Results 101 to 110 of about 14,614 (302)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Wisdom's moderating role in the association between perceived ageism and life satisfaction among older adults in Japan: A pre-registered study

Archives of Gerontology and Geriatrics Plus
To maintain and improve older adults’ life satisfaction, identifying the associated variables is effective. Previous studies reported that older adults who strongly perceive ageism from their surroundings exhibit low life satisfaction.
Yuho Shimizu, Masashi Suzuki, Yukako Hata, Toshiro Sakaki   +3 more
doaj   +1 more source

Pandemic ageism [PDF]

Palliative and Supportive Care, 2021
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Ageism in the third age.

, 2018
In the developed world, later life has brought more opportunities to contribute to society and pursue personal goals outside the role of paid work, combined with less stigma and greater recognition of the worth of older people.
Sue Gardner, Angela Kydd, Kydd, Angela, Gardner, Sue, Hafford-Letchfield, Trish, Flemming, Anne, Hafford Letchfield, Trish, Trish Hafford-Letchfield, Fleming, Anne, Anne Fleming   +9 more
core   +1 more source

Educational Methods Using Intergenerational Interaction to Fight Ageism [PDF]

, 2018
Contemporary societies allow interactions between three or more generations at the same time. However, the emergence of multigenerational societies does not necessarily guarantee the eradication of ageism or age-related stereotypes.
Zwamborn, Marc, Marc Zwamborn, Metz, Susan, del Carmen Requena, Maria, van Hoof, Joost, Wilco P. H. Bosems, Requena, María del Carmen, Hannah J. Swift, Bosems, Wilco P. H., Joost van Hoof, Susan Metz, Swift, Hannah J., Laura Naegele, María del Carmen Requena, Naegele, Laura, Bosems, Wilco P.H, Hoof, Joost van   +16 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Sexuality and ageism

, 2018
This short talk was produced as part of the work of COST IS1402 on ageism from a multi-national interdisciplinary perspective (notoageism.com). COST is an EU-funded programme that enables researchers to set up their interdisciplinary research networks in
Hafford-Letchfield, T.
core  

Ageism and Attitudes Toward Older Adults in Arab Culture: A Systematic Integrative Review

Social Sciences
Ageism refers to prejudice on the basis of a person’s age, often directed toward older adults. Arab culture represents a pertinent case, as this culture is historically known for its appreciation of older people, but recent studies have indicated high ...
Rudy S. Younes, Mirna Abboud Mzawak
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source