Results 251 to 260 of about 929,250 (364)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Aging

Experimental Animals, 2021
openaire   +3 more sources

Impact of Rural Ageing on Non-Grain Agricultural Production in China: An Analysis Based on Food Security Strategy. [PDF]

Foods
Guo Y, Tian Y.
europepmc   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Effects of Si, Cu, Fe, Mn and Cr on the ageing characteristics of Al-Zn-Mg alloys

, 1967
Sang Gun CHOE
openalex   +2 more sources

Ageing, recognition and partial learning [PDF]

, 1967
James Hartley, Iain S. Marshall
openalex   +1 more source

Neurophysiological signatures of ageing: compensatory and compromised neural mechanisms. [PDF]

Brain Commun
Ranasinghe KG, Kudo K, Casaletto K, Rojas-Martinez JC, Syed F, Vossel K, Miller BL, Rabinovici GD, Kramer JH, Rankin KP, Nagarajan SS.   +10 more
europepmc   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

The Solid Solubility of the α-Phase in an Al-Mg Alloy Containing 0.5 wt%Ag and the Ageing Phenomena

, 1969
Tadao Ito, Tadashi Furuya, Keisuke Matsuura, Katsuya Watanabe   +3 more
openalex   +2 more sources

Anti-ageing activities of nanovesicles derived from <i>Artemisia</i> princeps in human dermal cells and human skin model. [PDF]

J Extracell Biol
Kim K, Sohn Y, Yeon JH.
europepmc   +1 more source