Results 81 to 90 of about 38,974 (312)

The Economics of Population Ageing [PDF]

Demographic forecasts predict that over the next fifty years the proportion of people in New Zealand over the age of 65 will more than double, from 12 percent in 1999 to 26 percent in 2050.
Grant Scobie, John Stephenson
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A qualitative study protocol of ageing carers’ caregiving experiences and their planning for continuation of care for their immediate family members with intellectual disability

BMC Geriatrics, 2017
Background Understanding the difficulties and needs of the family carers in taking care of a person with ID can facilitate the development of appropriate intervention programmes and services to strengthen their caring capacity and empower them to ...
Lisa Pau Le Low, Wai Tong Chien, Lai Wah Lam, Kayla Ka Yin Wong   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Estimation of Remaining Insulation Lifetime of Aged XLPE Cables with Step-Stress Method Based on Physical-Driven Model

Energies
The remaining lifetime of the cable insulation is an important but hard topic for the industry and research groups as there are more and more cables nearing their designed life in China. However, it is hard to accurately and efficiently obtain the ageing
Yingqiang Shang, Jingjiang Qu, Jingshuang Wang, Jiren Chen, Jingyue Ma, Jun Xiong, Yue Li, Zepeng Lv   +7 more
doaj   +1 more source

Embodying 'active' ageing: bodies, emotions and risk in later life [PDF]

The promotion of 'active' ageing in later life has been a key development in recent health policy. These changes not only challenge the prevalent view of old age as an inevitable process of biological decline but signify the tendency of lay and expert ...
Martin, Wendy
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Park Planning for Ageing Adults Using Grounded Theory Methodology

Landscape Review, 2004
The importance of understanding park planning issues and implementing planning strategies for ageing adults was the driving force for this study. Literature reviews have identified a variety of scholarly work from fields such as gerontology, psychology ...
Bernie Dahl, Ken Jacobs
doaj  

Multiphysics Measurement Method for Supercapacitors State of Health Determination

Micromachines
This work presents a comparative study on the ageing of supercapacitors and a method for monitoring their state of health (SoH) through mechanical deformation.
Thomas Doucet, Jean-François Mogniotte, Raphaël Amiot, Alaa Hijazi, Pascal Venet, Minh-Quyen Le, Pierre-Jean Cottinet   +6 more
doaj   +1 more source