Results 141 to 150 of about 512,073 (249)

Elective peri‐operative management of adults taking glucagon‐like peptide‐1 receptor agonists, glucose‐dependent insulinotropic peptide agonists and sodium‐glucose cotransporter‐2 inhibitors: a multidisciplinary consensus statement [PDF]

Kariem El‐Boghdadly, Jugdeep Dhesi, Philippa Fabb, Nicholas Levy, Dileep N. Lobo, Andrew McKechnie, Омар Мустафа, Philip Newland‐Jones, Anil Patel, Dimitri J. Pournaras, Ken Clare, Ketan Dhatariya   +11 more
openalex   +1 more source

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Comparison of the metabolome of follicular fluid in GnRH agonist versus antagonist protocols during in vitro fertilization cycles. [PDF]

J Ovarian Res
Sun C, Zhang S, Tang X, Han TL, He F.
europepmc   +1 more source

Persisting high rates of mental health disorders in patients in opioid agonist treatment—Results from a 6‐year longitudinal study

Michael Soyka, Gabi Koller, Wittchen Hans‐Ulrich, Gerhard Bühringer   +3 more
openalex   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Glucagon-like peptide-1 receptor agonists as potential preventive and therapeutic agents in ischemic stroke

Muhammad Ali, Meng Yang, Sarah Eide, Hong‐Shuo Sun, Tianru Jin, Zhong‐Ping Feng   +5 more
openalex   +1 more source

GnRH agonist improves pregnancy outcome in mice with induced adenomyosis by restoring endometrial receptivity

, 2018
Song Guo, Zhichao Li, Yan Li, Yijuan Sun, Yun Feng   +4 more
openalex   +2 more sources

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

Impact of MED12 mutation and CDK8 activity on uterine leiomyoma growth and response to gonadotropin-releasing hormone agonist treatment. [PDF]

PLoS One
Tanioka S, Asano R, Ota Y, Nagai K, Takenaka K, Mizushima T, Miyagi Y, Miyagi E.   +7 more
europepmc   +1 more source

Unique agonist-bound cannabinoid CB1 receptor conformations indicate agonist specificity in signaling

, 2007
Teodora Georgieva, Savitha Devanathan, Dagmar Stropova, Chad K. Park, Zdzislaw Salamon, Gordon Tollin, Victor J. Hruby, William R. Roeske, Henry I. Yamamura, Éva Varga   +9 more
openalex   +1 more source