SFTSV NSs interacts with AGO2 to regulate the RNAi pathway for viral replication. [PDF]
J VirolJavaid N, Jang T-W, Fu Y, Choi Y.
europepmc +1 more source
Targeting microRNA-143 in colorectal cancer: advances in molecular biosciences for biomarker-based diagnostics, therapeutic strategies, and drug resistance prediction. [PDF]
Front Mol BiosciWang X, Wang L, Ke L.
europepmc +1 more source
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Mapping of Ago2–GW182 Functional Interactions
2011MicroRNA (miRNA)-mediated posttranscriptional regulation of gene expression has become a major focus in understanding fine-tuning controls in many biological processes. Argonaute 2 protein (Ago2), a core component of RNA-induced silencing complex, directly binds miRNA and functions in both RNAi and miRNA pathways. GW182 is a marker protein of GW bodies
Bing, Yao +4 more
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Up-regulation of Ago2 expression in gastric carcinoma
Medical Oncology, 2013Argonaute (Ago) proteins have been demonstrated to be widely expressed and involved in post-transcriptional gene silencing and thus play key roles in carcinogenesis. Nevertheless, little is known about the specific role of Ago2 in gastric cancer (GC).
Jin, Zhang +5 more
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Probing the nanoparticle–AGO2 interaction for enhanced gene knockdown
Soft Matter, 2018RNA interference is a promising technology for treatment of various diseases. Here, we systematically probe the effect of steric hindrance of nanoparticles on the RNA induced silencing complex (RISC) interaction, by modulating two parameters, the nanoparticle size and hardness.
Sonal Deshpande, Neetu Singh
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Involvement of AGO1 and AGO2 in mammalian transcriptional silencing
Nature Structural & Molecular Biology, 2006Duplex RNAs complementary to messenger RNA inhibit translation in mammalian cells by RNA interference (RNAi). Studies have reported that RNAs complementary to promoter DNA also inhibit gene expression. Here we show that the human homologs of Argonaute-1 (AGO1) and Argonaute-2 (AGO2) link the silencing pathways that target mRNA with pathways mediating ...
Bethany A, Janowski +7 more
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Bio-functional surfaces for the immunocapture of AGO2-bound microRNAs
Colloids and Surfaces B: Biointerfaces, 2016MicroRNAs (miRNAs) are endogenous, small (18-24nt), non-coding RNAs that regulate gene expression. Among miRNAs, those bound to the AGO2 protein are the functionally active fraction which mediates the cell regulatory processes and regulate messages exchanged by cells.
Vaghi V +6 more
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MicroRNA Northern Blotting, Precursor Cloning, and Ago2-Improved RNA Interference
2010Aberrant expression of microRNAs (miRNAs) and processing defects in their biogenesis pathway are a widespread phenomenon in tumors, conveying great importance to the analysis of miRNA expression, regulation, and biogenesis to gain knowledge about their role in cancer. Besides Drosha and Dicer, Argonaute proteins are key players in miRNA processing.
Julia, Winter, Sven, Diederichs
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Identifying RISC Components Using Ago2 Immunoprecipitation and Mass Spectrometry
2017Complex immunoprecipitation (Co-IP) is a powerful technique for precipitating an intact protein complex out of solution and cell lysates using an antibody that specifically binds to a particular protein in a large complex of proteins. Mass spectrometry (MS) is used to identify, sequence, and quantify proteins.
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AGO2 Protects Against Diabetic Cardiomyopathy by Activating Mitochondrial Gene Translation
CirculationBACKGROUND: Diabetes is associated with cardiovascular complications. microRNAs translocate into subcellular organelles to modify genes involved in diabetic cardiomyopathy. However, functional properties of subcellular AGO2 (Argonaute2), a core member of miRNA machinery, remain elusive. METHODS:
Jiabing Zhan +7 more
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