Results 51 to 60 of about 19,284 (137)

AGO2 localizes to cytokinetic protrusions in a p38-dependent manner and is needed for accurate cell division

Communications Biology, 2021
Pantazopoulou et al. find that AGO2 resides in open-ended tunneling nanotubes and close-ended cytokinetic bridges. At the latter location, AGO2 colocalizes with cell division components and the authors show that AGO2 depletion impairs cell division ...
Vasiliki I. Pantazopoulou, Anastasios D. Delis, Stella Georgiou, Stamatis N. Pagakis, Vicky Filippa, Eleni Dragona, Ismini Kloukina, Elias Chatzitheodoridis, Jonel Trebicka, Athanassios D. Velentzas, Maja Thiele, Sarantis Gagos, Dimitris Thanos, Sofia Tseleni-Balafouta, Dimitrios J. Stravopodis, Ema Anastasiadou   +15 more
doaj   +1 more source

Selective autophagy degrades DICER and AGO2 and regulates miRNA activity [PDF]

Nature Cell Biology, 2012
MicroRNAs (miRNAs) form a class of short RNAs (∼ 21 nucleotides) that post-transcriptionally regulate partially complementary messenger RNAs. Each miRNA may target tens to hundreds of transcripts to control key biological processes. Although the biochemical reactions underpinning miRNA biogenesis and activity are relatively well defined and the ...
Florence Jay, Pascale Cossart, Pascale Cossart, Pascale Cossart, Derrick Gibbings, Serge Mostowy, Olivier Voinnet, Yannick Schwab   +7 more
openaire   +5 more sources

Control of hepatic gluconeogenesis by Argonaute2

Molecular Metabolism, 2018
Objective: The liver performs a central role in regulating energy homeostasis by increasing glucose output during fasting. Recent studies on Argonaute2 (Ago2), a key RNA-binding protein mediating the microRNA pathway, have illustrated its role in ...
Xin Yan, Zhen Wang, Christopher A. Bishop, Karolin Weitkunat, Xiao Feng, Marcel Tarbier, Jiankai Luo, Marc R. Friedländer, Ralph Burkhardt, Susanne Klaus, Thomas E. Willnow, Matthew N. Poy   +11 more
doaj   +1 more source

Silencing of HuR Inhibits Osteosarcoma Cell Epithelial-Mesenchymal Transition via AGO2 in Association With Long Non-Coding RNA XIST

Frontiers in Oncology, 2021
BackgroundOsteosarcoma (OS) is a highly malignant and aggressive bone tumor. This study was performed to explore the mechanisms of HuR (human antigen R) in the progression of OS.MethodsHuR expression levels in OS tissues and cells were detected by ...
Yongming Liu, Yuan Zhang, Jinxue Zhang, Jingchang Ma, Xuexue Xu, Yuling Wang, Ziqing Zhou, Dongxu Jiang, Shen Shen, Yong Ding, Yong Zhou, Ran Zhuang, Ran Zhuang   +12 more
doaj   +1 more source

Hepatitis B virus-specific miRNAs and Argonaute2 play a role in the viral life cycle. [PDF]

PLoS ONE, 2012
UNLABELLED:Disease-specific serum miRNA profiles may serve as biomarkers and might reveal potential new avenues for therapy. An HBV-specific serum miRNA profile associated with HBV surface antigen (HBsAg) particles has recently been reported, and AGO2 ...
C Nelson Hayes, Sakura Akamatsu, Masataka Tsuge, Daiki Miki, Rie Akiyama, Hiromi Abe, Hidenori Ochi, Nobuhiko Hiraga, Michio Imamura, Shoichi Takahashi, Hiroshi Aikata, Tomokazu Kawaoka, Yoshiiku Kawakami, Waka Ohishi, Kazuaki Chayama   +14 more
doaj   +1 more source

Comment on ‘Strong reduction of AGO2 expression in melanoma and cellular consequences’ [PDF]

British Journal of Cancer, 2014
Sir, We would like to congratulate Voller et al (2013) on their recent study showing an unchanged mRNA AGO2 expression in melanoma and a strong reduction of AGO2 expression on protein level. This goes along with the findings in our study on the miRNA processing machinery performed in melanoma, which likewise has previously shown an unchanged mRNA ...
Dimitrios Georgas, F.G. Bechara, Michael Sand, Schapoor Hessam   +3 more
openaire   +3 more sources

Essential role for Argonaute2 protein in mouse oogenesis

Epigenetics & Chromatin, 2009
Background Argonaute2 protein (Ago2) is a key component of RNA-induced gene silencing complex, which is crucial for microRNA-mediated repression of target genes.
Kaneda Masahiro, Tang Fuchou, O'Carroll Dónal, Lao Kaiqin, Surani M Azim   +4 more
doaj   +1 more source

Roquin-1 resolves sepsis-associated acute liver injury by regulating inflammatory profiles via miRNA cargo in extracellular vesicles

iScience, 2023
Summary: Sepsis-associated acute liver injury (SALI) is an independent risk for sepsis-induced death orchestrated by innate and adaptive immune responses.
Lei Zheng, Wei Ling, Deming Zhu, Zhi Li, Yousheng Li, Haoming Zhou, Lianbao Kong   +6 more
doaj   +1 more source

E-cadherin Interacts With Posttranslationally-Modified AGO2 to Enhance miRISC Activity

Frontiers in Cell and Developmental Biology, 2021
Graphical AbstractRegulatory effect between E-cadherin and AGO2.
Jie-Ning Li, Jie-Ning Li, Hui-Lung Sun, Ming-Yang Wang, Ming-Yang Wang, Pai-Sheng Chen, Pai-Sheng Chen   +6 more
openaire   +4 more sources

Deep Sequence Analysis of AgoshRNA Processing Reveals 3’ A Addition and Trimming

Molecular Therapy: Nucleic Acids, 2015
The RNA interference (RNAi) pathway, in which microprocessor and Dicer collaborate to process microRNAs (miRNA), was recently expanded by the description of alternative processing routes. In one of these noncanonical pathways, Dicer action is replaced by
Alex Harwig, Elena Herrera-Carrillo, Aldo Jongejan, Antonius Hubertus van Kampen, Ben Berkhout   +4 more
doaj   +1 more source