Results 31 to 40 of about 20,279 (201)
Plants, 2021 RNA silencing is a sequence specific post-transcriptional mechanism regulating important biological processes including antiviral defense in plants. Argonaute (AGO) proteins, the catalytic subunits of the silencing complexes, are loaded with small RNAs ...
Erzsébet Kenesi +4 more
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RNAi and retroviruses: are they in RISC?
Biomolecular Concepts, 2013 RNA interference (RNAi) is a potent cellular system against viruses in various organisms. Although common traits are observed in plants, insects, and nematodes, the situation observed in mammals appears more complex.
Vasselon Thierry +3 more
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Impaired AGO2/miR-185-3p/NRP1 axis promotes colorectal cancer metastasis
Cell Death and Disease, 2021 Increasing evidence suggests that global downregulation of miRNA expression is a hallmark of human cancer, potentially due to defects in the miRNA processing machinery.
Xisheng Liu +12 more
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Activation of Gαq sequesters specific transcripts into Ago2 particles
Scientific Reports, 2022 AbstractThe Gαq/phospholipase Cβ1 (PLCβ1) signaling system mediates calcium responses from hormones and neurotransmitters. While PLCβ1 functions on the plasma membrane, there is an atypical cytosolic population that binds Argonaute 2 (Ago2) and other proteins associated with stress granules preventing their aggregation.
Lela Jackson +3 more
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AGO2 Mediates MYC mRNA Stability in Hepatocellular Carcinoma [PDF]
Molecular Cancer Research, 2020 Abstract Deregulated RNA-binding proteins (RBP), such as Argonaute 2 (AGO2), mediate tumor-promoting transcriptomic changes during carcinogenesis, including hepatocellular carcinoma (HCC). While AGO2 is well characterized as a member of the RNA-induced silencing complex (RISC), which represses
Kai Zhang +12 more
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Nuclear Translocation of Argonaute 2 in Cytokine-Induced Senescence
Cellular Physiology and Biochemistry, 2018 Background/Aims: Cellular senescence, or permanent growth arrest, is known as an effective tumor suppressor mechanism that can be induced by different stressors, such as oncogenes, chemotherapeutics or cytokine cocktails.
Maximilian Rentschler +8 more
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Stilbene derivatives promote Ago2-dependent tumour-suppressive microRNA activity [PDF]
Scientific Reports, 2012 It is well known that natural products are a rich source of compounds for applications in medicine, pharmacy, and biology. However, the exact molecular mechanisms of natural agents in human health have not been clearly defined. Here, we demonstrate for the first time that the polyphenolic phytoalexin resveratrol promotes expression and activity of ...
Hagiwara, Keitaro +5 more
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Argonaute 2 Is Required for Extra-embryonic Endoderm Differentiation of Mouse Embryonic Stem Cells
Stem Cell Reports, 2018 Summary: In mouse, although four Argonaute (AGO) proteins with partly overlapping functions in small-RNA pathways exist, only Ago2 deficiency causes embryonic lethality.
Richard Patryk Ngondo +10 more
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Wellcome Open Research, 2020 Background: Plasmodium parasites rely on various host factors to grow and replicate within red blood cells (RBC). While many host proteins are known that mediate parasite adhesion and invasion, few examples of host enzymes co-opted by the parasite during
Franziska Hentzschel +2 more
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Scientific Reports, 2022 miRNAs are necessary for neuromuscular junction (NMJ) health; however, little is known about the proteins required for their activity in this regard.
Dillon Shapiro +3 more
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