Results 1 to 10 of about 11,118,482 (404)
Scientific Reports, 2022 Canine cognitive dysfunction (CCD) is a neurodegenerative disease in aging dogs. It has been described previously in relatively small cohorts of dogs using multiple different rating scales.
Sarah Yarborough +3 more
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Implementation and review of the care ecosystem in an integrated healthcare system
BMC Geriatrics, 2023 Background and objectives The University of California, San Francisco Memory and Aging Center (UCSF-MAC) led the development and tested a collaborative care model delivered by lay care team navigators (CTNs) with support from a multidisciplinary team ...
Michael H. Rosenbloom +10 more
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Impact of atrial fibrillation on the cognitive decline in Alzheimer’s disease
Alzheimer’s Research & Therapy, 2023 Background Atrial fibrillation (AF) is a strong risk factor for Alzheimer’s disease (AD) independent of ischemic stroke. However, the clinicopathological impact of AF on the severity of AD has not been well elucidated.
Taizen Nakase +8 more
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Nature Communications, 2021 The serine protease TMPRSS2 primes SARS-CoV-2 glycoprotein for cell entry. Here, the authors perform a screen to identify drugs that reduce TMPRSS2 expression and find that halofuginone modulates proteasome-mediated degradation of TMPRSS2 and reduces ...
Yanwen Chen +16 more
doaj +1 more source
Coenzyme A binding sites induce proximal acylation across protein families
Scientific Reports, 2023 Lysine Nɛ-acylations, such as acetylation or succinylation, are post-translational modifications that regulate protein function. In mitochondria, lysine acylation is predominantly non-enzymatic, and only a specific subset of the proteome is acylated ...
Chris Carrico +8 more
doaj +1 more source
On the Precision of Full-spectrum Fitting of Stellar Populations. III. Identifying Age Spreads [PDF]
, 2021 In this third paper of a series on the precision of obtaining ages of stellar populations using the full spectrum fitting technique, we examine the precision of this technique in deriving possible age spreads within a star cluster. We test how well an internal age spread can be resolved as a function of cluster age, population mass fraction, and signal-
arxiv +1 more source
Expert consensus on neuroimaging diagnosis of dementia and cognitive impairment (2023) [PDF]
Zhenduanxue lilun yu shijianFor patients with cognitive impairment as the main clinical manifestation, structural MRI (or CT instead) should be performed first to clarify intracranial lesions and brain atrophy.
Aging and Cognitive Impairment Branch of Shanghai Society of Aging and Degenerative Diseases
doaj +1 more source
How financial incentives induce disability insurance recipients to return to work [PDF]
, 2014 Using a local randomized experiment that arises from a sharp discontinuity in Disability Insurance (DI) policy in Norway, we provide transparent and credible identification of how financial incentives induce DI recipients to return to work.
Kostøl, AR, Mogstad, M
core +1 more source
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Proceedings of the National Academy of Sciences of the United States of America, 1995 Normal somatic cells invariably enter a state of irreversibly arrested growth and altered function after a finite number of divisions. This process, termed replicative senescence, is thought to be a tumor-suppressive mechanism and an underlying cause of ...
Goberdhan P Dimri +9 more
semanticscholar +1 more source
Aging Parents & Dilemmas of Their Children [PDF]
, 1981 Hogg Foundation for Mental ...
Adelberg, Bettina +2 more
core +1 more source