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Etiological Factors and Premature Aging
JAMA, 1962AGING IS an interesting subject which is receiving increasing attention in many fields. There is an ever-enlarging body of information which indicates that many of the phenomena which were previously regarded as "natural" processes resulting from old age are actually due to specific disease processes.
John M. Knox +2 more
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2012
Hutchinson-Gilford progeria syndrome and Werner syndrome are two of the best characterized human progeroid diseases with clinical features mimicking physiological aging at an early age. Both disorders have been the focus of intense research in recent years since they might provide insights into the pathology of normal human aging.
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Hutchinson-Gilford progeria syndrome and Werner syndrome are two of the best characterized human progeroid diseases with clinical features mimicking physiological aging at an early age. Both disorders have been the focus of intense research in recent years since they might provide insights into the pathology of normal human aging.
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Molecular and Cellular Biochemistry, 2006
Guanidinosuccinic acid is an aberrant metabolite isolated 40 years ago in the blood and urine of uremic subjects and a suspect in the toxicity associated with renal failure. It plays a minor role in the bleeding diathesis of uremia, contributes to the methyl group deficiency of dialysis patients, and is a factor in the premature atherosclerosis of end ...
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Guanidinosuccinic acid is an aberrant metabolite isolated 40 years ago in the blood and urine of uremic subjects and a suspect in the toxicity associated with renal failure. It plays a minor role in the bleeding diathesis of uremia, contributes to the methyl group deficiency of dialysis patients, and is a factor in the premature atherosclerosis of end ...
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Searching for clues to premature aging
Trends in Endocrinology & Metabolism, 2002Hutchinson-Gilford Progeria syndrome is a rare developmental disorder affecting most of the organ systems in a manner that mimics natural aging but at a markedly accelerated rate. A recent workshop at the NIH, aimed at further understanding the aging process, took an in-depth look at this complex syndrome.
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Science, 2018
Premature Aging Cells from patients with Hutchinson-Gilford progeria syndrome (HGPS) have defects in nuclear architecture that lead to premature cellular senescence. Larrieu et al. investigated the mechanisms by which a small molecule called remodelin improves the phenotype of HGPS cells (see the Focus by Wilson).
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Premature Aging Cells from patients with Hutchinson-Gilford progeria syndrome (HGPS) have defects in nuclear architecture that lead to premature cellular senescence. Larrieu et al. investigated the mechanisms by which a small molecule called remodelin improves the phenotype of HGPS cells (see the Focus by Wilson).
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2012
Cockayne Syndrome – De Barsy Syndrome – Hallermann-Streiff Syndrome – Hutchinson-Gilford Progeria – Werner ...
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Cockayne Syndrome – De Barsy Syndrome – Hallermann-Streiff Syndrome – Hutchinson-Gilford Progeria – Werner ...
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Growth Hormone and Premature Ageing
Nature, 1973IT has often been suggested that the immune system may be involved in ageing1–4 Fabris et al.5 claim that such immune deficiencies are caused by inadequate stimulation of the lymphoid system by growth hormone (GH). They compared mice with inherited pituitary dwarfism (homozygotes for Snell's dwarf mutation, dw) with normal mice from the same stock. The
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Premature Birth and Age at Onset of Puberty
Epidemiology, 2012Premature birth is associated with poor metabolic health in both sexes, potentially via earlier pubertal timing.We examined the associations of gestational age and premature birth (< 37 weeks gestation) with age at onset of puberty (Tanner stage II for breast or genitalia development).
Lam, TH +3 more
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Transcription-coupled repair and premature ageing
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2005During the past decades, several cellular pathways have been discovered to be connected with the ageing process. These pathways, which either suppress or enhance the ageing process, include regulation of the insulin/growth hormone axis, pathways involved with caloric restriction, ROS metabolism and DNA repair.
Jaan-Olle Andressoo +1 more
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Chronic kidney disease and premature ageing
Nature Reviews Nephrology, 2014Chronic kidney disease (CKD) shares many phenotypic similarities with other chronic diseases, including heart failure, chronic obstructive pulmonary disease, HIV infection and rheumatoid arthritis. The most apparent similarity is premature ageing, involving accelerated vascular disease and muscle wasting.
Peter Kotanko +4 more
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