Results 111 to 120 of about 474,048 (356)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The role of the microbiota in sedentary lifestyle disorders and ageing: lessons from the animal kingdom [PDF]

, 2020
Paul W. O’Toole, Paul G. Shiels
openalex   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Mitochondrial and metabolic dysfunction in ageing and age-related diseases

Nature Reviews Endocrinology, 2022
J. Amorim, G. Coppotelli, A. Rolo, C. Palmeira, J. M. Ross, D. Sinclair   +5 more
semanticscholar   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Healthcare workers’ experience of screening older adults in emergency care settings: a qualitative descriptive study using the Theoretical Domains Framework

BMC Geriatrics
Background In emergency care settings, screening for disease or risk factors for poor health outcomes among older adults can identify those in need of specialist and early intervention.
Louise Barry, Aoife Leahy, Margaret O’Connor, Damien Ryan, Gillian Corey, Sylvia Murphy Tighe, Rose Galvin, Pauline Meskell   +7 more
doaj   +1 more source

The Impact of Serious Games on Physical Activity, Cognitive Training and Mental Health for the Ageing Population During COVID-19: Implications and Future Trajectories [PDF]

, 2022
Sum-Yuet Joyce Lau, Balasankar Ganesan, Kenneth N. K. Fong   +2 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

AN EXPLORATION OF THE INFORMATION AND SUPPORT NEEDS OF CARERS OF PEOPLE LIVING WITH DEMENTIA AND INCONTINENCE

Continence, 2023
J Ostaszkiewicz, J Cecil, E Watt
doaj   +1 more source

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration

Lancet Neurology, 2013
J. Wardlaw, Eric E. Smith, G. Biessels, C. Cordonnier, F. Fazekas, R. Frayne, R. Lindley, J. O'Brien, F. Barkhof, O. Benavente, S. Black, C. Brayne, M. Breteler, H. Chabriat, C. DeCarli, F. de Leeuw, F. Doubal, Marco Duering, Nick C Fox, S. Greenberg, V. Hachinski, I. Kilimann, V. Mok, R. V. Oostenbrugge, L. Pantoni, O. Speck, B. Stephan, S. Teipel, A. Viswanathan, D. Werring, Christopher L H Chen, Colin Smith, M. van Buchem, B. Norrving, P. Gorelick, M. Dichgans   +35 more
semanticscholar   +1 more source