Results 81 to 90 of about 459,186 (346)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Integrating artificial intelligence with mechanistic epidemiological modeling: a scoping review of opportunities and challenges

Nature Communications
Integrating prior epidemiological knowledge embedded within mechanistic models with the data-mining capabilities of artificial intelligence (AI) offers transformative potential for epidemiological modeling.
Yang Ye, Abhishek Pandey, Carolyn Bawden, Dewan Md. Sumsuzzman, Rimpi Rajput, Affan Shoukat, Burton H. Singer, Seyed M. Moghadas, Alison P. Galvani   +8 more
doaj   +1 more source

Creating a Modeling Language Based on a New Metamodel for Adaptive Normative Software Agents [PDF]

, 2022
Marx Viana, Paulo Alencar, Everton Guimarães, Elder Cirilo, Carlos Lucena   +4 more
openalex   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Using Hybrid Agent-Based Systems to Model Spatially-Influenced Retail Markets [PDF]

One emerging area of agent-based modelling is retail markets; however, there are problems with modelling such systems. The vast size of such markets makes individual-level modelling, for example of customers, difficult and this is particularly true where
Alison Heppenstall, Andrew Evans, Mark Birkin   +2 more
core  

Methods and Tools for the Microsimulation and Forecasting of Household Expenditure [PDF]

, 2008
This paper reviews potential methods and tools for the microsimulation and forecasting of household expenditure. It begins with a discussion of a range of approaches to the forecasting of household populations via agent-based modelling tools.
Lawson, Tony
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Agent-based modelling. History, essence, future

PSL Quarterly Review, 2017
The paper characterizes the currently fashionable modelling tool, agent-based simulation. First, it presents a selection of the major intellectual roots from which this new tool emerged. It is important for social scientists, in particular economists, to
Gerhard Hanappi
doaj   +3 more sources

The synergy of therapeutic vaccination and timely diagnosis for TB control in high-burden settings: Nunavut as a case study

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
Background: Although the overall prevalence of Tuberculosis (TB) in Canada is relatively low, Indigenous communities are disproportionately burdened, with active TB rates exceeding those of Canadian-born non-Indigenous populations by more than 55-fold ...
Elaheh Abdollahi, Seyed M. Moghadas, Alison P. Galvani   +2 more
doaj   +1 more source