Results 31 to 40 of about 500,182 (302)
Balancing the struggle to live with dementia: a systematic meta-synthesis of coping
BMC Geriatrics, 2019 Background People with dementia describe experiences of loss that threaten their autonomy and ability to contribute to society. They often have difficulties with orientation, loss of roll function, and fear about the future, and need help from others. An
Guro Hanevold Bjørkløf +5 more
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Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity
Acta Neuropathologica Communications, 2023 G4C2 hexanucleotide repeat expansions in a non-coding region of the C9orf72 gene are the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Javier Morón-Oset +9 more
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The future of Age and Ageing [PDF]
Age and Ageing, 2002 The delivery of healthcare in the United Kingdom is going through a period of change, with many new developments. Some of these represent the aspirations of politicians and those who manage the National Health Service, and others are being forced upon us because of the shortage of resources (not always financial).
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Feedback between p21 and reactive oxygen production is necessary for cell senescence
Molecular Systems Biology, 2010 Cellular senescence—the permanent arrest of cycling in normally proliferating cells such as fibroblasts—contributes both to age‐related loss of mammalian tissue homeostasis and acts as a tumour suppressor mechanism.
João F Passos +13 more
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A multidimensional systems biology analysis of cellular senescence in aging and disease
Genome Biology, 2020 Background Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of aging and has been linked to aging-related diseases.
Roberto A. Avelar +15 more
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BMC Public Health, 2022 Background Physical activity is important to maintain health in older age, with physical activity in the outdoors providing mental and physical health benefits for all age groups.
Pazit Levinger +7 more
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Cells, 2021 Metastasis Associated Lung Adenocarcinoma Transcript-1 (MALAT1) is implicated in regulating the inflammatory response and in the pathology of several chronic inflammatory diseases, including osteoarthritis (OA).
Fawzeyah A. Alnajjar +7 more
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Inflammatory markers and incident frailty in men and women:the English Longitudinal Study of Ageing [PDF]
, 2013 Cross-sectional studies show that higher blood concentrations of inflammatory markers tend to be more common in frail older people, but longitudinal evidence that these inflammatory markers are risk factors for frailty is sparse and inconsistent.
Gale, Catharine R +8 more
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Age and Ageing: An Overview [PDF]
Occupational Medicine, 2000 Europe is ageing, as exemplified by the UK population where, in the foreseeable future, more people will be over than under age 50: industry appears slow to recognise and appreciate all that older workers still have to offer: bundling them off into early retirement wastes precious talents. Memory difficulty is not an inevitable part of ageing.
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The longitudinal progression of autonomic dysfunction in Parkinson's disease: A 7-year study
Frontiers in Neurology, 2023 BackgroundAutonomic dysfunction, including gastrointestinal, cardiovascular, and urinary dysfunction, is often present in early Parkinson's Disease (PD). However, the knowledge of the longitudinal progression of these symptoms, and the connection between
Charlotte B. Stewart +9 more
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