Results 41 to 50 of about 459,186 (346)

Variance in System Dynamics and Agent Based Modelling Using the SIR Model of Infectious Disease [PDF]

, 2012
Classical deterministic simulations of epidemiological processes, such as those based on System Dynamics, produce a single result based on a fixed set of input parameters with no variance between simulations. Input parameters are subsequently modified on
Ahmed, Aslam, Aickelin, Uwe, Greensmith, Julie   +2 more
core   +4 more sources

Institutional modelling: Adding social backbone to agent-based models

MethodsX, 2022
Institutional modelling is a branch of agent-based modelling and simulation (ABMS) that pays special attention to the social structure by incorporating institutions into these models.
Amineh Ghorbani
doaj   +1 more source

Deviation from the recommended schedule: optimal dosing interval for a two-dose vaccination programme

Royal Society Open Science
Optimizing vaccination impact during an emerging disease becomes crucial when vaccine supply is limited, and robust protection requires multiple doses.
Zhen Wang, Gergely Röst, Seyed M. Moghadas   +2 more
doaj   +1 more source

Optimal COVID-19 quarantine and testing strategies

Nature Communications, 2021
Safely reducing the necessary duration of quarantine for COVID-19 could lessen the economic impacts of the pandemic. Here, the authors demonstrate that testing on exit from quarantine is more effective than testing on entry, and can enable quarantine to ...
Chad R. Wells, Jeffrey P. Townsend, Abhishek Pandey, Seyed M. Moghadas, Gary Krieger, Burton Singer, Robert H. McDonald, Meagan C. Fitzpatrick, Alison P. Galvani   +8 more
doaj   +1 more source

Key challenges in agent-based modelling for geo-spatial simulation [PDF]

, 2007
Agent-based modelling (ABM) is fast becoming the dominant paradigm in social simulation due primarily to a worldview that suggests that complex systems emerge from the bottom-up, are highly decentralised, and are composed of a multitude of heterogeneous ...
Batty, M, Castle, C, Crooks, A
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Comparative analyses of eighteen rapid antigen tests and RT-PCR for COVID-19 quarantine and surveillance-based isolation

Communications Medicine, 2022
Wells et al. use mathematical modeling to compare quarantine duration, testing frequency, and false-positive rate for 18 rapid antigen (RA) and RT-PCR tests.
Chad R. Wells, Abhishek Pandey, Seyed M. Moghadas, Burton H. Singer, Gary Krieger, Richard J. L. Heron, David E. Turner, Justin P. Abshire, Kimberly M. Phillips, A. Michael Donoghue, Alison P. Galvani, Jeffrey P. Townsend   +11 more
doaj   +1 more source

An improved multi-agent simulation methodology for modelling and evaluating wireless communication systems resource allocation algorithms [PDF]

, 2008
Multi-Agent Systems (MAS) constitute a well known approach in modelling dynamical real world systems. Recently, this technology has been applied to Wireless Communication Systems (WCS), where efficient resource allocation is a primary goal, for modelling
Karras, D., Papademetriou, Rallis, Papazoglou, P.   +2 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source