Results 1 to 10 of about 19,284 (137)
C-terminal tagging impairs AGO2 function [PDF]
RNA Biology, 2023 MicroRNA-mediated gene silencing is a conserved mechanism of post-transcriptional gene regulation across metazoans. It depends on base pairing between small RNAs and mRNAs, and on protein complexes including the RNA-induced silencing complex (RISC ...
Kunal M. Shah +7 more
doaj +3 more sources
KRAS Engages AGO2 to Enhance Cellular Transformation [PDF]
Cell Reports, 2016 Oncogenic mutations in RAS provide a compelling yet intractable therapeutic target. Using co-immunoprecipitation mass spectrometry, we uncovered an interaction between RAS and Argonaute 2 (AGO2).
Sunita Shankar +16 more
doaj +6 more sources
KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes [PDF]
Cell Reports, 2016 Secretion of RNAs in extracellular vesicles is a newly recognized form of intercellular communication. A potential regulatory protein for microRNA (miRNA) secretion is the critical RNA-induced silencing complex (RISC) component Argonaute 2 (Ago2).
Andrew J. McKenzie +7 more
doaj +3 more sources
Dual regulation of Arabidopsis AGO2 by arginine methylation [PDF]
Nature Communications, 2019 AGO2 is a core component of the RNAi machinery and contributes to plant immunity during bacterial infection. Here the authors show that AGO2 activity is suppressed by arginine methylation which not only promotes AGO2 degradation but also recruits TSN ...
Po Hu +6 more
doaj +6 more sources
p63, a key regulator of Ago2, links to the microRNA-144 cluster
Cell Death and Disease, 2022 As a key component of the RNA-induced silencing complex (RISC), Argonaute2 (Ago2) exhibits a dual function regulatory role in tumor progression. However, the mechanistic basis of differential regulation remains elusive.
Benfan Wang +7 more
doaj +4 more sources
Quantifying Argonaute 2 (Ago2) expression to stratify breast cancer [PDF]
BMC Cancer, 2019 Background Argonaute-2 (Ago2) is an essential component of microRNA biogenesis implicated in tumourigenesis. However Ago2 expression and localisation in breast cancer remains undetermined.
M.C. Casey +11 more
doaj +4 more sources
PSMC3 promotes RNAi by maintaining AGO2 stability through USP14
Cellular & Molecular Biology Letters, 2022 Background Argonaute 2 (AGO2), the only protein with catalytic activity in the human Argonaute family, is considered as a key component of RNA interference (RNAi) pathway.
Yan Jia +7 more
doaj +3 more sources
Argonaute2 modulates megakaryocyte development and sex-specific control of platelet protein expression and reactivity [PDF]
Scientific ReportsPlatelets are enriched in miRNAs and harbor Ago2 as the principal RNA silencing Argonaute. However, roles in thrombopoiesis and platelet function remain poorly understood.
Sophia Lazar +6 more
doaj +2 more sources
AGO2 phosphorylation by c-Src kinase promotes tumorigenesis
Neoplasia: An International Journal for Oncology Research, 2020 Numerous studies have reported that c-Src is highly expressed with high tyrosine kinase activity in a variety of tumors. However, it remains unclear whether c-Src contributes to the miRNA pathway.
Tianqi Liu +9 more
doaj +4 more sources
AGO1 and AGO2 act redundantly in miR408-mediated Plantacyanin regulation. [PDF]
PLoS ONE, 2011 BackgroundIn Arabidopsis, AGO1 and AGO2 associate with small RNAs that exhibit a Uridine and an Adenosine at their 5' end, respectively. Because most plant miRNAs have a 5'U, AGO1 plays many essential roles in miRNA-mediated regulation of development and
Nicolas Maunoury, Hervé Vaucheret
doaj +8 more sources