Ng, Steven Tsui, Katherine Bunclark, Karen Sheares, Dolores Taboada, Mark Toshner, Joanna Pepke‐Żaba, David P. Jenkins, John Cannon   +11 more
openalex   +1 more source

Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

Nature, 2019
Nalle Pentinmikko, Sharif Iqbal, Miyeko D. Mana, S. Andersson, A. Cognetta, R. Suciu, Jatin Roper, Kalle Luopajärvi, Eino Markelin, S. Gopalakrishnan, Olli-Pekka Smolander, S. Naranjo, Tuure Saarinen, A. Juuti, K. Pietiläinen, P. Auvinen, A. Ristimäki, Nitin Gupta, T. Tammela, T. Jacks, D. Sabatini, B. Cravatt, Ömer H. Yilmaz, P. Katajisto   +23 more
semanticscholar   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Single-cell mapping reveals age-related alterations in periosteal progenitor cells and immune microenvironment. [PDF]

Cell Regen
Zhao L, Wu C, Chen K, Xu Z, You Y, Zhao P, Zhu D, Su M, Luo J, Wang Y.   +9 more
europepmc   +1 more source

Interaction between Age and Obesity on Cardiomyocyte Contractile Function: Role of Leptin and Stress Signaling

, 2010
Jun Ren, Feng Dong, Guojun Cai, Peng Zhao, Jennifer M. Nunn, Loren E. Wold, Jianming Pei   +6 more
openalex   +2 more sources

SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes [PDF]

, 2019
Georg Auburger, Suzana Gispert, Sylvia Torres-Odio, Marina Jendrach, Nadine Brehm, Júlia Canet-Pons, Jana Key, Nesli-Ece Şen   +7 more
openalex   +1 more source

Changes over 6 years in secondary health conditions and activity limitations in older adults aging with long‐term spinal cord injury

, 2022
Mikael Waller, Sophie Jörgensen, Jan Lexell   +2 more
openalex   +1 more source

Key role for inhibins in effective T cell activation, migration and Th17 differentiation

FEBS Open Bio, EarlyView.
Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco, Roxana Olguín‐Alor, Lizbeth Bolaños‐Castro, Alexandra Morales‐Cruz, Marisol De La Fuente‐Granada, Gloria Soldevila   +5 more
wiley   +1 more source