Results 121 to 130 of about 2,012 (172)
Exploratory transcriptomic analysis of mouse articular cartilage in response to tissue inhibitor of metalloproteinase 3 identifies inflammation-associated gene expression changes. [PDF]
Front ImmunolMengozzi M +5 more
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Clinical and molecular landscape of post-traumatic osteoarthritis. [PDF]
Connect Tissue ResTakase K +3 more
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Licorice-derived prenylated chalcones alleviate knee osteoarthritis via multi-target modulation of PI3K-Akt, MAPK and HIF-1α signaling: an integrative UPLC-Q-TOF-MS/MS, network pharmacology and molecular dynamics study. [PDF]
Front BioinformQian W, Zeng J.
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Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2)
Biochemical and Biophysical Research Communications, 2016ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2), members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) gene family, are considered to play a key role in aggrecan degradation of articular cartilage in human osteoarthritis.
Yasunori Okada, Satsuki Mochizuki
exaly +3 more sources
A microplate assay specific for the enzyme aggrecanase
Analytical Biochemistry, 2003We have identified a 41-residue peptide, bracketing the aggrecanase cleavage site of aggrecan, that serves as a specific substrate for this enzyme family. Biotinylation of the peptide allowed its immobilization onto streptavidin-coated plates. Aggrecanase-mediated hydrolysis resulted in an immobilized product that reveals an N-terminal neoepitope ...
Michael A Pratta, Rui-Qin Liu
exaly +3 more sources
Biochimie, 2013
Members of the ADAMTS family of proteases degrade proteoglycans and thereby have the potential to alter tissue architecture and regulate cellular functions. Aggrecanases are the main enzymes responsible for aggrecan degradation, due to their specific cleavage pattern.
S, Filou +9 more
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Members of the ADAMTS family of proteases degrade proteoglycans and thereby have the potential to alter tissue architecture and regulate cellular functions. Aggrecanases are the main enzymes responsible for aggrecan degradation, due to their specific cleavage pattern.
S, Filou +9 more
openaire +2 more sources
An Aggrecanase and Osteoarthritis
New England Journal of Medicine, 2005The aggrecanases — enzymes that break down cartilage — are attractive candidates as drug targets. Studies of two mouse models implicate a single aggrecanase as a mediator of the erosion of cartilage in osteoarthritis.
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Current Pharmaceutical Biotechnology, 2008
Loss of aggrecan from articular cartilage is an early and critical event in the pathogenesis of osteoarthritis (OA) and is enzymatically mediated by aggrecanase activity. Since the discovery of aggrecanase-1 (ADAMTS-4) and aggrecanase-2 (ADAMTS-5), both members of the "a disintegrin and metalloproteinase with thrombospondin motif" family of proteinases,
M D, Tortorella, A M, Malfait
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Loss of aggrecan from articular cartilage is an early and critical event in the pathogenesis of osteoarthritis (OA) and is enzymatically mediated by aggrecanase activity. Since the discovery of aggrecanase-1 (ADAMTS-4) and aggrecanase-2 (ADAMTS-5), both members of the "a disintegrin and metalloproteinase with thrombospondin motif" family of proteinases,
M D, Tortorella, A M, Malfait
openaire +2 more sources
Aggrecanase-mediated cartilage degradation
Current Opinion in Pharmacology, 2002Increasing evidence is accumulating for the importance of the aggrecanases ADAMTS-4 and ADAMTS-5 in cartilage degradation in arthritis. Recent work from a number of laboratories has begun to provide insight into the regulation of the expression and activity of these proteins and the molecular basis of their role in aggrecan catabolism.
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Journal of Medicinal Chemistry, 2017
Aggrecanase-1 and -2 (ADAMTS-4 and ADAMTS-5) are zinc metalloproteases involved in the degradation of aggrecan in cartilage. Inhibitors could provide a means of altering the progression of osteoarthritis. We report the identification of 7 which had good oral pharmacokinetics in rats and showed efficacy in a rat chemical model of osteoarthritis.
Timothy B. Durham +10 more
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Aggrecanase-1 and -2 (ADAMTS-4 and ADAMTS-5) are zinc metalloproteases involved in the degradation of aggrecan in cartilage. Inhibitors could provide a means of altering the progression of osteoarthritis. We report the identification of 7 which had good oral pharmacokinetics in rats and showed efficacy in a rat chemical model of osteoarthritis.
Timothy B. Durham +10 more
openaire +2 more sources