Results 41 to 50 of about 20,279 (201)

Antagonistic and cooperative AGO2-PUM interactions in regulating mRNAs [PDF]

Scientific Reports, 2018
AbstractApproximately 1500 RNA-binding proteins (RBPs) profoundly impact mammalian cellular function by controlling distinct sets of transcripts, often using sequence-specific binding to 3′ untranslated regions (UTRs) to regulate mRNA stability and translation. Aside from their individual effects, higher-order combinatorial interactions between RBPs on
Erin L. Sternburg, Jason A. Estep, Daniel K. Nguyen, Yahui Li, Fedor V. Karginov   +4 more
openaire   +4 more sources

An Antiviral Defense Role of AGO2 in Plants

PLoS ONE, 2011
Argonaute (AGO) proteins bind to small-interfering (si)RNAs and micro (mi)RNAs to target RNA silencing against viruses, transgenes and in regulation of mRNAs. Plants encode multiple AGO proteins but, in Arabidopsis, only AGO1 is known to have an antiviral role.To uncover the roles of specific AGOs in limiting virus accumulation we inoculated turnip ...
Harvey, Jagger J.W., Lewsey, M.G., Patel, K., Westwood, J., Heimsta, S., Carr, J.P., Baulcombe, D.C.   +6 more
openaire   +5 more sources

MicroRNA regulator gene mutations in thyroid follicular nodular disease and thyroid cancer: does it all come down to timing?

European Thyroid Journal
In recent years, germline mutations in the microRNA (miRNA) processor genes DICER1 and DGCR8 have been coupled to the development of thyroid follicular nodular disease (TFND), thereby casting new light on the etiology of this enigmatic, benign condition ...
Vincenzo Condello, C Christofer Juhlin
doaj   +1 more source

An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development

Nature Communications, 2020
Argonaute 2 (AGO2) binds RAS and is required for cellular transformation. Here, the authors establish a KRAS-driven mouse model of pancreatic cancer with conditional loss of AGO2 and show that the early phase of neoplastic lesion initiation is dependent ...
Sunita Shankar, Jean Ching-Yi Tien, Ronald F. Siebenaler, Seema Chugh, Vijaya L. Dommeti, Sylvia Zelenka-Wang, Xiao-Ming Wang, Ingrid J. Apel, Jessica Waninger, Sanjana Eyunni, Alice Xu, Malay Mody, Andrew Goodrum, Yuping Zhang, John J. Tesmer, Rahul Mannan, Xuhong Cao, Pankaj Vats, Sethuramasundaram Pitchiaya, Stephanie J. Ellison, Jiaqi Shi, Chandan Kumar-Sinha, Howard C. Crawford, Arul M. Chinnaiyan   +23 more
doaj   +1 more source

Ago2/CAV1 interaction potentiates metastasis via controlling Ago2 localization and miRNA action

EMBO Reports
AbstractAgo2 differentially regulates oncogenic and tumor-suppressive miRNAs in cancer cells. This discrepancy suggests a secondary event regulating Ago2/miRNA action in a context-dependent manner. We show here that a positive charge of Ago2 K212, that is preserved by SIR2-mediated Ago2 deacetylation in cancer cells, is responsible for the direct ...
Meng-Chieh Lin, Wen-Hung Kuo, Shih-Yin Chen, Jing-Ya Hsu, Li-Yu Lu, Chen-Chi Wang, Yi-Ju Chen, Jia-Shiuan Tsai, Hua-Jung Li   +8 more
openaire   +2 more sources

diRNA-Ago2-RAD51 complexes at double-strand break sites [PDF]

Cell Research, 2014
The way in which the DNA damage response signals the presence of DNA lesions and mediates DNA repair has not been fully elucidated. Now, Gao et al. reveal that diRNA-Ago2 complexes recruit RAD51 to the break sites.
Soichiro, Yamanaka, Haruhiko, Siomi
openaire   +2 more sources

Argonaute2 and LaminB modulate gene expression by controlling chromatin topology. [PDF]

PLoS Genetics, 2018
Drosophila Argonaute2 (AGO2) has been shown to regulate expression of certain loci in an RNA interference (RNAi)-independent manner, but its genome-wide function on chromatin remains unknown.
Ezequiel Nazer, Ryan K Dale, Madoka Chinen, Behram Radmanesh, Elissa P Lei   +4 more
doaj   +1 more source

Argonaute 2 in cell-secreted microvesicles guides the function of secreted miRNAs in recipient cells. [PDF]

PLoS ONE, 2014
MicroRNAs (miRNAs) secreted by cells into microvesicles (MVs) form a novel class of signal molecules that mediate intercellular communication. However, several fundamental aspects of secreted miRNAs remain unknown, particularly the mechanism that governs
Zhiyuan Lv, Yao Wei, Dong Wang, Chen-Yu Zhang, Ke Zen, Limin Li   +5 more
doaj   +1 more source

Dysregulation of CircZNF79(5) Modulates YBX1 Stability and Selective Autophagy to Drive Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
In HCC, circZNF79(5) binds to YBX1 and functions as an oncogene, recruits BRCC36 to remove K63‐linked ubiquitin chains to stabilize YBX1 protein, and promotes HCC progression via the HIF‐1 signaling pathway. Conversely, circZNF79(5) silencing activates the AMPK/mTOR pathway, inducing p62‐mediated selective autophagic degradation of YBX1.
Xueqiang Guo, Lingling Xi, Yukun Liu, Wenbao Lv, Tianzi Li, Andong Ju, Zhenlin Fan, Yaping Shen, Zhuang Qian, Weiyun Wang, Zhuo Liang, Wenjuan Song, Kaiwen Chang, Shuangping Ma, Junhe Zhang, Tao Han, Kun You, Cunshuan Xu, Lei Wang, Weisheng Guo, Wenjie Ren   +20 more
wiley   +1 more source

Analysis of AgoshRNA maturation and loading into Ago2

PLOS ONE, 2017
The RNA interference (RNAi) pathway was recently expanded by the discovery of multiple alternative pathways for processing of natural microRNA (miRNA) and man-made short hairpin RNA (shRNA) molecules. One non-canonical pathway bypasses Dicer cleavage and requires instead processing by Argonaute2 (Ago2), which also executes the subsequent silencing step.
Alex Harwig, Zita Kruize, Zhenhuang Yang, Tobias Restle, Ben Berkhout   +4 more
openaire   +5 more sources