Results 101 to 110 of about 847,478 (341)

Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84 [PDF]

, 2017
Medium chain fatty acids can activate the pro-inflammatory receptor GPR84 but so also can molecules related to 3,3′-diindolylmethane. 3,3′-Diindolylmethane and decanoic acid acted as strong positive allosteric modulators of the function of each other and
De Vos, Steve, Gosmini, Romain, Hudson, Brian D., Jenkins, Laura, Labéguère, Frédéric, Mahmud, Zobaer Al, Milligan, Graeme, Tikhonova, Irina G., Ulven, Trond   +8 more
core   +3 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Structure-based analysis of the ultraspiracle protein and docking studies of putative ligands [PDF]

, 2002
The ultraspiracle protein (USP) is the insect ortholog of the mammalian retinoid X receptor (RXR). Fundamental questions concern the functional role of USP as the heterodimerization partner of insect nuclear receptors such as the ecdysone receptor.
Billas, Isabelle M.L., Iwema, Thomas, Moras, Dino, Sasorith, Souphatta, Wurtz, Jean-Marie   +4 more
core   +3 more sources

Towards High‐Acuity Vision Restoration: Hybrid Retinal Prosthesis Composed of a High‐Density Multielectrode Array Integrated With Glutamatergic Cells

Advanced Functional Materials, EarlyView.
This work introduces a novel Hybrid Retinal Implant (HRI), composed of a high‐density electrode array integrated with glutamatergic neurons to overcome key limitations of current retinal prostheses. The significant reduction of activation threshold and of electrode cross‐talk yields in an improved spatial resolution.
Nairouz Farah, Amos Markus, Gal Shpun, Yoav Chemla, Erel Lasnoy, Tamar Azrad‐Leibovitch, Fikre Fentahon, Zeev Zalvesky, Yossi Mandel   +8 more
wiley   +1 more source

Managing Opioid Addiction in Adolescents in the Community: Experiences from Two Cases

Journal of Mental Health and Human Behaviour
Introduction: Adolescent opioid use in India has emerged as a critical public health concern, with a 2018 survey revealing 1.8% of adolescents aged 10–17 years as past-year opioid users.
Manmeet Kaur Brar, Biswadip Chatterjee, Siddharth Sarkar, Brahm Prakash   +3 more
doaj   +1 more source

Actin cytoskeleton-dependent regulation of corticotropin-releasing factor receptor heteromers [PDF]

, 2017
Stress responses are highly nuanced and variable, but how this diversity is achieved by modulating receptor function is largely unknown. Corticotropin-releasing factor receptors (CRFRs), class B G protein–coupled receptors, are pivotal in mediating ...
Bhargava, Aditi, Burlingame, Alma, Chand, Shreya, Grammatopoulos, Dimitris K., Hasdemir, Burcu, Mahajan, Shilpi, Oses-Prieto, Juan, Woolley, Michael J.   +7 more
core   +1 more source

Free‐Form Microfluidic Microneedle Array Patches

Advanced Functional Materials, EarlyView.
Microfluidic microneedle array patches (MAPs) integrate hollow microneedles with embedded microfluidic channels, fabricated using high‐resolution 3D printing, to enable controlled transdermal delivery of liquid, mixed, or reconstituted therapeutics.
Ian A. Coates, Madison M. Driskill, Netra U. Rajesh, Gabriel Lipkowitz, Dan Ilyn, Yue Xu, Maria T. Dulay, Gunilla B. Jacobson, John R. Tumbleston, Jillian L. Perry, Shaomin Tian, Joseph M. DeSimone   +11 more
wiley   +1 more source

Stochastic Chemical Reactions in Micro-domains

, 2004
Traditional chemical kinetics may be inappropriate to describe chemical reactions in micro-domains involving only a small number of substrate and reactant molecules.
D. Holcman, Karlin S., Kleinrock L., Matkowsky B. J., Matthews G., Saaty T. L., Schuss Z., Z. Schuss   +7 more
core   +2 more sources

Multiscale Profiling of Nanoscale Metal‐Organic Framework Biocompatibility and Immune Interactions

Advanced Healthcare Materials, EarlyView.
A multi‐scale, hierarchical ‘Safety‐by‐Design’ pipeline combining machine learning, ex vivo human blood assays, and in vivo models enables the systematic immunotoxicity and biocompatibility profiling of nanoscale metal‐organic frameworks, accelerating their safe clinical translation. Abstract The clinical translation of metal‐organic frameworks (MOFs) –
Yunhui Zhuang, Bárbara B. Mendes, Dhruv Menon, Jhenifer Oliveira, Xu Chen, Fatma Demir Duman, João Conniot, Sergio Mercado, Xiewen Liu, Shi‐Yuan Zhang, João Conde, Rachel E. Hewitt, David Fairen‐Jimenez   +12 more
wiley   +1 more source

Agonists and Inhibitors of the cGAS-STING Pathway

Molecules
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is pivotal in immunotherapy. Several agonists and inhibitors of the cGAS-STING pathway have been developed and evaluated for the treatment of various diseases. The agonists
Xiaoxuan Yu, Linxiang Cai, Jingyue Yao, Cenming Li, Xiaoyong Wang   +4 more
doaj   +1 more source