Results 21 to 30 of about 403,137 (309)

A multidimensional systems biology analysis of cellular senescence in aging and disease

Genome Biology, 2020
Background Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of aging and has been linked to aging-related diseases.
Roberto A. Avelar, Javier Gómez Ortega, Robi Tacutu, Eleanor J. Tyler, Dominic Bennett, Paolo Binetti, Arie Budovsky, Kasit Chatsirisupachai, Emily Johnson, Alex Murray, Samuel Shields, Daniela Tejada-Martinez, Daniel Thornton, Vadim E. Fraifeld, Cleo L. Bishop, João Pedro de Magalhães   +15 more
doaj   +1 more source

The ENJOY MAP for HEALTH: Exercise interveNtion outdoor proJect in the cOmmunitY for older people—More Active People for HEALTHier communities: a study protocol

BMC Public Health, 2022
Background Physical activity is important to maintain health in older age, with physical activity in the outdoors providing mental and physical health benefits for all age groups.
Pazit Levinger, Jeremy Dunn, Emma Abfalter, Briony Dow, Frances Batchelor, Stephanie Garratt, Neil T Diamond, Keith D. Hill   +7 more
doaj   +1 more source

The future of Age and Ageing [PDF]

Age and Ageing, 2002
The delivery of healthcare in the United Kingdom is going through a period of change, with many new developments. Some of these represent the aspirations of politicians and those who manage the National Health Service, and others are being forced upon us because of the shortage of resources (not always financial).
openaire   +2 more sources

The Expression and Function of Metastases Associated Lung Adenocarcinoma Transcript-1 Long Non-Coding RNA in Subchondral Bone and Osteoblasts from Patients with Osteoarthritis

Cells, 2021
Metastasis Associated Lung Adenocarcinoma Transcript-1 (MALAT1) is implicated in regulating the inflammatory response and in the pathology of several chronic inflammatory diseases, including osteoarthritis (OA).
Fawzeyah A. Alnajjar, Archana Sharma-Oates, Susanne N. Wijesinghe, Hussein Farah, Dominika E. Nanus, Tom Nicholson, Edward T. Davis, Simon W. Jones   +7 more
doaj   +1 more source

The longitudinal progression of autonomic dysfunction in Parkinson's disease: A 7-year study

Frontiers in Neurology, 2023
BackgroundAutonomic dysfunction, including gastrointestinal, cardiovascular, and urinary dysfunction, is often present in early Parkinson's Disease (PD). However, the knowledge of the longitudinal progression of these symptoms, and the connection between
Charlotte B. Stewart, David Ledingham, Victoria K. Foster, Kirstie N. Anderson, Sahana Sathyanarayana, Debra Galley, Nicola Pavese, Nicola Pavese, Jacopo Pasquini, Jacopo Pasquini   +9 more
doaj   +1 more source

Inflammatory markers and incident frailty in men and women:the English Longitudinal Study of Ageing [PDF]

, 2013
Cross-sectional studies show that higher blood concentrations of inflammatory markers tend to be more common in frail older people, but longitudinal evidence that these inflammatory markers are risk factors for frailty is sparse and inconsistent.
Gale, Catharine R, Cooper, Cyrus, Baylis, D, Sayer, AA, Cooper, C, Gale, CR, Sayer, Avan Aihie, Baylis, Daniel, Gale, Catharine R.   +8 more
core   +1 more source

HEARTS, minds and souls—it is time for geriatricians to bring more to continence management

, 2021
Urinary incontinence (UI), the involuntary loss of urine, is a common health condition that may decrease the quality of life and which increases in incidence and prevalence with age. Recent epidemiologic data suggest an overall prevalence of 38% in women
Gordon, A, Schlögl, Mathias, Schlögl, M, Gordon, Adam   +3 more
core   +1 more source

What constitutes ‘good’ home care for people with dementia? An investigation of the views of home care service recipients and providers

BMC Geriatrics, 2022
Background Our objective was to explore what people receiving and providing care consider to be ‘good’ in-home care for people living with dementia. Methods We conducted 36 in-depth interviews and two focus groups with key stakeholders in Australia in ...
Anita M. Y. Goh, Meg Polacsek, Sue Malta, Colleen Doyle, Brendan Hallam, Luke Gahan, Lee Fay Low, Claudia Cooper, Gill Livingston, Anita Panayiotou, Samantha M. Loi, Maho Omori, Steven Savvas, Jason Burton, David Ames, Samuel C. Scherer, Nadia Chau, Stefanie Roberts, Margaret Winbolt, Frances Batchelor, Briony Dow   +20 more
doaj   +1 more source

The association between life course socioeconomic position and life satisfaction in different welfare states:European comparative study of individuals in early old age [PDF]

, 2014
BACKGROUND: whether socioeconomic position over the life course influences the wellbeing of older people similarly in different societies is not known.OBJECTIVE: to investigate the magnitude of socioeconomic inequalities in life satisfaction among ...
Pell, Jill P., Katikireddi, Srinivasavittal, Katikireddi, Srinivasa Vittal, Katikireddi, Srinivasa, Mitchell, Richard, Niedzwiedz, Claire L, Pell, Jill P, Niedzwiedz, Claire L.   +7 more
core   +1 more source

Acceptability of the routine use and collection of a generic patient reported outcome measure from the perspective of healthcare staff: a qualitative study

Journal of Patient-Reported Outcomes, 2023
Background Patient-reported outcome measures (PROMs) provide a measure of self-perceived health status or health-related quality of life. They have been used to support provider-patient decisions, healthcare delivery, and value-based healthcare models. A
David A Snowdon, Velandai Srikanth, Richard Beare, Kate E Noeske, Elizabeth Le, Bridget O’Bree, Nadine E Andrew   +6 more
doaj   +1 more source