Results 91 to 100 of about 47,987 (262)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Assessing the impact of revising MenACWY vaccination schedule for adolescents in the United States: a modelling studyResearch in context

The Lancet Regional Health. Americas
Summary: Background: The current recommendation for MenACWY vaccination against invasive meningococcal disease (IMD) in the United States (US) includes two doses: the first dose at ages 11–12 and a booster dose at age 16.
Affan Shoukat, Chad R. Wells, Thomas Shin, Lilia Potter-Schwartz, Alison P. Galvani, Seyed M. Moghadas   +5 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

An Agent-based Model for the Humanities

Digital Humanities Quarterly, 2013
The Humanities now confront a new era in cultural representations — the digital age. As a consequence, our approach to culture may be modified because technology allows us to now visualize our thoughts and theories using digital and computing techniques.
openaire   +2 more sources

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Simulating Port Expansion Plans using Agent based Modelling

International Journal of Technology, 2015
 Jakarta International Container Terminal (JICT), which is the main international port of Indonesia, is overcrowded and is going to be expanded.
Ramadhianto Agung Wibowo, Akhmad Hidayatno, Komarudin, Armand Omar Moeis   +3 more
doaj   +1 more source

An agent-based model of citation behavior

Applied Network Science
Abstract Whether citations objectively and reliably reflect the quality of articles and researchers is questionable. Even so, citation counts are widely used to estimate the productivity of researchers and institutions, which creates a ‘grubby’ motivation to be well-cited.
George Chacko, Minhyuk Park, Vikram Ramavarapu, Ananth Grama, Pablo Robles-Granda, Tandy J. Warnow   +5 more
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

On the Limits of Agency in Agent-based Models

International Joint Conference on Autonomous Agents and Multiagent Systems
Agent-based modeling (ABM) offers powerful insights into complex systems, but its practical utility has been limited by computational constraints and simplistic agent behaviors, especially when simulating large populations. Recent advancements in large language models (LLMs) could enhance ABMs with adaptive agents, but their integration into large ...
Ayush Chopra, Shashank Kumar, Nurullah Giray Kuru, Ramesh Raskar, Arnau Quera-Bofarull   +4 more
openaire   +3 more sources