Results 91 to 100 of about 1,970,820 (299)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Determinants of director compensation in two-tier systems: evidence from German panel data [PDF]

open access: yes
Building on a unique panel data set of German Prime Standard companies for the period 2005-2008, this paper investigates the influencing factors of both director compensation levels and structure, i.e.
Andreas, Jörn Michael   +2 more
core  

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Common Agency and Computational Complexity: Theory and Experimental Evidence [PDF]

open access: yes
In a common agency game, several principals try to influence the behavior of an agent. Common agency games typically have multiple equilibria. One class of equilibria, called truthful, has been identified by Bernheim and Whinston and has found widespread
Kirchsteiger, G., Prat, A.
core   +1 more source

Bonding, Bridging, and Social Change [PDF]

open access: yes, 2009
This paper discusses the efficacy of using Robert Putnam’s theory of social capital as the framework for forming long-term reciprocal relationship amongst Writing students, faculty, clients and staff of a community-based agency.
Nester, Nancy L.
core   +1 more source

Critical Realism and Empirical Research Methods in Education [PDF]

open access: yes, 2005
In the light of recent writings of Richard Pring, and in relation to the application of empirical research methods in education, this paper offers a corrective to a neo-realist viewpoint and develops a critical realist perspective.
Scott, David
core   +3 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

The Role of Agency and Institutional Theory in the Planning and Realization for Capital Expenditures

open access: yesJurnal Dinamika Akuntansi, 2017
The capital expenditures are part of direct expenditure in the regional budget. The other elements of capital expenditures are: personnel expenditure, and spending on goods and services.
Syaiful Hifni
doaj   +1 more source

Quitting in Protest: A Theory of Presidential Policy Making and Agency Response [PDF]

open access: yes, 2015
This paper examines the effects of centralized presidential policy-making, implemented through unilateral executive action, on the willingness of bureaucrats to exert effort and stay in the government.
Cameron, Charles M.   +2 more
core   +1 more source

The Place of the Trace: Negligence and Responsibility [PDF]

open access: yes, 2020
One popular theory of moral responsibility locates responsible agency in exercises of control. These control-based theories often appeal to tracing to explain responsibility in cases where some agent is intuitively responsible for bringing about some ...
Murray, Samuel
core  

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