Results 91 to 100 of about 20,279 (201)

Tryptophan As a New Member of RNA‐Induced Silencing Complexes Prevents Colon Cancer Liver Metastasis

Advanced Science
Essential amino acids (EAA) and microRNAs (miRs) control biological activity of a cell. Whether EAA regulates the activity of miR has never been demonstrated. Here, as proof‐of‐concept, a tryptophan (Trp, an EAA) complex containing Argonaute 2 (Ago2) and
Fangyi Xu, Yi Ren, Yun Teng, Jingyao Mu, Jie Tang, Kumaran Sundaram, Lifeng Zhang, Juw Won Park, Jae Yeon Hwang, Jun Yan, Gerald Dryden, Huang‐Ge Zhang   +11 more
doaj   +1 more source

N6‐Methyladenosine Modification of circIST1 Promotes Hypoxia‐Inducible Factor α–mediated Glycolysis and Progression in Hepatocellular Carcinoma

MedComm, Volume 7, Issue 1, January 2026.
We identified first time a critical m6A modification of circIST1 on miR‐140‐3p/miR‐182‐HIF1α regulatory network involved in the HCC progression and tumor glycolysis, gaining mechanistic insights into the function of circRNAs in HCC progression. ABSTRACT The involvement of circular RNAs (circRNAs) have been well‐documented in various cancers, including ...
Yangyang Zhan, Zhongmin Wang, Fei Teng, Qian Ding, Lei Lv, Fangyuan Xie, Yueying Huang, Xue Jiang, Dan Zheng, Xiaoying Ge, Shuqun Cheng, Yizhun Zhu, Leilei Bao   +12 more
wiley   +1 more source

RNAi‐mediated gene silencing of a 26S proteasome subunit increases mortality of the Japanese beetle Popillia japonica

Pest Management Science, Volume 82, Issue 1, Page 1066-1078, January 2026.
We propose the regulatory particle non‐ATPase subunit 6 of the 26S proteasome as a first good promising RNA interference target candidate to control the Japanese beetle Popillia japonica. This will help to optimize a double‐stranded RNA insecticide against this priority pest with low off‐target effects on pollinators on a gene sequence‐based prediction.
Giulia Lucetti, Simona Abbà, Gabriele Pesavento, Elena Fanelli, Francesca De Luca, Elia Battagini, Stefano Cazzaniga, Matteo Ballottari, Diletta Frizzon, Nicola Mori, Luciana Galetto   +10 more
wiley   +1 more source

Natural variation of the amino-terminal glutamine-rich domain in Drosophila argonaute2 is not associated with developmental defects.

PLoS ONE, 2010
The Drosophila argonaute2 (ago2) gene plays a major role in siRNA mediated RNA silencing pathways. Unlike mammalian Argonaute proteins, the Drosophila protein has an unusual amino-terminal domain made up largely of multiple copies of glutamine-rich ...
Daniel Hain, Brian R Bettencourt, Katsutomo Okamura, Tibor Csorba, Wibke Meyer, Zhigang Jin, Jason Biggerstaff, Haruhiko Siomi, Gyorgy Hutvagner, Eric C Lai, Michael Welte, H-Arno J Müller   +11 more
doaj   +1 more source

Pepino Mosaic Virus: A Globally Important Tomato Pathogen and a Rising Model in Molecular Virology

Molecular Plant Pathology, Volume 27, Issue 1, January 2026.
Pepino mosaic virus (PepMV) is a globally important tomato pathogen causing fruit quality losses. It comprises multiple genetic types and spreads via seed and mechanical contact. Lacking resistant cultivars, management relies on cross‐protection. PepMV–tomato interactions provide a valuable model for studying virus–plant molecular mechanisms and ...
Jesús R. Úbeda, Livia Donaire, Cristina Alcaide, Miguel A. Aranda   +3 more
wiley   +1 more source

Evaluating the diagnostic value of Argonaute 2 gene expression changes in patients with colorectal cancer [PDF]

فصلنامه ابن سینا, 2018
Background: The protein encoded by argonaute 2 gene (AGO2) plays a critical role in micro-RNA biogenesis and processing pathway. AGO2 gene may have an onco-miR or tumor suppressor-miR role in tumor genesis.
vahid ayani, saeid ghorbian, MB Abolghasem Fakhri   +2 more
doaj  

Polymorphisms and expression of genes encoding Argonautes 1 and 2 in autoimmune thyroid diseases

Autoimmunity, 2018
The microRNA (miRNA) biogenesis pathway is regulated by specific proteins and enzymes, including Dicer, Drosha, DGCR8, Exportin 5 and the Argonaute (AGO) family.
Ena Tokiyoshi, Mikio Watanabe, Naoya Inoue, Yoh Hidaka, Yoshinori Iwatani   +4 more
doaj   +1 more source

Argonaute 2 Expression Correlates with a Luminal B Breast Cancer Subtype and Induces Estrogen Receptor Alpha Isoform Variation

Non-Coding RNA, 2016
Estrogen receptor alpha (ERα) signaling pathways are frequently disrupted in breast cancer and contribute to disease progression. ERα signaling is multifaceted and many ERα regulators have been identified including transcription factors and growth factor
Adrienne K. Conger, Elizabeth C. Martin, Thomas J. Yan, Lyndsay V. Rhodes, Van T. Hoang, Jacqueline La, Muralidharan Anbalagan, Hope E. Burks, Brian G. Rowan, Kenneth P. Nephew, Bridgette M. Collins-Burow, Matthew E. Burow   +11 more
doaj   +1 more source

Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells [PDF]

, 2021
Hailong Zhang, Xian Zhao, Yanmin Guo, Ran Chen, Jianfeng He, Lian Li, Zhe Qiang, Qianqian Yang, Xiaojia Liu, Caihu Huang, Runhui Lu, Jiayu Fang, Yingting Cao, Jiayi Huang, Yanli Wang, Jian Huang, Guoqiang Chen, Jinke Cheng, Jianxiu Yu   +18 more
openalex   +1 more source

MOV10 and FMRP Regulate AGO2 Association with MicroRNA Recognition Elements

Cell Reports, 2014
The fragile X mental retardation protein FMRP regulates translation of its bound mRNAs through incompletely defined mechanisms. FMRP has been linked to the microRNA pathway, and we show here that it associates with the RNA helicase MOV10, also associated with the microRNA pathway.
Kenny, Phillip J, Zhou, Hongjun, Kim, Miri, Skariah, Geena, Khetani, Radhika S, Drnevich, Jenny, Arcila, Mary Luz, Kosik, Kenneth S, Ceman, Stephanie   +8 more
openaire   +5 more sources