Results 1 to 10 of about 2,225,048 (294)

Evaluation of cognitive function in the Dog Aging Project: associations with baseline canine characteristics

Scientific Reports, 2022
Canine cognitive dysfunction (CCD) is a neurodegenerative disease in aging dogs. It has been described previously in relatively small cohorts of dogs using multiple different rating scales.
Sarah Yarborough, Annette Fitzpatrick, Stephen M. Schwartz, Dog Aging Project Consortium   +3 more
doaj   +1 more source

Implementation and review of the care ecosystem in an integrated healthcare system

BMC Geriatrics, 2023
Background and objectives The University of California, San Francisco Memory and Aging Center (UCSF-MAC) led the development and tested a collaborative care model delivered by lay care team navigators (CTNs) with support from a multidisciplinary team ...
Michael H. Rosenbloom, Bhavani Kashyap, Ana Diaz-Ochoa, Jan Karrmann, Aleta Svitak, Jennifer Finstad, Ann Brombach, Ann Sprandel, Leah Hanson, Sarah Dulaney, Katherine Possin   +10 more
doaj   +1 more source

Coenzyme A binding sites induce proximal acylation across protein families

Scientific Reports, 2023
Lysine Nɛ-acylations, such as acetylation or succinylation, are post-translational modifications that regulate protein function. In mitochondria, lysine acylation is predominantly non-enzymatic, and only a specific subset of the proteome is acylated ...
Chris Carrico, Andrew Cruz, Marius Walter, Jesse Meyer, Cameron Wehrfritz, Samah Shah, Lei Wei, Birgit Schilling, Eric Verdin   +8 more
doaj   +1 more source

Impact of atrial fibrillation on the cognitive decline in Alzheimer’s disease

Alzheimer’s Research & Therapy, 2023
Background Atrial fibrillation (AF) is a strong risk factor for Alzheimer’s disease (AD) independent of ischemic stroke. However, the clinicopathological impact of AF on the severity of AD has not been well elucidated.
Taizen Nakase, Yasuko Tatewaki, Benjamin Thyreau, Hayato Odagiri, Naoki Tomita, Shuzo Yamamoto, Yumi Takano, Michiho Muranaka, Yasuyuki Taki   +8 more
doaj   +1 more source

A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry

Nature Communications, 2021
The serine protease TMPRSS2 primes SARS-CoV-2 glycoprotein for cell entry. Here, the authors perform a screen to identify drugs that reduce TMPRSS2 expression and find that halofuginone modulates proteasome-mediated degradation of TMPRSS2 and reduces ...
Yanwen Chen, Travis B. Lear, John W. Evankovich, Mads B. Larsen, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Laura Salminen, Daniel P. Camarco, Karina C. Lockwood, Ferhan Tuncer, Jie Liu, Michael M. Myerburg, John F. McDyer, Yuan Liu, Toren Finkel, Bill B. Chen   +16 more
doaj   +1 more source

Expert consensus on neuroimaging diagnosis of dementia and cognitive impairment (2023) [PDF]

Zhenduanxue lilun yu shijian
For patients with cognitive impairment as the main clinical manifestation, structural MRI (or CT instead) should be performed first to clarify intracranial lesions and brain atrophy.
Aging and Cognitive Impairment Branch of Shanghai Society of Aging and Degenerative Diseases
doaj   +1 more source

Effects of repetitive Transcranial Magnetic Stimulation in aged rats depend on pre-treatment cognitive status: Toward individualized intervention for successful cognitive aging

Brain Stimulation, 2021
Background: Repetitive Transcranial Magnetic Stimulation (rTMS) has shown initial promise in combating age-related cognitive decline and dementia. The nature and severity of cognitive aging, however, varies markedly between individuals.
Marina Weiler, Perla Moreno-Castilla, Hannah M. Starnes, Edward L.R. Melendez, Kevin C. Stieger, Jeffrey M. Long, Peter R. Rapp   +6 more
doaj   +1 more source

Correction for retest effects across repeated measures of cognitive functioning: a longitudinal cohort study of postoperative delirium

BMC Medical Research Methodology, 2018
Background Few studies have compared methods to correct for retest effects or practice effects in settings where an acute event could influence test performance, such as major surgery.
Annie M. Racine, Yun Gou, Tamara G. Fong, Edward R. Marcantonio, Eva M. Schmitt, Thomas G. Travison, Sharon K. Inouye, Richard N. Jones   +7 more
doaj   +1 more source

Double-Blind Placebo-Controlled Pilot Investigation of the Safety of a Single Dose of Rapid-Acting Intranasal Insulin in Down Syndrome

Drugs in R&D, 2020
Background Individuals with Down syndrome are likely to develop clinical and neuropathological brain changes resembling Alzheimer’s disease dementia by the ages of 35–40 years.
Michael Rosenbloom, Terry Barclay, Justin Johnsen, Lauren Erickson, Aleta Svitak, Maria Pyle, William Frey, Leah R. Hanson   +7 more
doaj   +1 more source

The Role of Inflammation after Surgery for Elders (RISE) study: Study design, procedures, and cohort profile

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction The Role of Inflammation after Surgery for Elders study correlates novel inflammatory markers measured in blood, cerebrospinal fluid (CSF) assays, and [11C]‐PBR28 positron‐emission tomography imaging.
Tammy T. Hshieh, Sarinnapha M. Vasunilashorn, Madeline L. D'Aquila, Steven E. Arnold, Bradford C. Dickerson, Tamara G. Fong, Richard N. Jones, Edward R. Marcantonio, Eva M. Schmitt, Guoquan Xu, Yun Gou, Fan Chen, Lisa J. Kunze, Kamen V. Vlassakov, Ayesha R. Abdeen, Jeffrey K. Lange, Brandon E. Earp, Alexandra Touroutoglou, Becky C. Carlyle, Pia Kivisakk‐Webb, Thomas G. Travison, Simon T. Dillon, Towia A. Libermann, Sharon K. Inouye, RISE Study Group, Sharon K. Inouye, Steven Arnold, Bradford Dickerson, Tamara Fong, Richard Jones, Towia A. Libermann, Edward R. Marcantonio, Thomas Travison, Becky C. Carlyle, Michele Cavallari, Simon T. Dillon, Jacob Hooker, Tammy Hshieh, Savannah Kandigian, Pia Kivisakk‐Webb, Long Ngo, Hasan Otu, Eva M. Schmitt, Alexandra Touroutoglou, Bianca Trombetta, Sarinnapha Vasunilashorn, Ayesha Abdeen, Douglas Ayres, Brandon Earp, Jeffrey Lange, Gregory Brick, Antonia Chen, Robert Davis, Jacob Drew, Richard Iorio, Fulton Kornack, Michael Weaver, Anthony Webber, Richard Wilk, Lisa Kunze, David Shaff, Kamen Vlassakov, Brett Armstrong, Angelee Banda, Sylvie Bertrand, Madeline D'Aquila, Jacqueline Gallagher, Baileigh Hightower, Shannon Malloy, Jacqueline Nee, Chloe Nobuhara, Abigail Overstreet, Annie Racine, David Urick, Guoquan Xu, Grae Arabasz, Michael Brickhouse, Regan Butterfield, Shirley Hsu, Sara Makaretz, Judit Sore, Fan Chen, Yun Gou, Douglas Tommet, Sabrina Carretie, Ted Gruen, Katherine Tasker   +86 more
doaj   +1 more source