Results 111 to 120 of about 134,682 (295)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Comonotone aggregation operators

Rendiconti di Matematica e delle Sue Applicazioni, 2000
Let \((\Omega,{\mathcal A})\) be a measurable space, \(0< F\leq+\infty\), \({\mathcal F}\) the family of all \({\mathcal A}\)-measurable \([0,F]\)-valued functions and \(\oplus\) a pseudo-addition on \([0,F]\). A \(\oplus\)-comonotone aggregation operator is defined as a functional \(L:{\mathcal F}\to [0,F]\) which is idempotent, monotone, continuous ...
BENVENUTI, Pietro, VIVONA, Doretta
openaire   +3 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Induced Interval-Valued Intuitionistic Fuzzy Hybrid Aggregation Operators with TOPSIS Order-Inducing Variables

Journal of Applied Mathematics, 2012
Two induced aggregation operators with novelly designed TOPSIS order-inducing variables are proposed: Induced Interval-valued Intuitionistic Fuzzy Hybrid Averaging (I-IIFHA) operator and Induced Interval-valued Intuitionistic Fuzzy Hybrid Geometric (I ...
Jun-Ling Zhang, Xiao-Wen Qi
doaj   +1 more source

A Novel Method Based on Extended Uncertain 2-tuple Linguistic Muirhead Mean Operators to MAGDM under Uncertain 2-Tuple Linguistic Environment

International Journal of Computational Intelligence Systems, 2019
The present work is focused on multi-attribute group decision-making (MAGDM) problems with the uncertain 2-tuple linguistic information (ULI2–tuple) based on new aggregation operators which can capture interrelationships of attributes by a parameter ...
Yi Liu, Jun Liu, Ya Qin, Yang Xu
doaj   +1 more source

Performance analysis of carrier aggregation for various mobile network implementations scenario based on spectrum allocated

, 2017
Carrier Aggregation (CA) is one of the Long Term Evolution Advanced (LTE-A) features that allow mobile network operators (MNO) to combine multiple component carriers (CCs) across the available spectrum to create a wider bandwidth channel for increasing ...
Kiwoli, Liston, Manasseh, Emmanuel, Sam, Anael   +2 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

How to score alternatives when criteria are scored on an ordinal scale [PDF]

We address in this paper the problem of scoring alternatives when they are evaluated with respect to several criteria on a finite ordinal scale $E$.
Michel Grabisch
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source