Quantifying Argonaute 2 (Ago2) expression to stratify breast cancer [PDF]
BMC Cancer, 2019 Background Argonaute-2 (Ago2) is an essential component of microRNA biogenesis implicated in tumourigenesis. However Ago2 expression and localisation in breast cancer remains undetermined.
M.C. Casey +11 more
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C-terminal tagging impairs AGO2 function [PDF]
RNA Biology, 2023 MicroRNA-mediated gene silencing is a conserved mechanism of post-transcriptional gene regulation across metazoans. It depends on base pairing between small RNAs and mRNAs, and on protein complexes including the RNA-induced silencing complex (RISC ...
Kunal M. Shah +7 more
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Dual regulation of Arabidopsis AGO2 by arginine methylation [PDF]
Nature Communications, 2019 AGO2 is a core component of the RNAi machinery and contributes to plant immunity during bacterial infection. Here the authors show that AGO2 activity is suppressed by arginine methylation which not only promotes AGO2 degradation but also recruits TSN ...
Po Hu +6 more
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Reactivity of human AGO2 monoclonal antibody 11A9 with the SWI/SNF complex: A case study for rigorously defining antibody selectivity [PDF]
Scientific Reports, 2017 In this study, we originally aimed to characterize the potential role of Argonaute 2 (AGO2) in the nucleus, a key protein of the miRNA machinery. We combined Chromatin Immunoprecipitation (ChIP) with high throughput sequencing (ChIP-seq) and quantitative
Roderick A. P. M. van Eijl +3 more
doaj +2 more sources
Ras Homolog Enriched in Brain Protein Reverses Amyloid Beta-Induced Escape of Inflammatory Cytokine mRNAs From Immunoisolated RNA Processing Bodies of Glioblastoma Cells. [PDF]
FASEB JA detergent‐based method, combined with immunoprecipitation using an anti‐P‐body component‐specific antibody, was used to isolate RNAs associated with RNA processing bodies (PBs) from both neuronal and glial cells. In neurons, β‐amyloid oligomers helped to trap specific mRNAs related to neuronal differentiation into PBs.
Ray S, Mukherjee K, Bhattacharyya SN.
europepmc +2 more sources
The Expression of AGO2 and DGCR8 in Idiopathic Sudden Sensorineural Hearing Loss [PDF]
Clinical and Experimental Otorhinolaryngology, 2014 ObjectivesThe microRNAs have been implicated in the development and function of the inner ear, especially in contribution to hearing. However, the impact of idiopathic sudden sensorineural hearing loss (SSNHL) on expression of miRNA biogenesis-related ...
Soon Yong Han +4 more
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Identification of a novel <i>AGO2</i> variant causing LESKRES in a Chinese family with intellectual disability. [PDF]
Front GenetYang S, Song W, Yan Y.
europepmc +3 more sources
Frontiers in Pharmacology, 2021 Dysregulation of microRNA (miRNA) biogenesis is involved in drug addiction. Argonaute2 (Ago2), a specific splicing protein involved in the generation of miRNA, was found to be dysregulated in the nucleus accumbens (NAc) of methamphetamine (METH ...
Dan Liu +18 more
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Frontiers in Plant Science, 2020 Argonaute 2 (AGO2)-mediated role in plant defense against fungal pathogens remains largely unknown. In this study, integrated miRNAome and transcriptome analysis employing ago2 mutant was performed to reveal AGO2-associated miRNAs and defense responses ...
Jia-Yi Cao +3 more
doaj +1 more source
Argonaute-2 protects the neurovascular unit from damage caused by systemic inflammation
Journal of Neuroinflammation, 2022 Background The brain vasculature plays a pivotal role in the inflammatory process by modulating the interaction between blood cells and the neurovascular unit.
Marta Machado-Pereira +4 more
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