Results 131 to 140 of about 2,012 (172)

Aggrecanases and Aggrecanase-generated Fragments in the Human Intervertebral Disc at Early and Advanced Stages of Disc Degeneration

Spine, 2007
A comparative study of aggrecanases and aggrecan fragmentation profile in the human intervertebral disc at early and advanced stages of disc degeneration.To determine differences in the content of the aggrecanases and the profile of aggrecan fragmentation in early and advanced stages of disc degeneration using cadaveric human intervertebral discs ...
Kalpa P, Patel, John D, Sandy, Koji, Akeda, Kei, Miyamoto, Takehide, Chujo, Howard S, An, Koichi, Masuda   +6 more
openaire   +2 more sources

Matrix Metalloproteinases And Aggrecanase

Spine, 2000
A comprehensive immunohistochemical study of matrix metalloproteinase activity in discs from patients with different disc diseases.To identify individual matrix metalloproteinase enzymes that could contribute to the degeneration of the matrix of the intervertebral disc, to identify the cells that produce matrix metalloproteinases (for example, the ...
S, Roberts, B, Caterson, J, Menage, E H, Evans, D C, Jaffray, S M, Eisenstein   +5 more
openaire   +2 more sources

[Aggrecanases and osteoarthritis].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2011
Osteoarthritis is mainly caused by the degenerative changes of cartilage and cartilage extracellular matrix, while Aggrecanases degradate Proteoglycans which are the major components of cartilage. This review includes three aspects: (1) We have concluded the major enzymes(ADAMTS-4 and ADAMTS-5) which regulate the metabolism of cartilage extracellular ...
Chao, Li, Yong Ping, Cao, Zhen Peng, Guan, De Yong, Huang, Zi Gang, Ge   +4 more
openaire   +1 more source

Advances in the development of novel aggrecanase inhibitors

Expert Opinion on Therapeutic Patents, 2010
Aggrecanases are members of a disintegrin and metalloprotease with thrombospondin motif family of zinc metalloproteases involved in the cleavage of aggrecan fragments in cartilage. Inhibition of aggrecanase activity in osteoarthritis (OA) patients should both provide symptomatic relief of OA pain as well as OA disease modification.This article reviews ...
Adam M, Gilbert, Jack A, Bikker, Steven V, O'Neil   +2 more
openaire   +2 more sources

Inhibition of Aggrecanases as a Therapeutic Strategy in Osteoarthritis

Future Medicinal Chemistry, 2014
Over the last decade, there has been a large effort to target aggrecanases, which are responsible for the degradation of the aggrecan in the extracellular matrix of joints, in order to hopefully lead to new treatments for osteoarthritis. Only a few inhibitors have been effective in explants or rodent models and thus only a few have reached the clinic ...
Jamal, El Bakali, Helene, Gras-Masse, Lucie, Maingot, Benoit, Deprez, Julie, Dumont, Florence, Leroux, Rebecca, Deprez-Poulain   +6 more
openaire   +2 more sources

Aggrecanase

2006
YAMAJII NOBORU, NISHIMURA KOUICHI, ABE KUNITAKE   +2 more
openaire   +4 more sources

Aggrecanase and cartilage proteoglycan degradation

1999
The loss of aggrecan from cartilage that occurs during normal turnover and joint pathology involves the proteolytic actions of matrix metalloproteinases (MMPs) and “aggrecanase”. This definitive statement is tempered, however, by not knowing precisely which members of the MMP family are involved, and not knowing the molecular identity of aggrecanase ...
openaire   +1 more source

Aggrecanase molecules

2003
AGOSTINO MICHAEL J, RACIE LISA A
openaire   +4 more sources

Effects of RNAi-mediated inhibition of aggrecanase-1 and aggrecanase-2 on rat costochondral chondrocytesin vitro1

Acta Pharmacologica Sinica, 2008
Jun-Bo Tu, Xijing He, Zhuang-Qun Yang
exaly  

Aggrecanase analysis of synovial fluid of temporomandibular joint disorders

Oral Diseases, 2005
Yasunori Okada
exaly