Results 131 to 140 of about 41,447 (292)
Targeted LGBT Senior Housing: A Study of the Needs and Perceptions of LGBT Seniors in Chicago [PDF]
, 2005 Although lesbian gay bisexual and transgendered (LGBT) seniors face issues similar to their heterosexual counterparts such as declining health, dwindling finances, depression, social isolation, and ageism, they also face unique issues such as ...
Curtis Jones, Grace Gedar
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An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Self-perceived age categorization as a determinant of the old age boundary [PDF]
Using data from the European Social Survey, we investigate the influence of individuals' self-perceptions of being a member of an age group on their assessment of the beginning of ‘old age'.
Cem Baslevent
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Gerontology Theory Communicated in the Primary Grades through Picture Books [PDF]
, 2018 Educational Objectives 1. To recognize children’s first literature as a means of socialization to aging and older people. 2. To identify children’s books that reflect basic principles of gerontology theory. 3.
Ansello, Edward F.
core +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Research & PoliticsAgeing populations are reshaping the political landscape in many democracies, raising concerns about intergenerational inequalities in power and representation. Do these political factors contribute to ageism toward older people?
Alonso Román Amarales, Scott Williamson
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The Debate about Mandatory Retirement in Ontario Universities: Positive and Personal Choices about Retirement at 65 [PDF]
The debate about mandatory retirement is fundamentally a moral issue, about human rights, but one strongly related to several major economic issues. Mandatory retirement is a form of age discrimination that seems to be strictly prohibited by section 15(1)
John H. A. Munro
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