Results 11 to 20 of about 12,311,713 (381)
Inflammation and aging: signaling pathways and intervention therapies
Signal Transduction and Targeted Therapy, 2023 Aging is characterized by systemic chronic inflammation, which is accompanied by cellular senescence, immunosenescence, organ dysfunction, and age-related diseases.
Xia Li +5 more
semanticscholar +1 more source
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
Signal Transduction and Targeted Therapy, 2022 Aging is a gradual and irreversible pathophysiological process. It presents with declines in tissue and cell functions and significant increases in the risks of various aging-related diseases, including neurodegenerative diseases, cardiovascular diseases,
Jun Guo +6 more
semanticscholar +1 more source
Mitochondrial dysfunction in cell senescence and aging
Journal of Clinical Investigation, 2022 Mitochondrial dysfunction and cell senescence are hallmarks of aging and are closely interconnected. Mitochondrial dysfunction, operationally defined as a decreased respiratory capacity per mitochondrion together with a decreased mitochondrial membrane ...
S. Miwa +3 more
semanticscholar +1 more source
An epigenetic biomarker of aging for lifespan and healthspan
bioRxiv, 2018 Identifying reliable biomarkers of aging is a major goal in geroscience. While the first generation of epigenetic biomarkers of aging were developed using chronological age as a surrogate for biological age, we hypothesized that incorporation of ...
M. Levine +17 more
semanticscholar +1 more source
Epigenetic regulation of aging: implications for interventions of aging and diseases
Signal Transduction and Targeted Therapy, 2022 Aging is accompanied by the decline of organismal functions and a series of prominent hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic changes include DNA methylation, histone modification, chromatin remodeling ...
Kang-Xin Wang +9 more
semanticscholar +1 more source
Science China Life Sciences, 2022 Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased susceptibility to death.
Yusheng Cai +52 more
semanticscholar +1 more source
Oxidative stress, aging, and diseases
Clinical Interventions in Aging, 2018 Reactive oxygen and nitrogen species (RONS) are produced by several endogenous and exogenous processes, and their negative effects are neutralized by antioxidant defenses.
Ilaria Liguori +10 more
semanticscholar +1 more source
Nox2 dependent redox-regulation of microglial response to amyloid-β stimulation and microgliosis in aging [PDF]
, 2020 Microglia express constitutively a Nox2 enzyme that is involved in neuroinflammation by the generation of reactive oxygen species (ROS). Amyloid β (Aβ) plays a crucial role in Alzheimer’s disease.
Fan, Lampson M. +4 more
core +2 more sources
BMC Medical Research Methodology, 2018 Background Few studies have compared methods to correct for retest effects or practice effects in settings where an acute event could influence test performance, such as major surgery.
Annie M. Racine +7 more
doaj +1 more source
The light and shadow of senescence and inflammation in cardiovascular pathology and regenerative medicine [PDF]
, 2017 Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised ...
Cavarretta, Elena +9 more
core +4 more sources