Results 211 to 220 of about 998,871 (360)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Epigenetic clocks: advancing biological age measures towards meaningful clinical use. [PDF]

EBioMedicine
eBioMedicine.
europepmc   +1 more source

eLife Assessment: Neural evidence of functional compensation for fluid intelligence in healthy ageing

Björn Herrmann
openalex   +1 more source

Knowledge, stereotyping and attitudes towards self ageing [PDF]

, 2002
Lindsay Getting, Judith Fethney, Kevin McKee, Margaret Churchward, Marilyn Goff, Slade Matthews   +5 more
openalex   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Typology of ageing and its associations with the end of life and death among older adults in China: a longitudinal person-centred study. [PDF]

BMJ Open
Li J, Song L.
europepmc   +1 more source

The Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing (IDS-TILDA) Wave 2, loneliness consequences supporting data, 2014

IDS-TILDA
openalex   +1 more source

Association among ageing‐related stereotypic beliefs, self‐efficacy and health‐promoting behaviors in elderly Korean adults [PDF]

, 2013
Hyun‐E Yeom
openalex   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Testicular ageing as a central hallmark of male senescence: characteristics, molecular mechanisms and emerging therapeutic strategies. [PDF]

Ann Med
Gao J, Wang L, Li W, Liu W.
europepmc   +1 more source