Results 81 to 90 of about 20,279 (201)

Argonaute 2 restored erectile function and corpus cavernosum mitochondrial function by reducing apoptosis in a mouse model of cavernous nerve injury [PDF]

Investigative and Clinical Urology
Purpose: To determine whether the overexpression of the Argonaute RNA-induced silencing complex catalytic component 2 (Ago2) improves erectile function in mice after cavernous nerve injury (CNI).
Yan Huang, Guo Nan Yin, Fang-Yuan Liu, Fitri Rahma Fridayana, Lashkari Niloofar, Minh Nhat Vo, Ji-Kan Ryu   +6 more
doaj   +1 more source

MSC Membrane‐Coated circPROSC‐siRNA Nanoparticles for Ameliorating Craniosynostosis by Inhibiting Premature Suture Ossification

Advanced Science, Volume 13, Issue 3, 14 January 2026.
CircPROSC promotes craniosynostosis by sponging miR‐6815‐5p, thereby activating WNT3A/β‐catenin signaling and enhancing RUNX2‐mediated osteogenesis. Targeted silencing of circPROSC with MSC membrane–coated siRNA nanoparticles (MM@Lipo/si‐circPROSC) delivered postnatally into cranial sutures attenuates premature suture closure in Twist1+/– mice ...
Zhenkun Weng, Xiu Chen, Jin Xu, Qing Yan, Jian Jiao, Qian Liu, Aihua Gu   +6 more
wiley   +1 more source

Strong reduction of AGO2 expression in melanoma and cellular consequences [PDF]

British Journal of Cancer, 2013
Processing of microRNAs (miRNAs) is a highly controlled process. Deregulation of miRNA expression was observed in several types of cancer but changes in the miRNA-processing enzymes have not been analysed until today. In this study, we analysed Argonaute2 (AGO2, EIF2C2), as one main factor of the miRNA processing ensemble, in the context of cancer ...
Völler, D, Reinders, J, Meister, G, Bosserhoff, A-K   +3 more
openaire   +2 more sources

Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance. [PDF]

PLoS ONE, 2008
microRNAs (miRNAs) are small non-coding RNAs that regulate mRNA stability and translation through the action of the RNAi-induced silencing complex (RISC).
David G Hendrickson, Daniel J Hogan, Daniel Herschlag, James E Ferrell, Patrick O Brown   +4 more
doaj   +1 more source

Red Blood Cell‐Derived Exosomal miR‐93‐5p Promotes Lung Cancer Progression through PTEN Suppression

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Red blood cell (RBC)‐derived exosomal miR‐93‐5p is elevated in lung cancer patients and correlates with poor outcomes. Exosomal miR‐93‐5p suppresses PTEN in cancer cells, enhancing proliferation, migration, and invasion. In mouse models, therapeutic inhibition with ASO‐miR‐93 5p reduces tumor growth, highlighting a bidirectional tumor‐RBC‐tumor axis ...
Ning Li, Pushpa Dhilipkannah, Van K Holden, Ashutosh Sachdeva, Feng Jiang   +4 more
wiley   +1 more source

RNAi Regulator C3PO Promotes Arbovirus Infection in Insect Vectors

Advanced Science, Volume 13, Issue 4, 19 January 2026.
RNA interference (RNAi) is vital for eukaryotes to defend against virus infection. The C3PO complex takes part in RNAi but its role in regulating viral infection remains unclear. This work finds that insect C3PO facilitates arbovirus replication by degrading precursors of miRNAs, especially miR‐971‐3p.
Yan Xiao, Tianyu Guan, Qianfeng Xia, Chen Chen, Qian Wang, Lan Luo, Hong Lu, Feng Cui   +7 more
wiley   +1 more source

Crispr/Cas9 Mediated Inactivation of Argonaute 2 Reveals its Differential Involvement in Antiviral Responses

Scientific Reports, 2017
RNA silencing constitutes an important antiviral mechanism in plants. Small RNA guided Argonaute proteins fulfill essential role in this process by acting as executors of viral restriction.
Márta Ludman, József Burgyán, Károly Fátyol   +2 more
doaj   +1 more source

Treatment of breast cancer with autophagy inhibitory microRNAs carried by AGO2-conjugated nanoparticles [PDF]

, 2020
Özlem Ünal, Yunus Akkoç, Muhammed Koçak, Esra Nalbat, Işın Doğan Ekici, Havva Yağcı Acar, Devrim Gözüaçık   +6 more
openalex   +1 more source

Mechanistic Insights and Therapeutic Potential of Small Nucleolar RNA Host Genes in the Carcinogenesis of Hepatocellular Carcinoma

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Hepatocellular carcinoma (HCC) is one of the major factors endangering human health due to its poor prognosis, resulting from difficulties in early diagnosis and lack of effective treatment measures. Long non‐coding RNAs (lncRNAs), which are RNA molecules that do not translate into proteins, play essential roles in various tumor ...
Jiajia Luo, Zhangxiu Liao, Shuangxia Zhang   +2 more
wiley   +1 more source

Placental Extracellular Vesicles Exhibit Reduced Neurogenic Potential Linked to Changes in Their miRNA Landscape Upon HCMV Infection

Journal of Extracellular Biology, Volume 5, Issue 1, January 2026.
ABSTRACT Extracellular vesicles (EVs) are key mediators of maternal–foetal communication, regulating placental function and foetal development through the transfer of bioactive molecules. Although placental EVs play a crucial role in placental function during pregnancy, their contribution to foetal development, notably foetal brain, remains poorly ...
Charlène Martin, Hélène Martin, Mathilde Bergamelli, Lhorane Lobjois, Lucie Franco, Emma Bordes, Alexandra Benchoua, Stéphanie Balor, Diala Kantar, Etienne Coyaud, Frédéric Martins, Alexandre Favereaux, Cécile E. Malnou   +12 more
wiley   +1 more source