Results 111 to 120 of about 419,324 (239)

Recent advances in PET measures of brain 5-HT release. [PDF]

J Cereb Blood Flow Metab
Agnorelli C, Garling HD, Paterson LM, Erritzoe D, Knudsen GM.   +4 more
europepmc   +1 more source

NIR‐Activatable Domino Cascade Catalysis Nanozyme Reactor for Multi‐Mechanism Synergistic Immunotherapy in Bladder Cancer

Advanced Science, EarlyView.
This study presents an intravesical delivery strategy of ferroptosis‐ and immunity‐inducing nanozyme‐loaded thermoresponsive hydrogels (FMCC@PNH) for enhanced bladder cancer therapy. Abstract Current intravesical therapies for bladder cancer after resection are limited by poor tissue penetration, off‐target effects, and insufficient efficacy.
Yongnan Jiang, Qingling Zhang, Yuhan Zhang, Xinlu Yu, Bo Jia, Yulong Dong, Yalong Wu, Kelong Fan, Xinquan Gu, Lei Ji, Wei Jiang, Bin Liu   +11 more
wiley   +1 more source

Genetically Encoded CB₂R-Based Fluorescent Sensor Enables Rapid Screening and Functional Assessment of Cannabinoid Modulators. [PDF]

Int J Mol Sci
Bhattacharjee P, Volesky PD, Shivshankar S, Puhl H, Iyer MR.   +4 more
europepmc   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Administrative costs of prior authorizations for glucagon-like peptide-1 agonists. [PDF]

J Manag Care Spec Pharm
Pham D, Duby JJ, Setoudeh S, Knox S, Leahy K, Cruz D, Cutler T.   +6 more
europepmc   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

The Buprenorphine Paradox: How Buprenorphine Triggers and Resolves Opioid Withdrawal. [PDF]

Addict Biol
Haghdoost M, LaBranche J, Roberts M, Li VW, Kim JJ, Wong JSH, Azar P.   +6 more
europepmc   +1 more source

Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

Advanced Science, EarlyView.
This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu, Jianlie Wu, Ziyi Xu, Yifei Pei, Zaiping Jing, Jian Zhou, Rui Feng, Junjun Liu   +7 more
wiley   +1 more source

Irgm1 Improves Postinfarction Cardiac Repair by Promoting Neutrophil Clearance and Efferocytosis

Advanced Science, EarlyView.
The Irgm1‐PDIA3 axis enhances post‐infarction cardiac repair by accelerating neutrophil clearance and facilitating efferocytosis. Irgm1 holds potential as a prognostic biomarker in MI, and LOC14 may represent a therapeutic option to improve cardiac repair, especially in cases of Irgm1 deficiency.
Zeng Wang, Lai Wei, Mingyang Wang, Shanjie Wang, Lili Xiu, Jiaxiang Sun, Rongzhe Lu, Yige Liu, Jiaxin Wang, Fengyi Liu, Weike Liu, Bo Yu, Yong Sun, Xueqin Gao, Shaohong Fang   +14 more
wiley   +1 more source

Single-position ligand modifications tune CB₂R activity by targeting the toggle switch. [PDF]

Chem Sci
Ganzoni RLZ, Kosar M, Han Y, Vitale RM, Amodeo P, Li X, Zha Z, Patej KJ, Kicin B, Strunden TEN, Reichert L, Gómez-Bouzó U, Perera TP, Atz K, Guba W, Bartelmus C, Bigler R, Tosatti P, Bachmann S, Hua T, Sykes DA, Veprintsev DB, Grether U, Carreira EM.   +23 more
europepmc   +1 more source