Results 11 to 20 of about 2,198,545 (274)
Scientific Reports, 2022 Canine cognitive dysfunction (CCD) is a neurodegenerative disease in aging dogs. It has been described previously in relatively small cohorts of dogs using multiple different rating scales.
Sarah Yarborough +3 more
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Implementation and review of the care ecosystem in an integrated healthcare system
BMC Geriatrics, 2023 Background and objectives The University of California, San Francisco Memory and Aging Center (UCSF-MAC) led the development and tested a collaborative care model delivered by lay care team navigators (CTNs) with support from a multidisciplinary team ...
Michael H. Rosenbloom +10 more
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Coenzyme A binding sites induce proximal acylation across protein families
Scientific Reports, 2023 Lysine Nɛ-acylations, such as acetylation or succinylation, are post-translational modifications that regulate protein function. In mitochondria, lysine acylation is predominantly non-enzymatic, and only a specific subset of the proteome is acylated ...
Chris Carrico +8 more
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Impact of atrial fibrillation on the cognitive decline in Alzheimer’s disease
Alzheimer’s Research & Therapy, 2023 Background Atrial fibrillation (AF) is a strong risk factor for Alzheimer’s disease (AD) independent of ischemic stroke. However, the clinicopathological impact of AF on the severity of AD has not been well elucidated.
Taizen Nakase +8 more
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Nature Communications, 2021 The serine protease TMPRSS2 primes SARS-CoV-2 glycoprotein for cell entry. Here, the authors perform a screen to identify drugs that reduce TMPRSS2 expression and find that halofuginone modulates proteasome-mediated degradation of TMPRSS2 and reduces ...
Yanwen Chen +16 more
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On the Precision of Full-spectrum Fitting of Stellar Populations. III. Identifying Age Spreads [PDF]
, 2021 In this third paper of a series on the precision of obtaining ages of stellar populations using the full spectrum fitting technique, we examine the precision of this technique in deriving possible age spreads within a star cluster. We test how well an internal age spread can be resolved as a function of cluster age, population mass fraction, and signal-
arxiv +1 more source
Expert consensus on neuroimaging diagnosis of dementia and cognitive impairment (2023) [PDF]
Zhenduanxue lilun yu shijianFor patients with cognitive impairment as the main clinical manifestation, structural MRI (or CT instead) should be performed first to clarify intracranial lesions and brain atrophy.
Aging and Cognitive Impairment Branch of Shanghai Society of Aging and Degenerative Diseases
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Dynamical network stability analysis of multiple biological ages provides a framework for understanding the aging process [PDF]
, 2023 Widespread interest in non-destructive biomarkers of aging has led to a curse of plenty: a multitude of biological ages that each proffers a 'true' health-adjusted age of an individual. While each measure provides salient information on the aging process, they are each univariate, in contrast to the "hallmark" and "pillar" theories of aging which are ...
arxiv +1 more source
BMC Medical Research Methodology, 2018 Background Few studies have compared methods to correct for retest effects or practice effects in settings where an acute event could influence test performance, such as major surgery.
Annie M. Racine +7 more
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Drugs in R&D, 2020 Background Individuals with Down syndrome are likely to develop clinical and neuropathological brain changes resembling Alzheimer’s disease dementia by the ages of 35–40 years.
Michael Rosenbloom +7 more
doaj +1 more source