Results 1 to 10 of about 11,679,950 (380)
Inflammation and aging: signaling pathways and intervention therapies
Signal Transduction and Targeted Therapy, 2023 Aging is characterized by systemic chronic inflammation, which is accompanied by cellular senescence, immunosenescence, organ dysfunction, and age-related diseases.
Xia Li +5 more
semanticscholar +1 more source
Scientific Reports, 2022 Canine cognitive dysfunction (CCD) is a neurodegenerative disease in aging dogs. It has been described previously in relatively small cohorts of dogs using multiple different rating scales.
Sarah Yarborough +3 more
doaj +1 more source
Implementation and review of the care ecosystem in an integrated healthcare system
BMC Geriatrics, 2023 Background and objectives The University of California, San Francisco Memory and Aging Center (UCSF-MAC) led the development and tested a collaborative care model delivered by lay care team navigators (CTNs) with support from a multidisciplinary team ...
Michael H. Rosenbloom +10 more
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Coenzyme A binding sites induce proximal acylation across protein families
Scientific Reports, 2023 Lysine Nɛ-acylations, such as acetylation or succinylation, are post-translational modifications that regulate protein function. In mitochondria, lysine acylation is predominantly non-enzymatic, and only a specific subset of the proteome is acylated ...
Chris Carrico +8 more
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Impact of atrial fibrillation on the cognitive decline in Alzheimer’s disease
Alzheimer’s Research & Therapy, 2023 Background Atrial fibrillation (AF) is a strong risk factor for Alzheimer’s disease (AD) independent of ischemic stroke. However, the clinicopathological impact of AF on the severity of AD has not been well elucidated.
Taizen Nakase +8 more
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Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
Signal Transduction and Targeted Therapy, 2022 Aging is a gradual and irreversible pathophysiological process. It presents with declines in tissue and cell functions and significant increases in the risks of various aging-related diseases, including neurodegenerative diseases, cardiovascular diseases,
Jun Guo +6 more
semanticscholar +1 more source
Nature Communications, 2021 The serine protease TMPRSS2 primes SARS-CoV-2 glycoprotein for cell entry. Here, the authors perform a screen to identify drugs that reduce TMPRSS2 expression and find that halofuginone modulates proteasome-mediated degradation of TMPRSS2 and reduces ...
Yanwen Chen +16 more
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Epigenetic regulation of aging: implications for interventions of aging and diseases
Signal Transduction and Targeted Therapy, 2022 Aging is accompanied by the decline of organismal functions and a series of prominent hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic changes include DNA methylation, histone modification, chromatin remodeling ...
Kang-Xin Wang +9 more
semanticscholar +1 more source
Expert consensus on neuroimaging diagnosis of dementia and cognitive impairment (2023) [PDF]
Zhenduanxue lilun yu shijianFor patients with cognitive impairment as the main clinical manifestation, structural MRI (or CT instead) should be performed first to clarify intracranial lesions and brain atrophy.
Aging and Cognitive Impairment Branch of Shanghai Society of Aging and Degenerative Diseases
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Oxidative stress, aging, and diseases
Clinical Interventions in Aging, 2018 Reactive oxygen and nitrogen species (RONS) are produced by several endogenous and exogenous processes, and their negative effects are neutralized by antioxidant defenses.
Ilaria Liguori +10 more
semanticscholar +1 more source