Results 31 to 40 of about 723,040 (308)
A voxel-based morphometric study of ageing in 465 normal adult human brains
5th IEEE EMBS International Summer School on Biomedical Imaging, 2002., 2001 Voxel-based-morphometry (VBM) is a whole-brain, unbiased technique for characterizing regional cerebral volume and tissue concentration differences in structural magnetic resonance images.
C. Good +5 more
semanticscholar +1 more source
Ageing threatens sustainability of smallholder farming in China
Nature, 2023 Rapid demographic ageing substantially affects socioeconomic development^ 1 – 4 and presents considerable challenges for food security and agricultural sustainability^ 5 – 8 , which have so far not been well understood. Here, by using data from more than
Chen-Chen Ren +9 more
semanticscholar +1 more source
Feedback between p21 and reactive oxygen production is necessary for cell senescence
Molecular Systems Biology, 2010 Cellular senescence—the permanent arrest of cycling in normally proliferating cells such as fibroblasts—contributes both to age‐related loss of mammalian tissue homeostasis and acts as a tumour suppressor mechanism.
João F Passos +13 more
doaj +1 more source
Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity
Acta Neuropathologica Communications, 2023 G4C2 hexanucleotide repeat expansions in a non-coding region of the C9orf72 gene are the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Javier Morón-Oset +9 more
doaj +1 more source
Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Nature Reviews Cardiology, 2018 Most older individuals develop inflammageing, a condition characterized by elevated levels of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability, frailty, and premature death.
L. Ferrucci, E. Fabbri
semanticscholar +1 more source
The World Health Organization (WHO) approach to healthy ageing
Maturitas, 2020 The ageing of the global population is the most important medical and social demographic problem worldwide. The World Health Organization (WHO) has defined healthy ageing as a process of maintaining functional ability to enable wellbeing in older age ...
E. Rudnicka +5 more
semanticscholar +1 more source
mTOR: from growth signal integration to cancer, diabetes and ageing
Nature reviews. Molecular cell biology, 2010 In all eukaryotes, the target of rapamycin (TOR) signalling pathway couples energy and nutrient abundance to the execution of cell growth and division, owing to the ability of TOR protein kinase to simultaneously sense energy, nutrients and stress and ...
R. Zoncu, A. Efeyan, D. Sabatini
semanticscholar +1 more source
Dynamic lipidome alterations associated with human health, disease and ageing
Nature Metabolism, 2023 Lipids can be of endogenous or exogenous origin and affect diverse biological functions, including cell membrane maintenance, energy management and cellular signalling.
Daniel Hornburg +16 more
semanticscholar +1 more source
A multidimensional systems biology analysis of cellular senescence in aging and disease
Genome Biology, 2020 Background Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of aging and has been linked to aging-related diseases.
Roberto A. Avelar +15 more
doaj +1 more source
BMC Public Health, 2022 Background Physical activity is important to maintain health in older age, with physical activity in the outdoors providing mental and physical health benefits for all age groups.
Pazit Levinger +7 more
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