Results 91 to 100 of about 38,974 (312)

How ageing is shaped by trade-offs [PDF]

The evolution of different life history strategies and thus different ageing patterns essentially depends on the nature of the underlying trade-offs between survival and reproduction.
Annette Baudisch
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CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The Transformative Potential of Artful Ageing

Journal of Ageing and Longevity
This article explores the transformative potential of Artful Ageing as a conceptual framework for enriching experiences in later life. By synthesising Manning’s theory of minor gestures with Basting’s creative care approach, the article demonstrates how ...
Tine Fristrup
doaj   +1 more source

The synthetic theory of aging.

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 1988
Attempting to explain aging by a single factor was the weakness of most theories. G.A. Sacher proposed a synthetic theory named the longevity-assurance theory. Here, I propose a revised version of it. A comprehensive phylogenic tree based on molecular biology is available for organisms including bacteria, plants, protozoa, fungi, insects and ...
openaire   +3 more sources

AN IGNORED THEORY OF THE ICE AGE [PDF]

Science, 1906
n ...
openaire   +3 more sources

Ageing as a price of cooperation and complexity: Self-organization of complex systems causes the ageing of constituent networks

, 2008
The analysis of network topology and dynamics is increasingly used for the description of the structure, function and evolution of complex systems.
Huba J. M. Kiss, Ágoston Mihalik, Bálint Őry, Csaba Sőti, Peter Csermely, Tibor Nánási, Zoltán Spiró   +6 more
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Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Direct Single-Cell Analysis of Human Polar Bodies and Cleavage-Stage Embryos Reveals No Evidence of the Telomere Theory of Reproductive Ageing in Relation to Aneuploidy Generation

Cells, 2019
Reproductive ageing in women, particularly after the age of 35, is associated with an exponential increase in the proportion of chromosomally abnormal oocytes produced.
Kara Turner, Colleen Lynch, Hannah Rouse, Vimal Vasu, Darren K. Griffin   +4 more
doaj   +1 more source

Reconstructing Social Policy and Ageing [PDF]

, 2015
This article draws from the work of Michel Foucault to reconstruct an understanding of social policy and ageing in contemporary Britain. In many ways, policy provides three trajectories for older people; first, as independent self-managing consumers ...
Powell, Jason L., Powell, Jason, Halsall, Jamie   +2 more
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