Results 191 to 200 of about 430,987 (266)

Inhalable ROS‐Responsive Nanospray Activates PPAR‐γ to Restore Macrophage Mitochondrial Homeostasis and Attenuate Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
A nebulized nanoassembly alleviates radiation‐induced lung injury by reprogramming macrophages through coordinated ROS scavenging, NAD+ replenishment, and PPAR‐γ activation. Redox balance, mitochondrial homeostasis, and immune regulation are restored, revealing a microenvironment‐centered strategy for localized radioprotection.
Mingquan Gao, Xudong Yu, Ziqian Shang, Mengyao Tan, Xie Huang, Zaizhi Du, Xiaojiao Wang, Xinrui Yang, Ximei Luo, Weidong Wang, Rong Li, Shenglin Luo   +11 more
wiley   +1 more source

Advances in molecular innate immune regulation in the development and therapeutic strategies of allergic rhinitis vaccines. [PDF]

Front Immunol
Liu Y, Meng C, Sha J, Zhu D, Sun Q, Wu N.   +5 more
europepmc   +1 more source

8‐Oxoguanine Modified CircMTUS1 Drives PABPC1 Phase Separation to Promote Gastric Cancer Progression and Cisplatin Resistance via Autophagy

Advanced Science, EarlyView.
ABSTRACT Gastric cancer (GC) is a major global health concern, as its prevention and treatment remain significant challenges. The 8‐oxoguanine (o8G) modification of circRNAs, alongside their capacity to orchestrate liquid‐liquid phase separation (LLPS) and autophagy, plays a pivotal role in driving tumor progression and determining therapeutic outcomes.
Lei Peng, Lurong Li, Zhenghui Zhu, Chenyang Li, Huaiming Sang, Guoxin Zhang, Xuan Li, Yini Dang, Yuanyuan Li   +8 more
wiley   +1 more source

Computational Insights into the Activation Mechanism of CXCR4: Implications for the Design of Small Molecule Agonists. [PDF]

J Am Chem Soc
Zhou J, Liu X, Xu Y, Cruz A, An J, Warshel A, Huang Z.   +6 more
europepmc   +1 more source

Reframing Buprenorphine as a Pharmacologic Modifier of Opioid-Induced Respiratory Depression in the Fentanyl Era. [PDF]

Pharmaceuticals (Basel)
Bahji A, Ghauri I, Mathew N, Day N, Tanguay R.   +4 more
europepmc   +1 more source

Extended Endocrine Therapy and Survival for Breast Cancer Subtypes in Premenopausal Patients.

JAMA Netw Open
Valenza C, Zheng Y, Milano M, Berton Giachetti PPM, Trapani D, Giordano E, Guidi L, Boldrini L, Castellano G, Katrini J, Malagutti B, Antonarelli G, Etessami JD, Bianco N, Conforti F, Kirkner GJ, Sangalli C, Dibble KE, Fusco N, Colleoni M, Regan MM, Munzone E, Curigliano G, Partridge AH.   +23 more
europepmc   +1 more source

GLP-1 Receptor Agonist Associated Unmasking of Insulinoma. [PDF]

Eur J Case Rep Intern Med
Simonov E, Berger R, Shishkina O, Sivokha A, Cantrell D.   +4 more
europepmc   +1 more source

Evolving prokinetic therapy: New targets and therapeutic opportunities in gastrointestinal motility disorders. [PDF]

World J Gastrointest Pharmacol Ther
Goyal O, Chowdhary R, Sehgal T, Joshi T, Bhambri A, Rampurawala IM, Sohi GS, Das A, Arora K, Vuthaluru AR, Goyal MK.   +10 more
europepmc   +1 more source

Tim-3 agonist restrains ILC2 function and attenuates airway hyperreactivity via NLK pathway. [PDF]

Nat Commun
Sakano Y, Sakano K, Kokubo K, Hurrell BP, Shen S, Li X, Swamy GYS, Cain J, Kuchroo VK, Akbari O.   +9 more
europepmc   +1 more source