Results 21 to 30 of about 20,279 (201)
New friends for Ago2 in neuronal plasticity [PDF]
The EMBO Journal, 2015 MicroRNAs have emerged as central regulators of cellular homeostasis and increasing evidence suggests that they play a key role in neuronal plasticity. Major efforts are made to define microRNA networks and their targets in the brain. The mechanisms by which microRNA activity is regulated are, however, relatively unexplored.
Sananbenesi, Farahnaz, Fischer, Andre
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Biochemical characterization of the interaction between KRAS and Argonaute 2
Biochemistry and Biophysics Reports, 2022 Oncogenic mutations in KRAS result in a constitutively active, GTP-bound form that in turn activates many proliferative pathways. However, because of its compact and simple architecture, directly targeting KRAS with small molecule drugs has been ...
Jessica J. Waninger +8 more
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AGO2: A New Argonaute Compromising Plant Virus Accumulation [PDF]
Frontiers in Plant Science, 2012 Plant viruses use several strategies to transport their nucleic acid genomes throughout the plants. Regardless of the movement mechanism, a universal major block to uninterrupted viral trafficking is the induction of antiviral silencing that degrades viral RNA.
Alvarado, Veria Y., Scholthof, Herman B.
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p63, a key regulator of Ago2, links to the microRNA-144 cluster
Cell Death and Disease, 2022 As a key component of the RNA-induced silencing complex (RISC), Argonaute2 (Ago2) exhibits a dual function regulatory role in tumor progression. However, the mechanistic basis of differential regulation remains elusive.
Benfan Wang +7 more
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Dicer-independent, Ago2-mediated microRNA biogenesis in vertebrates [PDF]
Cell Cycle, 2010 A canonical biogenesis pathway involving sequential cleavage by the Drosha and Dicer RNAse III enzymes governs the maturation of most animal microRNAs. However, there exist a variety of alternative miRNA biogenesis pathways, most of which bypass Drosha processing.
Jr-Shiuan, Yang, Eric C, Lai
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Analysis of chimeric reads characterises the diverse targetome of AGO2-mediated regulation
Scientific Reports, 2023 Argonaute proteins are instrumental in regulating RNA stability and translation. AGO2, the major mammalian Argonaute protein, is known to primarily associate with microRNAs, a family of small RNA ‘guide’ sequences, and identifies its targets primarily ...
Vaclav Hejret +6 more
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Antineovascular Gene Therapy by Ago2 Knockdown
YAKUGAKU ZASSHI, 2008 Small interfering RNA (siRNA), which induces sequence-dependent gene silencing, has been widely studied. We previously developed polycation liposomes (PCL) as carriers of plasmid DNA and succeeded in showing their potent gene expression efficiency.
Kentaro, Hatanaka +3 more
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Sumoylation of human argonaute 2 at lysine-402 regulates its stability. [PDF]
PLoS ONE, 2014 Gene silencing by small RNAs has emerged as a powerful post-transcriptional regulator of gene expression, however processes underlying regulation of the small RNA pathway in vivo are still largely elusive.
Umut Sahin +4 more
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Argonaute2 suppresses Drosophila fragile X expression preventing neurogenesis and oogenesis defects. [PDF]
PLoS ONE, 2009 Fragile X Syndrome is caused by the silencing of the Fragile X Mental Retardation gene (FMR1). Regulating dosage of FMR1 levels is critical for proper development and function of the nervous system and germ line, but the pathways responsible for ...
Anita S-R Pepper +3 more
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DICER-ARGONAUTE2 complex in continuous fluorogenic assays of RNA interference enzymes. [PDF]
PLoS ONE, 2015 Mechanistic studies of RNA processing in the RNA-Induced Silencing Complex (RISC) have been hindered by lack of methods for continuous monitoring of enzymatic activity. "Quencherless" fluorogenic substrates of RNAi enzymes enable continuous monitoring of
Mark A Bernard +2 more
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