Results 61 to 70 of about 929,250 (364)
Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals
Nature Communications, 2016 Removal of the C. elegans germline substantially increases organismal lifespan. Here, Nakamura et al. show that the transcription factors MML-1 and MXL-2 coordinate this process in that they reduce TOR signalling and increase autophagy by regulating ...
Shuhei Nakamura +9 more
doaj +1 more source
Immunity & Ageing, 2008 On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related Diseases was held in Palermo, Italy. The lecture of D. Mari on Hemostasis and ageing is summarized herein. Physiological ageing is associated with increased plasma levels of many proteins of blood coagulation together with fibrinolysis impairment. This may be of great concern in
D. Mari +5 more
openaire +5 more sources
FEBS Letters, Volume 599, Issue 7, Page 1055-1074, April 2025.Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard +7 more
wiley +1 more source
The Relationship Between Personality Traits of Older Adults and Elder Abuse
Sālmand, 2023 Objectives This study aims to investigate the relationship between the big-five personality traits (extroversion, neuroticism, agreeableness, conscientiousness, and openness to experience) and elder abuse.
Mina Rahimzade Sani +3 more
doaj
Morphology and mechanical properties of nanocrystalline Cu/Ag alloy [PDF]
, 2017 Hybrid Monte Carlo (MC)/molecular dynamics (MD) simulations are conducted to study the microstructures of nanocrystalline (nc) Cu/Ag alloys with various Ag concentrations. When the Ag concentration is below 50 Ag atoms/nm!, an increase in Ag concentration leads to a gradual growth of monolayer grain boundary (GB) complexions into nanolayer complexions.
arxiv +1 more source
, 2007 Cutaneous ageing manifests itself as a progressive reduction in maximum function and reserve capacity of skin tissue. It is not a unique and uniform biological event. Skin comprises three layers: epidermis, dermis and subcutaneous tissue.
Brincat, Mark P. +2 more
core +1 more source
FEBS Letters, Volume 599, Issue 6, Page 901-911, March 2025.The human Na+/H+ antiporter NHA2 transports Na+ or Li+ in exchange for protons across cell membranes, and its dysfunction results in various pathologies, e.g., fertility disorders, hypertension, or diabetes. This work provides the molecular characterization of interactions of NHA2 with its specific inhibitor phloretin, which can be helpful for the ...
Olga Zimmermannova +3 more
wiley +1 more source
Sex-specific effects of Cre expression in Syn1Cre mice
Scientific Reports, 2023 The Cre-loxP system has been used to generate cell-type specific mutations in mice, allowing researchers to investigate the underlying biological mechanisms of disease.
Maarouf Baghdadi +3 more
doaj +1 more source
FEBS Letters, Volume 599, Issue 7, Page 1075-1085, April 2025.We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti +2 more
wiley +1 more source
International Journal of Population Data ScienceIntroduction Accurate identification of Aged Care residents accessing hospital services is challenging due to multiple hospital Electronic Health Record (EHR) systems and entry points resulting in inconsistent addresses and coding.
Tanya Ravipati +6 more
doaj +1 more source