Results 51 to 60 of about 128,716 (265)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Emotional Regulation of Displaced Aggression in Provocative Situations among Junior High School Students

Behavioral Sciences
This study investigated the emotion regulation effect of displaced aggression among junior high school students after provocation through two experiments.
Shuang Lin, Gonglu Cheng, Shinan Sun, Mengmeng Feng, Xuejun Bai   +4 more
doaj   +1 more source

The Relation of Violent Video Games to Adolescent Aggression: An Examination of Moderated Mediation Effect

Frontiers in Psychology, 2019
To assess the moderated mediation effect of normative beliefs about aggression and family environment on exposure to violent video games and adolescent aggression, the subjects self-reported their exposure to violent video games, family environment ...
Rong Shao, Rong Shao, Yunqiang Wang
doaj   +1 more source

Aggressive periodontitis

Bratislava Medical Journal, 2020
Horizontally impacted mandibular molars may cause loss of bone, and development of periodontal pockets on the distal root surface of adjacent second molars. The reported patient was confirmed to have aggressive periodontitis. The aim of this presentation is to describe a novel view of a complex treatment approach to promote periodontal healing in a ...
T, Siebert, I, Malachovsky, K, Mikuskova, M, Janickova   +3 more
openaire   +3 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Pattern and characteristics of aggression among adults with psychosis during early inpatient stay in an open ward psychiatric facility: A cross-sectional study

Industrial Psychiatry Journal
Background: Psychiatric inpatient setting is commonly associated with hospital aggression, where it is often perpetrated by patients. An open ward system is less associated with aggression than a closed system.
K. R. Mano Rakesh, Jesson Paulson Illimoottil, Bijesh Yadav, Arun Rachana   +3 more
doaj   +1 more source

Pervasive, hard-wired and male: Qualitative study of how UK adolescents view alcohol-related aggression.

PLoS ONE, 2018
Laboratory studies of alcohol-inexperienced adolescents show that aggression can be primed by alcohol-related stimuli, suggesting that alcohol-related aggression is partly socially learned. Script theory proposes that alcohol-related aggression 'scripts'
Lydia Whitaker, Stephen L Brown, Bridget Young, Richard Fereday, Sarah M Coyne, Pamela Qualter   +5 more
doaj   +1 more source

Aggression in Women: Behavior, Brain and Hormones

Frontiers in Behavioral Neuroscience, 2018
We review the literature on aggression in women with an emphasis on laboratory experimentation and hormonal and brain mechanisms. Women tend to engage in more indirect forms of aggression (e.g., spreading rumors) than other types of aggression.
Thomas F. Denson, Siobhan M. O’Dean, Khandis R. Blake, Joanne R. Beames   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Memory competition: A new experiment to assess unprovoked and provoked aggression

Acta Psychologica
Aggression can be provoked or unprovoked. Most studies on provoked and unprovoked aggression have used questionnaires, making it hard to quantify aggression's costs and benefits.
Xiaoke Qiu, Fenja Ziegler, Susan Chipchase, Bonaventura Majolo   +3 more
doaj   +1 more source