Results 91 to 100 of about 14,614 (302)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Ageism in the workplace - a case study

, 2012
A Liverpool John Moores University podcast where Sylvia French discusses a workplace case study in ...
Liverpool John Moores University, Sylivia French   +1 more
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Ageism in Medication Use in Older Patients

, 2018
Published studies have documented increased rates of adverse drug events, hospitalizations, mortality, and higher healthcare costs associated with inappropriate medication use among the population of older adults, in addition to various clinical, psycho ...
Daniela Fialová, Ingrid Kummer, Margita Držaić, Fialová, Daniela, Kummer, Ingrid, Marcel Leppee, Leppee, Marcel, Držaić, Margita   +7 more
core   +1 more source

The influence of patient's age on clinical decision-making about coronary heart disease in the USA and the UK [PDF]

, 2006
This paper examines UK and US primary care doctors' decision-making about older (aged 75 years) and midlife (aged 55 years) patients presenting with coronary heart disease (CHD).
Arber, S, Link, C, Link, Carol, Adams, Ann, Arber, Sara, Buckingham, Christopher D., Marceau, Lisa, McKinlay, JB, Buckingham, CD, Marceau, L, McKinlay, John, Adams, A   +11 more
core   +1 more source

Carta of Florence Against Ageism: No Place for Ageism in Healthcare

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences
No abstract ...
Ungar, Andrea, Cherubini, Antonio, Fratiglioni, Laura, de la Fuente-Núñez, Vânia, Fried, Linda, Krasovitsky, Marlane Sally, Tinetti, Mary, Officer, Alana, Vellas, Bruno, Ferrucci, Luigi   +9 more
openaire   +7 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Ageism and Associated Factors in Healthcare Workers: A Systematic Review

Nursing Reports
Background: Ageism refers to the presence of stereotypes, prejudices, and discrimination against older adults based on their age. In healthcare settings it negatively impacts opportunities for treatment, rehabilitation, and cure opportunities. This study
Laura Fernández-Puerta, Alexis Caballero-Bonafé, Juan Ramón de-Moya-Romero, Antonio Martínez-Sabater, Raquel Valera-Lloris   +4 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source