Results 121 to 130 of about 19,284 (137)

Differential RNAi efficacy of siRNA and dsRNA targeting key genes for pest control in <i>Spodoptera litura</i>. [PDF]

Front Insect Sci
Lin YC, Lu YH, Liu Y, Su YJ, Lin YH, Wu YL.   +5 more
europepmc   +1 more source

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Up-regulation of Ago2 expression in gastric carcinoma

Medical Oncology, 2013
Argonaute (Ago) proteins have been demonstrated to be widely expressed and involved in post-transcriptional gene silencing and thus play key roles in carcinogenesis. Nevertheless, little is known about the specific role of Ago2 in gastric cancer (GC).
Xiao-jun Zhou, Cai-Xia Wang, Xiangshan Fan, Biao Liu, Qin Li, Jin Zhang   +5 more
openaire   +3 more sources

Mapping of Ago2–GW182 Functional Interactions

2011
MicroRNA (miRNA)-mediated posttranscriptional regulation of gene expression has become a major focus in understanding fine-tuning controls in many biological processes. Argonaute 2 protein (Ago2), a core component of RNA-induced silencing complex, directly binds miRNA and functions in both RNAi and miRNA pathways. GW182 is a marker protein of GW bodies
Songqing Li, Edward K. L. Chan, Bing Yao, Marvin J. Fritzler, Shang Li Lian   +4 more
openaire   +3 more sources

Involvement of AGO1 and AGO2 in mammalian transcriptional silencing

Nature Structural & Molecular Biology, 2006
Duplex RNAs complementary to messenger RNA inhibit translation in mammalian cells by RNA interference (RNAi). Studies have reported that RNAs complementary to promoter DNA also inhibit gene expression. Here we show that the human homologs of Argonaute-1 (AGO1) and Argonaute-2 (AGO2) link the silencing pathways that target mRNA with pathways mediating ...
Rosalyn Ram, David R. Corey, Jacob C. Schwartz, Kenneth E. Huffman, Bethany A. Janowski, Robert Nordsell, John D. Minna, David S. Shames   +7 more
openaire   +3 more sources

Bio-functional surfaces for the immunocapture of AGO2-bound microRNAs

Colloids and Surfaces B: Biointerfaces, 2016
MicroRNAs (miRNAs) are endogenous, small (18-24nt), non-coding RNAs that regulate gene expression. Among miRNAs, those bound to the AGO2 protein are the functionally active fraction which mediates the cell regulatory processes and regulate messages exchanged by cells.
Vaghi V, Potrich C, Lunelli L, Facci P, Pasquardini L, Vanzetti L, Pederzolli C   +6 more
openaire   +6 more sources

AGO2 silences mobile transposons in the nucleus of quiescent cells

Nature Structural & Molecular Biology, 2023
Argonaute 2 (AGO2) is a cytoplasmic component of the miRNA pathway, with essential roles in development and disease. Yet little is known about its regulation in vivo. Here we show that in quiescent mouse splenocytes, AGO2 localizes almost exclusively to the nucleus.
Laura Sala, Manish Kumar, Mahendra Prajapat, Srividya Chandrasekhar, Rachel L. Cosby, Gaspare La Rocca, Todd S. Macfarlan, Parirokh Awasthi, Raj Chari, Michael Kruhlak, Joana A. Vidigal   +10 more
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Probing the nanoparticle–AGO2 interaction for enhanced gene knockdown

Soft Matter, 2018
RNA interference is a promising technology for treatment of various diseases. Here, we systematically probe the effect of steric hindrance of nanoparticles on the RNA induced silencing complex (RISC) interaction, by modulating two parameters, the nanoparticle size and hardness.
Sonal Deshpande, Neetu Singh, Neetu Singh   +2 more
openaire   +3 more sources