Results 111 to 120 of about 2,239,330 (392)

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Energy-Aware Aggregation of Dynamic Temporal Workload in Data Centers [PDF]

arXiv, 2013
Data center providers seek to minimize their total cost of ownership (TCO), while power consumption has become a social concern. We present formulations to minimize server energy consumption and server cost under three different data center server setups (homogeneous, heterogeneous, and hybrid hetero-homogeneous clusters) with dynamic temporal workload.
arxiv  

Toward incremental FIB aggregation with quick selections (FAQS)

, 2018
Several approaches to mitigating the Forwarding Information Base (FIB) overflow problem were developed and software solutions using FIB aggregation are of particular interest.
Grigoryan, Garegin, Liu, Yaoqing
core   +1 more source

Microbial Extracellular Polymeric Substances: Ecological Function and Impact on Soil Aggregation

Frontiers in Microbiology, 2018
A wide range of microorganisms produce extracellular polymeric substances (EPS), highly hydrated polymers that are mainly composed of polysaccharides, proteins, and DNA. EPS are fundamental for microbial life and provide an ideal environment for chemical
O. Y. Costa, J. Raaijmakers, E. Kuramae
semanticscholar   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Stochastic Aggregation: Rate Equations Approach

, 2000
We investigate a class of stochastic aggregation processes involving two types of clusters: active and passive. The mass distribution is obtained analytically for several aggregation rates.
Aldous D J, Ballobás B, Ben-Naim E, Ben-Naim E, Calogero F, Drake R L, E Ben-Naim, Gradshteyn I S, Krapivsky P L, Leyvraz F, P L Krapivsky, Seinfeld J N, Sheth R K, Spouge J L, Spouge J L, Treat R P, von Smoluchowski M, Wilf H S, Ziff R M   +18 more
core   +2 more sources

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source

Terminal Passivation–Induced Interface Decoupling for High‐Stability Two‐Dimensional Semiconductors

SmartMat
Two‐dimensional (2D) materials, such as MoS2, show exceptional potential for next‐generation electronics. However, the poor stability of these materials, particularly under long‐term operations and high temperature, impedes their practical applications ...
Jinbo He, Jinjian Yan, Tao Xue, Liqian Yuan, Yongxu Hu, Zhongwu Wang, Xiaosong Chen, Yinan Huang, Cheng Han, Liqiang Li, Wenping Hu   +10 more
doaj   +1 more source

Age-Dependent Protein Aggregation Initiates Amyloid-β Aggregation

Frontiers in Aging Neuroscience, 2017
Aging is the most important risk factor for neurodegenerative diseases associated with pathological protein aggregation such as Alzheimer’s disease.
Nicole Groh, Nicole Groh, Anika Bühler, Chaolie Huang, Ka Wan Li, Pim van Nierop, August B. Smit, Marcus Fändrich, Frank Baumann, Della C. David   +9 more
doaj   +1 more source

Spatial control of irreversible protein aggregation [PDF]

arXiv, 2018
Liquid cellular compartments spatially segregate from the cytoplasm and can regulate aberrant protein aggregation, a process linked to several medical conditions, including Alzheimer's and Parkinson's diseases. Yet the mechanisms by which these droplet-like compartments affect protein aggregation remain unknown.
arxiv