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Aggrecan: Beyond cartilage and into the brain
The International Journal of Biochemistry & Cell Biology, 2012Aggrecan is well-studied in cartilage but its expression and function in the central nervous system has only recently begun to be appreciated. Aggrecan plays an important role in the organization of the neural extracellular space by binding and organizing hyaluronan to the cell surface through interactions with link protein and tenascins forming a ...
Morawski, M. +3 more
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Aggrecan degradation in osteoarthritis and rheumatoid arthritis
Acta Orthopaedica Scandinavica, 1995Aggrecan turnover is critically important to maintain extracellular matrix homeostasis in articular cartilage. Cartilage aggrecan metabolism has been studied in chondrocyte cell cultures, cartilage explant cultures, and in whole animal models. In many of these studies, matrix metalloproteinases (MMPs) are proposed to degrade cartilage aggrecan.
M W, Lark, E K, Bayne, L S, Lohmander
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2002
Hyaluronan (HA) is a high molecular weight (105-107Da) unbranched glycosaminoglycan, composed of repeating disaccharides of D-N-Acetylglucosamine and D-Glucuronic acid. It is a widely distributed component of the extracellular matrix of vertebrate tissues [1].
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Hyaluronan (HA) is a high molecular weight (105-107Da) unbranched glycosaminoglycan, composed of repeating disaccharides of D-N-Acetylglucosamine and D-Glucuronic acid. It is a widely distributed component of the extracellular matrix of vertebrate tissues [1].
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Synthesis and characterization of an aggrecan mimic
Acta Biomaterialia, 2012Aggrecan (AGG) is a large, aggregating proteoglycan present throughout the body, but predominantly found in articular cartilage. The principle features of AGG, its hyaluronan (HA) binding domain and its abundance of covalently attached glycosaminoglycans (GAGs), make it an essential component of the functional ability of articular cartilage.
Jonathan C, Bernhard, Alyssa, Panitch
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Changes in aggrecan populations in experimental osteoarthritis
Osteoarthritis and Cartilage, 1994Adult articular cartilage contains at least two distinct populations of aggrecan: one is larger and richer in chondroitin sulfate (CS), while the other is smaller with less CS. The smaller form is thought to be derived from the larger. The amount of CS in cartilage decreases with maturation and aging, mainly because of a decrease in the proportion of ...
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Glucose enhances aggrecan expression in chondrocytes via the PKCα/p38‐miR141‐3p signaling pathway
Journal of Cellular Physiology, 2018Tsung-Ju Wu +4 more
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