Results 71 to 80 of about 19,284 (137)

IRF7 promotes glioma cell invasion by inhibiting AGO2 expression

Tumor Biology, 2015
Interferon regulatory factor 7 (IRF7) is the master transcription factor that plays a pivotal role in the transcriptional activation of type I interferon genes in the inflammatory response. Our previous study revealed that IRF7 is an important regulator of tumor progression via the expression of inflammatory cytokines in glioma.
Sung Chan Kim, Sunyoung Seo, Xiong Jin, Seon Yong Lee, Hyunggee Kim, Sung Hak Kim, Sung Hak Kim, Jun Kyum Kim, Seok Won Ham   +8 more
openaire   +3 more sources

MOV10 and FMRP Regulate AGO2 Association with MicroRNA Recognition Elements

Cell Reports, 2014
The fragile X mental retardation protein FMRP regulates translation of its bound mRNAs through incompletely defined mechanisms. FMRP has been linked to the microRNA pathway, and we show here that it associates with the RNA helicase MOV10, also associated with the microRNA pathway.
Kenny, Phillip J, Zhou, Hongjun, Kim, Miri, Skariah, Geena, Khetani, Radhika S, Drnevich, Jenny, Arcila, Mary Luz, Kosik, Kenneth S, Ceman, Stephanie   +8 more
openaire   +5 more sources

Comprehensive RNA dataset of AGO2 associated RNAs in Jurkat cells following miR-21 over-expression

Data in Brief, 2016
We set out to identify miR-21 targets in Jurkat cells using a high-throughput biochemical approach (10.1016/j.biochi.2014.09.021 [1]). Using a specific monoclonal antibody raised against AGO2, RISC complexes were immunopurified in Jurkat cells over ...
Claudia Carissimi, Teresa Colombo, Gianluca Azzalin, Emanuela Cipolletta, Ilaria Laudadio, Giuseppe Macino, Valerio Fulci   +6 more
doaj   +1 more source

Phosphorylation of AGO2 by TBK1 Promotes the Formation of Oncogenic miRISC in NSCLC

Advanced Science
AbstractNon‐small‐cell lung cancer (NSCLC) is a highly lethal tumor that often develops resistance to targeted therapy. It is shown that Tank‐binding kinase 1 (TBK1) phosphorylates AGO2 at S417 (pS417‐AGO2), which promotes NSCLC progression by increasing the formation of microRNA‐induced silencing complex (miRISC). High levels of pS417‐AGO2 in clinical
Xian Zhao, Yingting Cao, Runhui Lu, Zihan Zhou, Caihu Huang, Lian Li, Jiayi Huang, Ran Chen, Yanli Wang, Jian Huang, Jinke Cheng, Junke Zheng, Yujie Fu, Jianxiu Yu   +13 more
openaire   +3 more sources

Reactivity of human AGO2 monoclonal antibody 11A9 with the SWI/SNF complex: A case study for rigorously defining antibody selectivity

Scientific Reports, 2017
In this study, we originally aimed to characterize the potential role of Argonaute 2 (AGO2) in the nucleus, a key protein of the miRNA machinery. We combined Chromatin Immunoprecipitation (ChIP) with high throughput sequencing (ChIP-seq) and quantitative
Roderick A. P. M. van Eijl, Teun van den Brand, Luan N. Nguyen, Klaas W. Mulder   +3 more
doaj   +1 more source

Characterization of AGO2 complexes

, 2013
Abstract The AGO2 protein is part of a highly conserved family of RNA-binding protein called Argonaute. This protein family plays a key role in gene expression regulation in association with different classes of small non-coding RNA (miRNA, siRNA, piRNA). In addition to the post-transcriptional regulation in the cytoplasm, AGO2 protein acts also in the
openaire   +2 more sources

Ago2-Mediated Recruitment of HP1a on Transposable Elements in <i>Drosophila</i> Brain. [PDF]

Cells
Olenkina OM, Simonov RA, Ivannikova AY, Abramov YA, Sivkina AL, Ulianov SV, Shevelyov YY.   +6 more
europepmc   +1 more source

Argonaute 2 inhibits RIG-I signaling via competition for viral RNA binding. [PDF]

iScience
Liu H, Liao Y, Yu F, Li LN, Zhang Y, Zhu L, Xie G, Liu J, Liu S, Deng S, Tam RC, Song W, Chen P, Huang X, Cremin CJ, Chen Y, Zheng M, Wang P, Cai Z, Yuen KY, Chen H, Mok BW.   +21 more
europepmc   +1 more source

Partners in Silencing: Decoding the Mammalian Argonaute Interactome. [PDF]

Noncoding RNA
Narasimhan S, Erkeland SJ.
europepmc   +1 more source

Radiation Modifies Let-7 miRNA Binding to AGO2 Independent of Changes in Transcription to Influence Tumor Cell Radiosensitivity. [PDF]

Int J Mol Sci
Ali T, Degorre C, Tofilon PJ.
europepmc   +1 more source