Results 11 to 20 of about 19,284 (137)

The Expression of AGO2 and DGCR8 in Idiopathic Sudden Sensorineural Hearing Loss [PDF]

Clinical and Experimental Otorhinolaryngology, 2014
ObjectivesThe microRNAs have been implicated in the development and function of the inner ear, especially in contribution to hearing. However, the impact of idiopathic sudden sensorineural hearing loss (SSNHL) on expression of miRNA biogenesis-related ...
Soon Yong Han, Shin Kim, Dong-Hoon Shin, Jae Hyun Cho, Sung-Il Nam   +4 more
doaj   +5 more sources

SFTSV NSs interacts with AGO2 to regulate the RNAi pathway for viral replication [PDF]

Journal of Virology
RNA interference (RNAi) is a posttranscriptional gene silencing mechanism acting as an antiviral defense in eukaryotes. During viral replication, intermediate double-stranded RNAs are processed into virus-derived small interfering RNAs (vsiRNAs) by the ...
Nasir Javaid, Tae-Won Jang, Yuting Fu, Younho Choi   +3 more
doaj   +2 more sources

Retinal Degeneration Caused by Ago2 Disruption

Investigative Opthalmology & Visual Science, 2021
Argonaute proteins are key players in small RNA-guided gene silencing processes. Ago2 is the member of the Argonaute subfamily with slicer endonuclease activity and is critical for microRNA homeostasis and indispensable for biological development. However, the impact of Ago2 dysregulation in the retina remains to be fully explored.
Ya-Han Wang, Ya-Han Wang, Chang-Jun Zhang, Xue-Jiao Chen, Zi-Bing Jin, Zi-Bing Jin   +5 more
openaire   +2 more sources

An Antiviral Defense Role of AGO2 in Plants [PDF]

PLoS ONE, 2011
Argonaute (AGO) proteins bind to small-interfering (si)RNAs and micro (mi)RNAs to target RNA silencing against viruses, transgenes and in regulation of mRNAs. Plants encode multiple AGO proteins but, in Arabidopsis, only AGO1 is known to have an antiviral role.To uncover the roles of specific AGOs in limiting virus accumulation we inoculated turnip ...
Harvey, Jagger J.W., Lewsey, M.G., Patel, K., Westwood, J., Heimsta, S., Carr, J.P., Baulcombe, D.C.   +6 more
openaire   +5 more sources

Potential Ago2/miR-3068-5p Cascades in the Nucleus Accumbens Contribute to Methamphetamine-Induced Locomotor Sensitization of Mice

Frontiers in Pharmacology, 2021
Dysregulation of microRNA (miRNA) biogenesis is involved in drug addiction. Argonaute2 (Ago2), a specific splicing protein involved in the generation of miRNA, was found to be dysregulated in the nucleus accumbens (NAc) of methamphetamine (METH ...
Dan Liu, Dan Liu, Dan Liu, Min Liang, Min Liang, Li Zhu, Li Zhu, Ting-ting Zhou, Ting-ting Zhou, Yu Wang, Yu Wang, Rui Wang, Rui Wang, Fei-fei Wu, Fei-fei Wu, Eyleen L. K. Goh, Eyleen L. K. Goh, Teng Chen, Teng Chen   +18 more
doaj   +1 more source

New friends for Ago2 in neuronal plasticity [PDF]

The EMBO Journal, 2015
MicroRNAs have emerged as central regulators of cellular homeostasis and increasing evidence suggests that they play a key role in neuronal plasticity. Major efforts are made to define microRNA networks and their targets in the brain. The mechanisms by which microRNA activity is regulated are, however, relatively unexplored.
Sananbenesi, Farahnaz, Fischer, Andre
openaire   +5 more sources

Accumulation of AGO2 Facilitates Tumorigenesis of Human Hepatocellular Carcinoma [PDF]

BioMed Research International, 2020
AGO2 (Argonaute RISC Catalytic Component 2) plays an important role in small RNA‐guided gene silencing processes. It has been implied in tumorigenesis of different types of tumors. In this study, we found that AGO2 expression was remarkably increased in human hepatocellular carcinoma (HCC) tissues when compared with adjacent noncancerous tissues.
Yang Yang, Qi Mei
openaire   +2 more sources

Integrated miRNAome and Transcriptome Analysis Reveals Argonaute 2-Mediated Defense Responses Against the Devastating Phytopathogen Sclerotinia sclerotiorum

Frontiers in Plant Science, 2020
Argonaute 2 (AGO2)-mediated role in plant defense against fungal pathogens remains largely unknown. In this study, integrated miRNAome and transcriptome analysis employing ago2 mutant was performed to reveal AGO2-associated miRNAs and defense responses ...
Jia-Yi Cao, Jia-Yi Cao, You-Ping Xu, Xin-Zhong Cai   +3 more
doaj   +1 more source

Actin-dependent recruitment of AGO2 to the zonula adherens

Molecular Biology of the Cell, 2022
Adherens junctions are cadherin-based structures critical for cellular architecture. E-cadherin junctions in mature epithelial cell monolayers tether to an apical actomyosin ring to form the zonula adherens (ZA). We have previously shown that the adherens junction protein PLEKHA7 associates with and regulates the function of the core RNA interference (
Mary Catherine Bridges, Joyce Nair-Menon, Alyssa Risner, Douglas W. Jimenez, Amanda C. Daulagala, Christina Kingsley, Madison E. Davis, Antonis Kourtidis   +7 more
openaire   +2 more sources

Argonaute-2 protects the neurovascular unit from damage caused by systemic inflammation

Journal of Neuroinflammation, 2022
Background The brain vasculature plays a pivotal role in the inflammatory process by modulating the interaction between blood cells and the neurovascular unit.
Marta Machado-Pereira, Cláudia Saraiva, Liliana Bernardino, Ana C. Cristóvão, Raquel Ferreira   +4 more
doaj   +1 more source