KRAS Engages AGO2 to Enhance Cellular Transformation [PDF]
Cell Reports, 2016 Oncogenic mutations in RAS provide a compelling yet intractable therapeutic target. Using co-immunoprecipitation mass spectrometry, we uncovered an interaction between RAS and Argonaute 2 (AGO2).
Sunita Shankar +16 more
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PSMC3 promotes RNAi by maintaining AGO2 stability through USP14
Cellular & Molecular Biology Letters, 2022 Background Argonaute 2 (AGO2), the only protein with catalytic activity in the human Argonaute family, is considered as a key component of RNA interference (RNAi) pathway.
Yan Jia +7 more
doaj +3 more sources
KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes [PDF]
Cell Reports, 2016 Secretion of RNAs in extracellular vesicles is a newly recognized form of intercellular communication. A potential regulatory protein for microRNA (miRNA) secretion is the critical RNA-induced silencing complex (RISC) component Argonaute 2 (Ago2).
Andrew J. McKenzie +7 more
doaj +3 more sources
AGO2 phosphorylation by c-Src kinase promotes tumorigenesis
Neoplasia: An International Journal for Oncology Research, 2020 Numerous studies have reported that c-Src is highly expressed with high tyrosine kinase activity in a variety of tumors. However, it remains unclear whether c-Src contributes to the miRNA pathway.
Tianqi Liu +9 more
doaj +3 more sources
AGO1 and AGO2 act redundantly in miR408-mediated Plantacyanin regulation. [PDF]
PLoS ONE, 2011 BackgroundIn Arabidopsis, AGO1 and AGO2 associate with small RNAs that exhibit a Uridine and an Adenosine at their 5' end, respectively. Because most plant miRNAs have a 5'U, AGO1 plays many essential roles in miRNA-mediated regulation of development and
Nicolas Maunoury, Hervé Vaucheret
doaj +7 more sources
Actin-dependent recruitment of AGO2 to the zonula adherens [PDF]
Molecular Biology of the Cell, 2022 Adherens junctions are cadherin-based structures critical for cellular architecture. E-cadherin junctions in mature epithelial cell monolayers tether to an apical actomyosin ring to form the zonula adherens (ZA). We have previously shown that the adherens junction protein PLEKHA7 associates with and regulates the function of the core RNA interference ...
Catherine Bridges +7 more
openalex +3 more sources
Dysregulation of AGO2-miRNA dynamics underlies the AGO2-associated Lessel-Kreienkamp syndrome. [PDF]
Nucleic Acids ResAbstract Mutations in human Argonaute genes, AGO1 and AGO2, are associated with neurodevelopmental disorders. Although multiple patients have been identified, the underlying molecular basis for pathogenesis remains unclear. Here, we biochemically examined five AGO2 mutations (p.L192P, p.A367P, p.T357M, p.F182del, and p.G733R) linked to ...
Liu TM +8 more
europepmc +3 more sources
Accumulation of AGO2 Facilitates Tumorigenesis of Human Hepatocellular Carcinoma [PDF]
BioMed Research International, 2020 AGO2 (Argonaute RISC Catalytic Component 2) plays an important role in small RNA‐guided gene silencing processes. It has been implied in tumorigenesis of different types of tumors. In this study, we found that AGO2 expression was remarkably increased in human hepatocellular carcinoma (HCC) tissues when compared with adjacent noncancerous tissues.
Yang Yang, Qi Mei
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Retinal Degeneration Caused by Ago2 Disruption
Investigative Opthalmology & Visual Science, 2021 Argonaute proteins are key players in small RNA-guided gene silencing processes. Ago2 is the member of the Argonaute subfamily with slicer endonuclease activity and is critical for microRNA homeostasis and indispensable for biological development. However, the impact of Ago2 dysregulation in the retina remains to be fully explored.
Chen, Xue-Jiao +3 more
openaire +2 more sources
Centrosome‑, mitotic spindle‑ and cytokinetic bridge‑specific compartmentalization of AGO2 protein in human liver cells undergoing mitosis: Non‑canonical, RNAi‑dependent, control of local homeostasis. [PDF]
Mol Med RepTheotoki EI +7 more
europepmc +3 more sources