Results 41 to 50 of about 723,040 (308)
Cells, 2021 Metastasis Associated Lung Adenocarcinoma Transcript-1 (MALAT1) is implicated in regulating the inflammatory response and in the pathology of several chronic inflammatory diseases, including osteoarthritis (OA).
Fawzeyah A. Alnajjar +7 more
doaj +1 more source
The gut microbiome as a modulator of healthy ageing
Nature reviews: Gastroenterology & hepatology, 2022 The gut microbiome is a contributory factor in ageing-related health loss and in several non-communicable diseases in all age groups. Some age-linked and disease-linked compositional and functional changes overlap, while others are distinct.
T. Ghosh, F. Shanahan, P. O'Toole
semanticscholar +1 more source
The ageing workforce? Separating fact from hype [PDF]
, 2004 This article explains that much of the hype about workforce ageing in Australia is either exaggerated or plainly wrong. It is true that the workforce is ageing, as is our society generally.
Doughney, James
core +3 more sources
The longitudinal progression of autonomic dysfunction in Parkinson's disease: A 7-year study
Frontiers in Neurology, 2023 BackgroundAutonomic dysfunction, including gastrointestinal, cardiovascular, and urinary dysfunction, is often present in early Parkinson's Disease (PD). However, the knowledge of the longitudinal progression of these symptoms, and the connection between
Charlotte B. Stewart +9 more
doaj +1 more source
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Nature Reviews Endocrinology, 2022 Organismal ageing is accompanied by progressive loss of cellular function and systemic deterioration of multiple tissues, leading to impaired function and increased vulnerability to death.
João A. Amorim +5 more
semanticscholar +1 more source
Telomere dysfunction in ageing and age-related diseases
Nature Cell Biology, 2022 Ageing organisms accumulate senescent cells that are thought to contribute to body dysfunction. Telomere shortening and damage are recognized causes of cellular senescence and ageing.
F. Rossiello +3 more
semanticscholar +1 more source
BMC Geriatrics, 2022 Background Our objective was to explore what people receiving and providing care consider to be ‘good’ in-home care for people living with dementia. Methods We conducted 36 in-depth interviews and two focus groups with key stakeholders in Australia in ...
Anita M. Y. Goh +20 more
doaj +1 more source
An aged immune system drives senescence and ageing of solid organs
Nature, 2021 Ageing of the immune system, or immunosenescence, contributes to the morbidity and mortality of the elderly1,2. To define the contribution of immune system ageing to organism ageing, here we selectively deleted Ercc1, which encodes a crucial DNA repair ...
Matthew J. Yousefzadeh +32 more
semanticscholar +1 more source
Inflammatory markers and incident frailty in men and women:the English Longitudinal Study of Ageing [PDF]
, 2013 Cross-sectional studies show that higher blood concentrations of inflammatory markers tend to be more common in frail older people, but longitudinal evidence that these inflammatory markers are risk factors for frailty is sparse and inconsistent.
Gale, Catharine R +7 more
core +1 more source
Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice
NatureBiological ageing can be defined as a gradual loss of homeostasis across various aspects of molecular and cellular function1,2. Mammalian brains consist of thousands of cell types3, which may be differentially susceptible or resilient to ageing.
Kelly Jin +38 more
semanticscholar +1 more source