Results 41 to 50 of about 19,284 (137)

Strong reduction of AGO2 expression in melanoma and cellular consequences [PDF]

British Journal of Cancer, 2013
Processing of microRNAs (miRNAs) is a highly controlled process. Deregulation of miRNA expression was observed in several types of cancer but changes in the miRNA-processing enzymes have not been analysed until today. In this study, we analysed Argonaute2 (AGO2, EIF2C2), as one main factor of the miRNA processing ensemble, in the context of cancer ...
Gunter Meister, Daniel Völler, Jörg Reinders, Anja-Katrin Bosserhoff   +3 more
openaire   +3 more sources

An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development

Nature Communications, 2020
Argonaute 2 (AGO2) binds RAS and is required for cellular transformation. Here, the authors establish a KRAS-driven mouse model of pancreatic cancer with conditional loss of AGO2 and show that the early phase of neoplastic lesion initiation is dependent ...
Sunita Shankar, Jean Ching-Yi Tien, Ronald F. Siebenaler, Seema Chugh, Vijaya L. Dommeti, Sylvia Zelenka-Wang, Xiao-Ming Wang, Ingrid J. Apel, Jessica Waninger, Sanjana Eyunni, Alice Xu, Malay Mody, Andrew Goodrum, Yuping Zhang, John J. Tesmer, Rahul Mannan, Xuhong Cao, Pankaj Vats, Sethuramasundaram Pitchiaya, Stephanie J. Ellison, Jiaqi Shi, Chandan Kumar-Sinha, Howard C. Crawford, Arul M. Chinnaiyan   +23 more
doaj   +1 more source

MicroRNA regulator gene mutations in thyroid follicular nodular disease and thyroid cancer: does it all come down to timing?

European Thyroid Journal
In recent years, germline mutations in the microRNA (miRNA) processor genes DICER1 and DGCR8 have been coupled to the development of thyroid follicular nodular disease (TFND), thereby casting new light on the etiology of this enigmatic, benign condition ...
Vincenzo Condello, C Christofer Juhlin
doaj   +1 more source

Identification of subcellular localization of Arabidopsis AGO2

浙江大学学报. 农业与生命科学版, 2013
Argonaute (AGO) protein is a highly-conserved family with many members, containing three conserved domains, PAZ, MID and PIWI. Arabidopsis AGO comprises 10 proteins named from AtAGO1 to AtAGO10, which are grouped into three classes with AtAGO1, AtAGO5 and AtAGO10; AtAGO2, AtAGO3 and AtAGO7; and AtAGO4, AtAGO6, AtAGO8 and AtAGO9 as one class ...
Cai Xin-zhong, Xia Wenqiang, Zhao Li
openaire   +3 more sources

Argonaute2 and LaminB modulate gene expression by controlling chromatin topology. [PDF]

PLoS Genetics, 2018
Drosophila Argonaute2 (AGO2) has been shown to regulate expression of certain loci in an RNA interference (RNAi)-independent manner, but its genome-wide function on chromatin remains unknown.
Ezequiel Nazer, Ryan K Dale, Madoka Chinen, Behram Radmanesh, Elissa P Lei   +4 more
doaj   +1 more source

Ago2/CAV1 interaction potentiates metastasis via controlling Ago2 localization and miRNA action

EMBO Reports
AbstractAgo2 differentially regulates oncogenic and tumor-suppressive miRNAs in cancer cells. This discrepancy suggests a secondary event regulating Ago2/miRNA action in a context-dependent manner. We show here that a positive charge of Ago2 K212, that is preserved by SIR2-mediated Ago2 deacetylation in cancer cells, is responsible for the direct ...
Meng-Chieh Lin, Wen-Hung Kuo, Shih-Yin Chen, Jing-Ya Hsu, Li-Yu Lu, Chen-Chi Wang, Yi-Ju Chen, Jia-Shiuan Tsai, Hua-Jung Li   +8 more
openaire   +2 more sources

Argonaute 2 in cell-secreted microvesicles guides the function of secreted miRNAs in recipient cells. [PDF]

PLoS ONE, 2014
MicroRNAs (miRNAs) secreted by cells into microvesicles (MVs) form a novel class of signal molecules that mediate intercellular communication. However, several fundamental aspects of secreted miRNAs remain unknown, particularly the mechanism that governs
Zhiyuan Lv, Yao Wei, Dong Wang, Chen-Yu Zhang, Ke Zen, Limin Li   +5 more
doaj   +1 more source

An Aedes aegypti-Derived Ago2 Knockout Cell Line to Investigate Arbovirus Infections

Viruses, 2021
Mosquitoes are known as important vectors of many arthropod-borne (arbo)viruses causing disease in humans. These include dengue (DENV) and Zika (ZIKV) viruses.
Christina Scherer, Jack Knowles, Vattipally B. Sreenu, Anthony C. Fredericks, Janina Fuss, Kevin Maringer, Ana Fernandez-Sesma, Andres Merits, Margus Varjak, Alain Kohl, Esther Schnettler   +10 more
doaj   +1 more source

Mechanistic insights on the Dicer-independent AGO2-mediated processing of AgoshRNAs [PDF]

RNA Biology, 2015
Short hairpin RNAs (shRNAs) are widely used for gene knockdown by inducing the RNA interference (RNAi) mechanism, both for research and therapeutic purposes. The shRNA precursor is processed by the RNase III-like enzyme Dicer into biologically active small interfering RNA (siRNA).
Ying Poi Liu, Elena Herrera-Carrillo, Alex Harwig, Aldo Jongejan, Antoine H. C. van Kampen, Margarete Karg, Ben Berkhout   +6 more
openaire   +3 more sources

Fam172a Mediates the Stimulation of Hypothalamic Oxytocin Neurons to Suppress Obesity‐Induced Anxiety

Advanced Science
Anxiety disorder is the most common mental disorder worldwide. Although human studies have demonstrated a positive association between obesity and anxiety disorder, the exact mechanism linking these conditions is unclear.
Baocheng Wan, Lina Zhang, Xinyu Wang, Rong Zhang, Lianxi Li, Yi Zhang, Zhuo Chen, Cheng Hu   +7 more
doaj   +1 more source