Results 231 to 240 of about 36,790 (258)

Quantitative analysis of the effects of hyaluronan and aggrecan concentration and hyaluronan size on the elasticity of hyaluronan–aggrecan solutions

Biorheology: The Official Journal of the International Society of Biorheology, 2004
We determined elasticity (G′) and viscosity (G″) of various aggrecan–hyaluronan solutions using a controlled‐stress rheometer with high (10 Hz) to low (0.1 Hz) frequencies. Aggrecan solution (50 mg/ml) alone showed little elasticity at any frequency, but the addition of 3300 kDa hyaluronan at 0.001–0.1 mg/ml markedly increased the elasticity, but not ...
M, Nishimura, M, Kawata, W, Yan, A, Okamato, H, Nishimura, Y, Ozaki, T, Hamada, Y, Kato   +7 more
openaire   +2 more sources

Sensitivity of monoclonal antibody, 5-D-4, for the detection of aggrecan, aggrecan fragments, and keratan sulfate

Agents and Actions, 1993
Bovine nasal septum aggrecan and selected proteinase-digested products of aggrecan were evaluated in an inhibition ELISA using the anti-keratan sulfate (KS) monoclonal antibody 5-D-4 (5D4). Undegraded aggrecan was recognized with an IC50 of 0.27 microgram/ml.
C A, Saphos, P, Dey, M W, Lark, V L, Moore   +3 more
openaire   +2 more sources

Analysis of Aggrecan Catabolism by Immunoblotting and Immunohistochemistry

2011
Aggrecan is essential for the normal function of articular cartilage and intervertebral disc, where it provides the ability for the tissues to withstand compressive loading. This property depends on both the high charge density endowed by its numerous chondroitin sulfate and keratan sulfate chains and its ability to form large molecular aggregates via ...
Peter J, Roughley, John S, Mort
openaire   +2 more sources

Aggrecan: Approaches to Study Biophysical and Biomechanical Properties

2014
Aggrecan, the most abundant extracellular proteoglycan in cartilage (~35 % by dry weight), plays a key role in the biophysical and biomechanical properties of cartilage. Here, we review several approaches based on atomic force microscopy (AFM) to probe the physical, mechanical, and structural properties of aggrecan at the molecular level.
Hadi Tavakoli, Nia, Christine, Ortiz, Alan, Grodzinsky   +2 more
openaire   +3 more sources

Aggrecan

2011
openaire   +2 more sources

Aggrecan

2006
openaire   +2 more sources

Aggrecan

2000
Barbara Vertel, Anthony Ratcliffe
openaire   +1 more source

Antibodies to MMP-Cleaved Aggrecan

2003
Fosang, AJ, Last, K, Jackson, DC, Brown, L   +3 more
openaire   +3 more sources

Load-Controlled Compression of Articular Cartilage Induces a Transient Stimulation of Aggrecan Gene Expression

Archives of Biochemistry and Biophysics, 1998
Wilmot B Valhmu, Van C Mow
exaly  

Degradation of cartilage aggrecan by collagenase-3 (MMP-13)

FEBS Letters, 1996
Amanda J Fosang, Karena Last, Vera Knauper   +2 more
exaly