Results 141 to 150 of about 1,168,781 (390)

Selective Lipolysis by Photoactivation of Chaperone‐Mediated Autophagy Using Adipocyte Membrane‐Coated Nanoparticle in Hydrogel

open access: yesAdvanced Materials, EarlyView.
Adipocyte membrane‐coated nanoparticles loaded with rosiglitazone in hydrogel offer an alternative approach to conventional obesity treatments. This system selectively targets adipocytes, inducing lipolysis by activating chaperone‐mediated autophagy through mild photothermal stimulation.
Jaehyun Choi   +8 more
wiley   +1 more source

Corrigendum: A TNFR2-specific TNF fusion protein with improved in vivo activity

open access: yesFrontiers in Immunology, 2023
Juan Gamboa Vargas   +20 more
doaj   +1 more source

Structure and Function of an Irreversible Agonist-β2 Adrenoceptor complex

open access: yesNature, 2010
G-protein-coupled receptors (GPCRs) are eukaryotic integral membrane proteins that modulate biological function by initiating cellular signalling in response to chemically diverse agonists.
D. Rosenbaum   +17 more
semanticscholar   +1 more source

Pharmacogenetics of β2-Agonists

open access: yesAllergology International, 2011
Short-acting β2-agonists (SABAs) and long-acting β2-agonists (LABAs) are both important for treatment of asthma and chronic obstructive pulmonary disease (COPD) because of their bronchodilator and bronchoprotective effects. However, the use of these agonists, at least for asthma, has generated some controversy because of their association with ...
openaire   +4 more sources

Vascularized and Perfusable Human Heart‐on‐a‐Chip Model Recapitulates Aspects of Myocardial Ischemia and Enables Analysis of Nanomedicine Delivery

open access: yesAdvanced Materials, EarlyView.
This novel 3D human ischemic heart‐on‐a‐chip, with perfusable vasculature directly interfaced with myocardial tissue, replicates key aspects of ischemic heart injury. It also demonstrates the targeted delivery and therapeutic efficacy of cardiac homing peptide‐conjugated liposomes, validating the platform for drug and nanomedicine screening in ...
Junyoung Kim   +14 more
wiley   +1 more source

The Vitamin Riboflavin and Its Derivative Lumichrome Activate the LasR Bacterial Quorum-Sensing Receptor

open access: yesMolecular Plant-Microbe Interactions, 2008
Many bacteria use quorum sensing (QS) as an intercellular signaling mechanism to regulate gene expression in local populations. Plant and algal hosts, in turn, secrete compounds that mimic bacterial QS signals, allowing these hosts to manipulate QS ...
Sathish Rajamani   +8 more
doaj   +1 more source

DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications

open access: yesAdvanced Materials, EarlyView.
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding   +5 more
wiley   +1 more source

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