Results 41 to 50 of about 938,839 (307)

Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals

Nature Communications, 2016
Removal of the C. elegans germline substantially increases organismal lifespan. Here, Nakamura et al. show that the transcription factors MML-1 and MXL-2 coordinate this process in that they reduce TOR signalling and increase autophagy by regulating ...
Shuhei Nakamura, Özlem Karalay, Philipp S. Jäger, Makoto Horikawa, Corinna Klein, Kayo Nakamura, Christian Latza, Sven E. Templer, Christoph Dieterich, Adam Antebi   +9 more
doaj   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Cytogerontology since 1881: A reappraisal of August Weismann and a review of modern progress [PDF]

, 1982
Cytogerontology, the science of cellular ageing, originated in 1881 with the prediction by August Weismann that the somatic cells of higher animals have limited division potential.
A Carrel, A Comfort, A Götte, A Weismann, A Weismann, A Weismann, A Weismann, A Weismann, A Weismann, AH Ebeling, AJ Nienhaus, AL Muggleton-Harris, AO Martinez, AR Sheldrake, AR Williamson, B Charlesworth, B Hill, BL Strehler, C Darwin, C Zavala, CB Harley, CB Harley, CH Evans, CJ Epstein, CL Bunn, CM Child, CM Child, CS Minot, CW Daniel, D Harman, D Kram, D Lack, DA Ogden, DE Brash, E Bell, E Metchnikoff, E Stecker, EL Schneider, F Vogel, FM Burnet, GA Sacher, GC Williams, GH Stein, GJ Todaro, GM Martin, GM Martin, GM Martin, GM Martin, GM Martin, GP Bidder, GR Martin, HE Swim, HEM Kay, HJ Curtis, HR Hirsch, HW Woolhouse, I Zs-Nagy, J Bjorksten, J Maynard Smith, J Maynard Smith, J Ponten, J Smith-Sonneborn, JA Witkowski, JBS Haldane, JF Stanley, JR Smith, JR Smith, JR Smith, K Illmensee, K Kontermann, KH Rothfels, L Hayflick, L Hayflick, L Hayflick, L Szilard, LC Cole, LC Stevens, LE Orgel, LE Orgel, MR Rose, P Calow, PB Medawar, PB Medawar, PL Krohn, R Holliday, R Holliday, R Holliday, R Holliday, R Holliday, R Holliday, R Holliday, R Long De, R Pearl, R Rosenberger, RD Guthrie, RG Cutler, RG Cutler, RW Hart, S Linn, SH Vines, SJ Fulder, T Cremer, TBL Kirkwood, TBL Kirkwood, TBL Kirkwood, TBL Kirkwood, TBL Kirkwood, Thomas B. L. Kirkwood, Thomas Cremer, TM Sonneborn, TM Sonneborn, W Topp, WD Hamilton, ZhA Medvedev, ZhA Medvedev   +114 more
core   +1 more source

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

Aging

, 2018
This chapter reviews studies that have examined age-related anatomic and functional changes in sensory, neuromuscular, and cognitive systems that impair the control of balance and gait. Specifically, we examine age-related changes in peripheral systems: lower-limb sensation, visual functions such as contrast sensitivity and depth perception, vestibular
Lord, SR, Delbaere, K, Sturnieks, DL
openaire   +3 more sources

Healthy ageing: ageing safely [PDF]

European Heart Journal Supplements, 2001
The population of the developed world is steadily ageing. In the European Union, approximately 22% of persons are over 60 years of age and this is projected to increase to more than 27% by the year 2020. This has major implications for health care resources and the productive workforce. Ageing is accompanied by a decline in the physiological reserve of
openaire   +2 more sources

Ageing Policies in Slovenia: Before and After "Austerity" [PDF]

, 2017
Similarly, to other European countries, Slovenia is facing ageing of the population. The European Year for Active Ageing and Solidarity between Generations in 2012 and the recent economic crisis have influenced social policy in the area of ageing and ...
Hlebec, Valentina, Rakar, Tatjana
core   +2 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

The Relationship Between Personality Traits of Older Adults and Elder Abuse

Sālmand, 2023
Objectives This study aims to investigate the relationship between the big-five personality traits (extroversion, neuroticism, agreeableness, conscientiousness, and openness to experience) and elder abuse.
Mina Rahimzade Sani, Yadollah Abolfathi Momtaz, Mahshid Foroughan, Nasibeh Zanjari   +3 more
doaj  

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source