Results 31 to 40 of about 19,284 (137)
Life beyond cleavage: the case of Ago2 and hematopoiesis [PDF]
Genes & Development, 2007 A recent article in The Economist (June 16, 2007) describes research on RNA as the 21st century’s Big Bang in biology. The “stars” of the RNA universe are small regulatory RNAs known as microRNAs (miRNAs). These ∼22-nt-long RNAs were discovered in 1993 (Lee et al. 1993; Wightman et al.
Meinrad Busslinger, Javier Martinez
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AGO2: A New Argonaute Compromising Plant Virus Accumulation [PDF]
Frontiers in Plant Science, 2012 Plant viruses use several strategies to transport their nucleic acid genomes throughout the plants. Regardless of the movement mechanism, a universal major block to uninterrupted viral trafficking is the induction of antiviral silencing that degrades viral RNA.
Herman B. Scholthof, Veria Y. Alvarado
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RNAi and retroviruses: are they in RISC?
Biomolecular Concepts, 2013 RNA interference (RNAi) is a potent cellular system against viruses in various organisms. Although common traits are observed in plants, insects, and nematodes, the situation observed in mammals appears more complex.
Vasselon Thierry +3 more
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Impaired AGO2/miR-185-3p/NRP1 axis promotes colorectal cancer metastasis
Cell Death and Disease, 2021 Increasing evidence suggests that global downregulation of miRNA expression is a hallmark of human cancer, potentially due to defects in the miRNA processing machinery.
Xisheng Liu +12 more
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Nuclear Translocation of Argonaute 2 in Cytokine-Induced Senescence
Cellular Physiology and Biochemistry, 2018 Background/Aims: Cellular senescence, or permanent growth arrest, is known as an effective tumor suppressor mechanism that can be induced by different stressors, such as oncogenes, chemotherapeutics or cytokine cocktails.
Maximilian Rentschler +8 more
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Antineovascular Gene Therapy by Ago2 Knockdown
YAKUGAKU ZASSHI, 2008 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Kentaro Hatanaka +3 more
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Dicer-independent, Ago2-mediated microRNA biogenesis in vertebrates [PDF]
Cell Cycle, 2010 A canonical biogenesis pathway involving sequential cleavage by the Drosha and Dicer RNAse III enzymes governs the maturation of most animal microRNAs. However, there exist a variety of alternative miRNA biogenesis pathways, most of which bypass Drosha processing.
Jr-Shiuan Yang, Eric C. Lai
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Argonaute 2 Is Required for Extra-embryonic Endoderm Differentiation of Mouse Embryonic Stem Cells
Stem Cell Reports, 2018 Summary: In mouse, although four Argonaute (AGO) proteins with partly overlapping functions in small-RNA pathways exist, only Ago2 deficiency causes embryonic lethality.
Richard Patryk Ngondo +10 more
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Wellcome Open Research, 2020 Background: Plasmodium parasites rely on various host factors to grow and replicate within red blood cells (RBC). While many host proteins are known that mediate parasite adhesion and invasion, few examples of host enzymes co-opted by the parasite during
Franziska Hentzschel +2 more
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Scientific Reports, 2022 miRNAs are necessary for neuromuscular junction (NMJ) health; however, little is known about the proteins required for their activity in this regard.
Dillon Shapiro +3 more
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