Results 91 to 100 of about 4,273 (188)
Recombinant LPG3 Protein From Leishmania chagasi as an Antigen for the Diagnosis of Canine Visceral Leishmaniasis
Tropical Medicine &International Health, EarlyView.ABSTRACT
Visceral leishmaniasis (VL) is a human neglected tropical disease in which dogs participate as reservoirs of the etiological agent Leishmania chagasi. The identification of infected dogs is important to the control of VL, and recombinant proteins are strong antigen candidates for canine visceral leishmaniasis (CVL) serodiagnosis. In this work, Thaís Viana Fialho Martins, Anna Cláudia Alves de Souza, Bianca Meireles Miranda, Ronny Francisco de Souza, Daniel Silva Sena Bastos, Neverton José Silva Ferreira, Tiago Antônio de Oliveira Mendes, Celeste da Silva Freitas de Souza, George Luiz Lins Machado‐Coelho, Maria Terezinha Bahia, Leandro Licursi de Oliveira, Juliana Lopes Rangel Fietto, Eduardo de Almeida Marques‐da‐Silva +12 morewiley +1 more sourceEnvironmental Distribution of Pathogenic Leptospira spp. in Subtropical Rivers of Japan and Implications for Human Infection
Tropical Medicine &International Health, EarlyView.ABSTRACT Objectives
Leptospirosis is a zoonotic disease caused by Leptospira spp. often linked to freshwater exposure in subtropical and tropical regions. Okinawa Prefecture reports the highest number of leptospirosis cases in Japan based on national surveillance data.Atsuhiro Kanayama, Hiroko Ejiri, Yuki Chiko, Ikumi Namihira, Tomoki Yonaha, Kanetaka Kuba, Miyu Yoshimi, Nobuo Koizumi, Shigeto Takeshima, Koki Kaku +9 morewiley +1 more sourceFucosylation limits ADCC in clinically used anti‐RhD monoclonal antibodies
Transfusion, EarlyView.Abstract Background
Haemolytic disease of the fetus and newborn (HDFN) is caused by maternal alloantibodies, often targeting the D antigen on fetal red blood cells. Maternal immunization is preventable with timely administration of anti‐D polyclonal antibodies (pAbs).Gabriela Koike, Albert Bondt, Douwe Schulte, Rien Leuvenink, Dirk Jan Mons, Peter C. Ligthart, E. Joanne T. Verweij, AFRICARhE Consortium, Enrico Lopriore, E. J. T. Joanne Verweij, Tienke Vermeiden, Thomas van den Akker, C. Ellen van der Schoot, Derek P. de Winter, Renske van Oever, Abera Kenay Tura, Tadesse Gure, Assefa Desalew, Tewodros Tesfa, Konjit Eshetu, Jeremia Pyuza, Rafiki N. Mjema, Priscus John Mapendo, Jeremiah John Hhera, Bariki Mchome, Patricia Swai, Blandina T. Mmbaga, Aisa Shayo, Peter Moons, Kondwani Kawaza, Luis Gadama, Albert J. R. Heck, C. Ellen van der Schoot, Gestur Vidarsson +33 morewiley +1 more sourceEstablishment and optimization of an E. coli urinary tract infection model in Göttingen minipigs with strain recovery and characterization
Frontiers in ImmunologyIntroductionUrinary tract infections caused by uropathogenic E. coli (UPEC) affect millions of individuals worldwide. Existing animal models used to study UTI treatment or vaccine efficacy have limitations and cannot accurately predict efficacy in humans.Joyce Lübbers, Kaila Orlandini, Emily Podob, Jeffrey Fernandez, Jolaine M Wilson, Marjolein van Heerden, Jeroen Zeijpveld, Joan van Kregten, Peter T. Buckley, Germie van den Dobbelsteen, Kirsten L. Bair +10 moredoaj +1 more sourceRare antigen‐negative red blood cells from pluripotent stem cells for precision transfusion medicine
Transfusion, EarlyView.Abstract Background
Blood bank identification of antibodies against high‐prevalence antigens remains a challenge due to the scarcity of antigen‐negative reagent red cells sourced from blood donors. The MAM antigen, encoded by EMP3, is one such antigen associated with red cell alloimmunization and hemolytic disease of the fetus and newborn. Study Design Naomi Gunawardena, Hyun Hyung An, Randall W. Veliquette, Edmund Carvalho, Sambit Dalui, Kaoru Takasaki, Eric Wafula, Deborah L. French, Giulia Pavani, Stella T. Chou +9 morewiley +1 more sourceInternational multicentre evaluation of a new anti‐idiotypic anti‐daratumumab for resolving pre‐transfusion interferences
Vox Sanguinis, EarlyView.Abstract Background and Objectives
Daratumumab, a therapeutic human anti‐CD38 monoclonal antibody, improves multiple myeloma outcomes but interferes with pre‐transfusion testing by binding CD38 on reagent red blood cells (RBCs), potentially masking clinically significant alloantibodies.Arnaud Reggiani, Sofia Lejon Crottet, Sophie Waldvogel, Charlotte Engström, Serelina Coluzzi, Antonella Matteocci, Janis R. Hamilton, Levent Tufan Kumas, Karen M. K. de Vooght, Jill R. Storry, Jennylyn Flores, Núria Nogués, Carlos Cotorruelo, Molly Rutherford, Eveline B. Nilsen, Monika Pelc‐Kłopotowska, Jolanta Korzeniowska, Alessandra Baffa, Inna Sareneva, Nor Hafizah Ahmad, Katarzyna Szczudlo, Athif Rahman, Laser Sanal, Lise Jørgensen, Karolina Majewska Rochowiak, Monika Salwierz, Elisaveta Grancharova, Bojana Zivkovic, Jessica Alvarez, Mareike Riedl, Achim Knappik +30 morewiley +1 more sourceMolecular characterization of D variants in Brazilian blood donors and their association with RhCE and Duffy phenotypes
Vox Sanguinis, EarlyView.Abstract Background and Objectives
Serological classification of RhD‐negative and weak D is often insufficient in admixed populations, where diverse RHD variants have clinical implications. In Brazil's highly admixed population, RhD interpretation and donor–recipient matching are particularly challenging.Thamy C. S. Silva, Marcia R. Dezan, Sidneia Costa, Beatriz C. Girardo, Bruno R. Cruz, Karen Ziza, Dante M. Langhi, José O. Bordin, Lilian Castilho, Carla L. Dinardo +9 morewiley +1 more sourceSafety and Effectiveness of Sutimlimab in Cold Agglutinin Disease: A Real‐World International Experience
American Journal of Hematology, Volume 101, Issue 7, Page 1597-1604, July 2026.ABSTRACT
Sutimlimab is a monoclonal antibody against complement fraction C1s approved for the treatment of hemolytic anemia due to cold agglutinin disease (CAD). Here, we analyzed and report the largest international CAD cohort of sutimlimab‐treated patients ever reported to highlight its safety and effectiveness in the real‐world setting. We accrued a Bruno Fattizzo, Elisa Sambruna, Yoshitaka Miyakawa, Marc Michel, Carlo Visco, Michael Fillitz, George Kannourakis, Maria Bruna Greve, Moritz Kleemiss, Johan Cid, Andrea Patriarca, Laura Pavan, Arbana Dizdari, Nilla Maschio, Antonella Sau, Cinzia Bitetti, Riccardo Mario Colombo, Luigi Curreli, Dorela Lame, Uros Markovic, Fabrizio Pappagallo, Giacinto Luca Pedone, Davide Rapezzi, Vincenzo Sammartano, Nicola Tumedei, Antonio Giovanni Solimando, Jalink Marit, Luana Fianchi, Jahanzaib Khwaja, Antonio De Vivo, Francesco Lanza, Fabrizio Vianello, Esther N. Oliva, Catherine Broome, Francesco Passamonti, Ulrich Jaeger, Bernd Jilma, Guillaume Moulis, Wilma Barcellini +38 morewiley +1 more source