Results 201 to 210 of about 474,048 (356)

Age Integration or Age Conflict as Society Ages? [PDF]

The Gerontologist, 2000
openaire   +2 more sources

Functional, Structural and Proteomic Effects of Ageing in Resistance Arteries [PDF]

Lars Jørn Jensen
openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Careful validation of brain age estimators: thinking bigger. [PDF]

EBioMedicine
Carmichael O.
europepmc   +1 more source

Environmental and chemical ageing of epoxy resins cured with bio-based amino acids

Walter, Melissa, Gibhardt, Dennis, Fiedler, Bodo   +2 more
openalex   +1 more source

PGC‐1α regulates the interplay between oxidative stress, senescence and autophagy in the ageing retina important in age‐related macular degeneration [PDF]

Iswariyaraja Sridevi Gurubaran, Cezary Watała, Joanna Kostanek, Joanna Szczepańska, Elżbieta Pawłowska, Kai Kaarniranta, Janusz Błasiak   +6 more
openalex   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Bringing together clinical and physical sciences to deliver translational ageing research: the UK experience. [PDF]

BMC Proc
Steell L, Hinchliffe C, Cooper R, Witham MD.   +3 more
europepmc   +1 more source

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Nature reviews. Drug discovery, 2020
S. Cunnane, E. Trushina, C. Morland, A. Prigione, G. Casadesus, Z. Andrews, M. Beal, L. Bergersen, R. Brinton, S. Monte, A. Eckert, J. Harvey, R. Jeggo, J. Jhamandas, O. Kann, Clothide Mannoury la Cour, William F. Martin, G. Mithieux, P. Moreira, M. Murphy, K. Nave, Tal Nuriel, Stéphane H. R. Oliet, Stéphane H. R. Oliet, Frédéric Saudou, Frédéric Saudou, M. Mattson, R. Swerdlow, M. Millan   +28 more
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source