Results 61 to 70 of about 19,284 (137)

Argonaute 2 restored erectile function and corpus cavernosum mitochondrial function by reducing apoptosis in a mouse model of cavernous nerve injury [PDF]

Investigative and Clinical Urology
Purpose: To determine whether the overexpression of the Argonaute RNA-induced silencing complex catalytic component 2 (Ago2) improves erectile function in mice after cavernous nerve injury (CNI).
Yan Huang, Guo Nan Yin, Fang-Yuan Liu, Fitri Rahma Fridayana, Lashkari Niloofar, Minh Nhat Vo, Ji-Kan Ryu   +6 more
doaj   +1 more source

Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance. [PDF]

PLoS ONE, 2008
microRNAs (miRNAs) are small non-coding RNAs that regulate mRNA stability and translation through the action of the RNAi-induced silencing complex (RISC).
David G Hendrickson, Daniel J Hogan, Daniel Herschlag, James E Ferrell, Patrick O Brown   +4 more
doaj   +1 more source

Crispr/Cas9 Mediated Inactivation of Argonaute 2 Reveals its Differential Involvement in Antiviral Responses

Scientific Reports, 2017
RNA silencing constitutes an important antiviral mechanism in plants. Small RNA guided Argonaute proteins fulfill essential role in this process by acting as executors of viral restriction.
Márta Ludman, József Burgyán, Károly Fátyol   +2 more
doaj   +1 more source

Tryptophan As a New Member of RNA‐Induced Silencing Complexes Prevents Colon Cancer Liver Metastasis

Advanced Science
Essential amino acids (EAA) and microRNAs (miRs) control biological activity of a cell. Whether EAA regulates the activity of miR has never been demonstrated. Here, as proof‐of‐concept, a tryptophan (Trp, an EAA) complex containing Argonaute 2 (Ago2) and
Fangyi Xu, Yi Ren, Yun Teng, Jingyao Mu, Jie Tang, Kumaran Sundaram, Lifeng Zhang, Juw Won Park, Jae Yeon Hwang, Jun Yan, Gerald Dryden, Huang‐Ge Zhang   +11 more
doaj   +1 more source

Natural variation of the amino-terminal glutamine-rich domain in Drosophila argonaute2 is not associated with developmental defects.

PLoS ONE, 2010
The Drosophila argonaute2 (ago2) gene plays a major role in siRNA mediated RNA silencing pathways. Unlike mammalian Argonaute proteins, the Drosophila protein has an unusual amino-terminal domain made up largely of multiple copies of glutamine-rich ...
Daniel Hain, Brian R Bettencourt, Katsutomo Okamura, Tibor Csorba, Wibke Meyer, Zhigang Jin, Jason Biggerstaff, Haruhiko Siomi, Gyorgy Hutvagner, Eric C Lai, Michael Welte, H-Arno J Müller   +11 more
doaj   +1 more source

Evaluating the diagnostic value of Argonaute 2 gene expression changes in patients with colorectal cancer [PDF]

فصلنامه ابن سینا, 2018
Background: The protein encoded by argonaute 2 gene (AGO2) plays a critical role in micro-RNA biogenesis and processing pathway. AGO2 gene may have an onco-miR or tumor suppressor-miR role in tumor genesis.
vahid ayani, saeid ghorbian, MB Abolghasem Fakhri   +2 more
doaj  

Argonaute 2 Expression Correlates with a Luminal B Breast Cancer Subtype and Induces Estrogen Receptor Alpha Isoform Variation

Non-Coding RNA, 2016
Estrogen receptor alpha (ERα) signaling pathways are frequently disrupted in breast cancer and contribute to disease progression. ERα signaling is multifaceted and many ERα regulators have been identified including transcription factors and growth factor
Adrienne K. Conger, Elizabeth C. Martin, Thomas J. Yan, Lyndsay V. Rhodes, Van T. Hoang, Jacqueline La, Muralidharan Anbalagan, Hope E. Burks, Brian G. Rowan, Kenneth P. Nephew, Bridgette M. Collins-Burow, Matthew E. Burow   +11 more
doaj   +1 more source

Author Correction: Ago2/CAV1 interaction potentiates metastasis via controlling Ago2 localization and miRNA action

EMBO Reports
[Image: see text]
Meng-Chieh Lin, Wen-Hung Kuo, Shih-Yin Chen, Jing-Ya Hsu, Li-Yu Lu, Chen-Chi Wang, Yi-Ju Chen, Jia-Shiuan Tsai, Hua-Jung Li   +8 more
openaire   +1 more source

Polymorphisms and expression of genes encoding Argonautes 1 and 2 in autoimmune thyroid diseases

Autoimmunity, 2018
The microRNA (miRNA) biogenesis pathway is regulated by specific proteins and enzymes, including Dicer, Drosha, DGCR8, Exportin 5 and the Argonaute (AGO) family.
Ena Tokiyoshi, Mikio Watanabe, Naoya Inoue, Yoh Hidaka, Yoshinori Iwatani   +4 more
doaj   +1 more source

Design of antiviral AGO2-dependent short hairpin RNAs

Virologica Sinica
The increasing emergence and re-emergence of RNA virus outbreaks underlines the urgent need to develop effective antivirals. RNA interference (RNAi) is a sequence-specific gene silencing mechanism that is triggered by small interfering RNAs (siRNAs) or short hairpin RNAs (shRNAs), which exhibits significant promise for antiviral therapy. AGO2-dependent
Yuanyuan Bie, Jieling Zhang, Jiyao Chen, Yumin Zhang, Muhan Huang, Leike Zhang, Xi Zhou, Yang Qiu   +7 more
openaire   +2 more sources