Frontiers in PharmacologyDiabetes mellitus is a prevalent chronic disease, often leading to complications, with chronic wounds being among the most challenging. Impairment of the CXCR4/CXCL12 signaling pathway, which plays a key role in cell mobilization, migration, and ...
Lingli Wang +4 more
doaj +1 more source
Unsettling the Hegemony of Intention: Agonistic Image Generation [PDF]
arXivCurrent image generation paradigms prioritize actualizing user intention - "see what you intend" - but often neglect the sociopolitical dimensions of this process. However, it is increasingly evident that image generation is political, contributing to broader social struggles over visual meaning.
arxiv
α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model
Advanced Science, EarlyView.A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro +14 more
wiley +1 more source
THE EFFECTS OF OPIATE RECEPTOR AGONISTS AND ANTAGONISTS ON THE STRESS‐INDUCED SECRETION OF CORTICOSTERONE IN MICE [PDF]
, 1979 A Gibson +3 more
openalex +1 more source
Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies
Advanced Science, EarlyView.Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu +7 more
wiley +1 more source
The muscarinic receptor of heart cell membranes Association with agonists, antagonists and antiarrhythmic agents [PDF]
, 1977 Daniel Cavey +2 more
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Advanced Science, EarlyView.Lactobacillus johnsonii and its associated purine metabolite inosine not only restrict systemic B cell differentiation, but also contribute to immune cell infiltration in the kidneys, thereby serving dual functions in mitigating the progression of systemic lupus erythematosus (SLE).
Lingyu Gao +15 more
wiley +1 more source
Selecting age-specific protocol for controlled ovarian hyperstimulation in IVF program with particular reference to advanced age group [PDF]
Al Ameen Journal of Medical Sciences, 2013 Aim: The present study was aimed at finding out the age specific best protocol for ovarian stimulation, particularly for advanced age group. Materials and Methods: This retrospective analysis was carried out from July 2005 to June 2009 in 617 cycles of ...
Anjana Ray Chaudhuri +1 more
doaj
Extracellular-to-intracellular signal transfer via G-proteins [PDF]
arXiv, 2005 We look at the problem of signal transduction by extracellular agonist binding to a receptor protein at the membrane (sensor) via binding of G-proteins (effectors) to a highly integrative target molecule, such as the second messenger cAMP (target). We explore the effects of binding times, effector assignment and effector pool size on the shape of the ...
arxiv
KINETICS OF AGONIST CONDUCTANCE CHANGES DURING HYPERPOLARIZATION AT FROG ENDPLATES [PDF]
, 1975 Paul R. Adams
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