Results 101 to 110 of about 130,584 (298)

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

Advanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen, Zhiquan Liu, Wenmin Wang, Qing Wang, Tia J. Kowal, Fan Zhang, Grzegorz Walkiewicz, Faruk Hossen, Herbert M. Lachman, Jinqiong Zhou, Yiting Wang, Yang Sun   +11 more
wiley   +1 more source

Cross‐scale Material‐Structure Synergy for 2D Metamaterials: Toward Customizable Intelligent Electromagnetic Manipulation in Multiphysics Fields

Advanced Science, EarlyView.
Recent advances in metasurface‐enabled low‐observable technologies are reviewed from the perspective of cross‐scale material–structure synergy. Electromagnetic, thermal, optical, and acoustic stealth are highlighted together with dynamic tuning, programmable coding, data‐driven inverse design, artificial intelligence, multispectral compatibility, and ...
Shuhao Wang, Xing Yang, Liping Liu, Yang Peng, Yangyang Wang, Hualiang Lv   +5 more
wiley   +1 more source

Social interaction, team tacit knowledge and transactive memory: empirical support for the agile approach [PDF]

, 2012
The agile principles of social interaction and tacit knowledge were examined in this survey study of 48 software development teams. It was proposed that that team tacit knowledge is created through frequency and quality of social interactions and through
O'Connor, Rory, Ryan, Sharon, Ryan, Sharon M., Sharon Ryan (9979046), O\u27Connor, Rory V., Rory V. O'Connor (12588769)   +5 more
core   +1 more source

Arthropod‐Inspired Miniature Modular Vibration Direct‐Drive Robot With Untethered Locomotion

Advanced Science, EarlyView.
This work presents an arthropod‐inspired untethered miniature modular vibration direct‐drive robot. By utilizing standardized driving units and nested locking interfaces, on‐demand reconfiguration into quadruped, hexapod, octopod, and circular morphologies is achieved.
Shijing Zhang, Ziteng Liu, Youwei Liu, Dehong Wang, Yingxiang Liu   +4 more
wiley   +1 more source

Recent Advances in Programmable Metasurfaces and Meta‐Devices

Advanced Electronic Materials, EarlyView.
Programmable metasurfaces enable various novel functionalities by dynamically tuning electromagnetic wavefronts. This article provides a comprehensive review of recent advances in microwave and terahertz programmable metasurfaces, covering electrical, thermal, optical, and mechanical control mechanisms.
Linda Shao, Chong He, Nan Wang, Liming Si, Weiren Zhu   +4 more
wiley   +1 more source

Effects of manual therapy and inclined board standing on low back pain: a pilot study

Journal of University Medical & Dental College
BACKGROUND & OBJECTIVE:  Low back pain (LBP), especially mechanical in nature, affects approximately 577 million people globally. Its incidence is expected to rise due to an ageing population.
Muhammad Hafeez, Muhammad Zia Ul Haq , Shabana Rahim   +2 more
doaj   +1 more source

Low‐Field Giant Dielectric Tunability by Polaron‐Mediated Interfacial Polarization in Pulsed‐Laser‐Deposited‐Nanocrystalline/Amorphous Composite BaTiO3 Thin Films

Advanced Electronic Materials, EarlyView.
Comparison of tunability efficiency between vacuum‐deposited PLD‐BTO films grown at Td = 550°C in the present study and representative previous reports. ABSTRACT Electrically tunable dielectric thin films are essential components for next‐generation low‐voltage electronic devices.
Shinya Kondo, Taichi Murakami, Loick Pichon, Joël Leblanc‐Lavoie, Takashi Teranishi, Akira Kishimoto, Tomoaki Yamada, My Ali El Khakani   +7 more
wiley   +1 more source

Emergence of Agile Methods: Perceptions from Software Practitioners in Malaysia

Agile methods are an established process for developing software nowadays. There is, however, less evidence on its usage among software practitioners in Malaysia.
Gravell, Andrew, Wills, Gary, Asnawi, Ani Liza   +2 more
core   +1 more source

Physics Informed Generative Surrogate Learning for Full Wave Validated Real Time Beamforming in Programmable Metasurfaces

Advanced Electronic Materials, EarlyView.
A physics‐guided generative surrogate framework is developed for programmable metasurface beamforming. Mode‐conditioned binary state generation, aperture‐physics prediction, routed residual correction, NSGA‐II optimization, and CST validation are combined to support fast candidate screening and full‐wave beam refinement across single‐beam, dual‐beam ...
Wenqian Liu, Weidong Chen, Chang Chen, Xiang Zhang, Sensong An   +4 more
wiley   +1 more source