Results 111 to 120 of about 929,250 (364)

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Validation of Automated White Matter Hyperintensity Segmentation

Journal of Aging Research, 2011
Introduction. White matter hyperintensities (WMHs) are a common finding on MRI scans of older people and are associated with vascular disease. We compared 3 methods for automatically segmenting WMHs from MRI scans. Method.
Sean D. Smart, Michael J. Firbank, John T. O'Brien   +2 more
doaj   +1 more source

Pediatric hospitalizations associated with respiratory syncytial virus (RSV) and influenza, and the frequency of asthma as a secondary diagnosis [PDF]

arXiv, 2017
Background: There is uncertainty about the burden of severe outcomes associated with RSV and influenza in children. Methods: We have applied previously developed methodology to estimate the rates of influenza and RSV-associated hospitalizations with different diagnoses in different age subgroups of US children between the 2003-04 through the 2009-10 ...
arxiv  

Cytogerontology since 1881: A reappraisal of August Weismann and a review of modern progress [PDF]

, 1982
Cytogerontology, the science of cellular ageing, originated in 1881 with the prediction by August Weismann that the somatic cells of higher animals have limited division potential.
A Carrel, A Comfort, A Götte, A Weismann, A Weismann, A Weismann, A Weismann, A Weismann, A Weismann, AH Ebeling, AJ Nienhaus, AL Muggleton-Harris, AO Martinez, AR Sheldrake, AR Williamson, B Charlesworth, B Hill, BL Strehler, C Darwin, C Zavala, CB Harley, CB Harley, CH Evans, CJ Epstein, CL Bunn, CM Child, CM Child, CS Minot, CW Daniel, D Harman, D Kram, D Lack, DA Ogden, DE Brash, E Bell, E Metchnikoff, E Stecker, EL Schneider, F Vogel, FM Burnet, GA Sacher, GC Williams, GH Stein, GJ Todaro, GM Martin, GM Martin, GM Martin, GM Martin, GM Martin, GP Bidder, GR Martin, HE Swim, HEM Kay, HJ Curtis, HR Hirsch, HW Woolhouse, I Zs-Nagy, J Bjorksten, J Maynard Smith, J Maynard Smith, J Ponten, J Smith-Sonneborn, JA Witkowski, JBS Haldane, JF Stanley, JR Smith, JR Smith, JR Smith, K Illmensee, K Kontermann, KH Rothfels, L Hayflick, L Hayflick, L Hayflick, L Szilard, LC Cole, LC Stevens, LE Orgel, LE Orgel, MR Rose, P Calow, PB Medawar, PB Medawar, PL Krohn, R Holliday, R Holliday, R Holliday, R Holliday, R Holliday, R Holliday, R Holliday, R Long De, R Pearl, R Rosenberger, RD Guthrie, RG Cutler, RG Cutler, RW Hart, S Linn, SH Vines, SJ Fulder, T Cremer, TBL Kirkwood, TBL Kirkwood, TBL Kirkwood, TBL Kirkwood, TBL Kirkwood, Thomas B. L. Kirkwood, Thomas Cremer, TM Sonneborn, TM Sonneborn, W Topp, WD Hamilton, ZhA Medvedev, ZhA Medvedev   +114 more
core   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Ageing, plasticity, and cognitive reserve in connectionist networks [PDF]

, 2008
Neurocomputational modeling has suggested that a range of mechanisms can lead to reductions in functional plasticity across development (Thomas & Johnson, 2006).
Thomas, Michael S.C.
core   +1 more source

Ageing Policies in Slovenia: Before and After "Austerity" [PDF]

, 2017
Similarly, to other European countries, Slovenia is facing ageing of the population. The European Year for Active Ageing and Solidarity between Generations in 2012 and the recent economic crisis have influenced social policy in the area of ageing and ...
Hlebec, Valentina, Rakar, Tatjana
core   +2 more sources

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain

Acta Neuropathologica Communications, 2019
Hexanucleotide repeat expansions of variable size in C9orf72 are the most prevalent genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia.
Javier Morón-Oset, Tessa Supèr, Jacqueline Esser, Adrian M. Isaacs, Sebastian Grönke, Linda Partridge   +5 more
doaj   +1 more source