Results 51 to 60 of about 431,918 (275)

Fractional modeling of COVID-19 dynamics

CQD Revista Eletrônica Paulista de Matemática, 2022
The present work seeks to provide a comparison between the classical epidemiological model using ordinary differential equations and an approach through the fractional calculus, using the COVID-19 pandemic in Brazil as a case study.
Micaeli Mendola Theodoro, Thomas Nogueira Vilches, Rubens de Figueiredo Camargo, Paulo Fernando de Arruda Mancera   +3 more
doaj  

Rule-based Modelling and Tunable Resolution [PDF]

, 2009
We investigate the use of an extension of rule-based modelling for cellular signalling to create a structured space of model variants. This enables the incremental development of rule sets that start from simple mechanisms and which, by a gradual ...
Russ Harmer, S. Barry Cooper, Vincent Danos   +2 more
core   +5 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Impact of disease severity, age, sex, comorbidity, and vaccination on secondary attack rates of SARS-CoV-2: a global systematic review and meta-analysis

BMC Infectious Diseases
Background Understanding the key drivers of SARS-CoV-2 transmission is essential for shaping effective public health strategies. However, transmission risk is subject to substantial heterogeneity related to disease severity, age, sex, comorbidities, and ...
Dewan Md. Sumsuzzman, Yang Ye, Zhen Wang, Abhishek Pandey, Joanne M. Langley, Alison P. Galvani, Seyed M. Moghadas   +6 more
doaj   +1 more source

Going Stupid with EcoLab [PDF]

, 2006
In 2005, Railsback et al. proposed a very simple model ({\em Stupid Model}) that could be implemented within a couple of hours, and later extended to demonstrate the use of common ABM platform functionality.
Standish, Russell K.
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

ABMU: An Agent-Based Modelling Framework for Unity3D

SoftwareX, 2021
The field of Agent-Based Modelling (ABM) has expanded significantly since its emergence, with a plethora of ABM development frameworks available to researchers today.
Kostas Cheliotis
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Impact of information dissemination and behavioural responses on epidemic dynamics: A multi-layer network analysis

Infectious Disease Modelling
Network models adeptly capture heterogeneities in individual interactions, making them well-suited for describing a wide range of real-world and virtual connections, including information diffusion, behavioural tendencies, and disease dynamic ...
Congjie Shi, Silvio C. Ferreira, Hugo P. Maia, Seyed M. Moghadas   +3 more
doaj   +1 more source

A practical generation-interval-based approach to inferring the strength of epidemics from their speed

Epidemics, 2019
Infectious disease outbreaks are often characterized by the reproduction number R and exponential rate of growth r. R provides information about outbreak control and predicted final size, but estimating R is difficult, while r can often be estimated ...
Sang Woo Park, David Champredon, Joshua S. Weitz, Jonathan Dushoff   +3 more
doaj   +1 more source