Results 231 to 240 of about 1,168,781 (390)

Effects of ouabain on contractile response to agonists and Na,K-ATPase activity in isolated guinea pig seminal vesicle

, 1976
Sumiko Gamo, Hideyuki Nakagawa, Noriyoshi Kajimoto, Aritomo Suzuki   +3 more
openalex   +1 more source

Differential effects of fluoride on adenylate cyclase activity and guanine nucleotide regulation of agonist high-affinity receptor binding [PDF]

, 1988
Jeffrey M. Stadel, Stanley T. Crooke
openalex   +1 more source

FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity.

Journal of the American Society of Nephrology, 2017
Xiaoxin X. Wang, Dong Wang, Yuhuan Luo, K. Myakala, E. Dobrinskikh, A. Rosenberg, Jonathan Levi, J. Kopp, A. Field, Ashley Hill, S. Lucia, L. Qiu, T. Jiang, Yingqiong Peng, D. Orlicky, Gabriela E Garcia, M. Herman-Edelstein, V. D’Agati, K. Henriksen, L. Adorini, M. Pruzanski, Cen Xie, K. Krausz, F. Gonzalez, S. Ranjit, A. Dvornikov, E. Gratton, M. Levi   +27 more
semanticscholar   +1 more source

Osteoblast‐CD4+ CTL Crosstalk Mediated by SIRT1/DAAM2 Axis Prevents Age‐Related Bone Loss

Advanced Science, EarlyView.
In the osteoblastic niche, SIRT1 activates and recruits CD4+ CTLs by increasing DAAM2 expression via EZH2 deacetylation and boosting the secretion of key chemokines, such as CCL3, CCL5, and CXCL10. Then, CD4+ CTL directly eliminates senescent osteoblasts in an MHC‐II‐dependent way, thereby slowing down the process of bone ageing and effectively ...
Bin Yang, Guofu Zhang, Yizhou Zhu, Jingcheng Wang, Xinmin Feng, Wenyong Fei, Jihang Dai, Le Hu, Yi Zhang, Jun Cai, Binjia Ruan, Yue Jin, Fanhao Wei, Gang Lu, Dongan Wang, Jason Pui Yin Cheung, Graham Ka Hon Shea, Hao Chen, Kelvin Wai Kwok Yeung, Lei Wang, Yongxiang Wang   +20 more
wiley   +1 more source

METTL3/ALKBH5‐Mediated N6‐Methyladenosine Modification Drives Macrophage M1 Polarization via the SLC15A3‐TASL‐IRF5 Signaling Axis in Psoriasis

Advanced Science, EarlyView.
m6A modification stabilizes Slc15a3 mRNA in macrophages, activating the SLC15A3‐TASL‐IRF5 axis and promoting psoriatic inflammation. Abstract Impaired N6‐methyladenosine (m6A) modification has been implicated in regulating various inflammatory diseases, but its role in psoriasis remains unclear.
Tao Huang, Shijun Chen, Ke Ding, Liyan Yuan, Weiqi Lv, Kechen Chen, Yuchen Liu, Dongzhao Ma, Xin Zhang, Xiaobo Wang, Guanzheng Luo, Bin Yang, Ying Lin, Zhili Rong   +13 more
wiley   +1 more source

Cryo-EM structures of a pentameric ligand-gated ion channel in liposomes. [PDF]

Elife
Dalal V, Tan BK, Xu H, Cheng WWL.
europepmc   +1 more source

Comparison of effects of a-adrenergic agonists and antagonists on spinal reflexes of acute and chronic spinal rats

, 1978
Kazuo Kawasaki, Akira Matsushita
openalex   +1 more source

Diminished agonist-stimulated inositol trisphosphate generation blocks stimulus-secretion coupling in mouse pancreatic acini during diet-induced experimental pancreatitis. [PDF]

, 1986
Robert E. Powers, Ashok K. Saluja, Mary Jane Houlihan, Michael L. Steer   +3 more
openalex   +1 more source

Ligilactobacillus Murinus and Lactobacillus Johnsonii Suppress Macrophage Pyroptosis in Atherosclerosis through Butyrate‐GPR109A‐GSDMD Axis

Advanced Science, EarlyView.
Oral aspirin administration induces intestinal expansion of Lactobacillus murinus and Lactobacillus johnsonii, which suppresses the progression of atherosclerosis. This microbial expansion significantly enhances butyrate production by providing lactate as a metabolic substrate, thereby fostering the growth of butyrate‐producing bacteria. Butyrate plays
Rui Hua, Ning Ding, Yiming Hua, Xiaoke Wang, Yu Xu, Xiangrui Qiao, Xue Shi, Ting Bai, Ying Xiong, Xiaozhen Zhuo, Chong Fan, Juan Zhou, Yue Wu, Junhui Liu, Zuyi Yuan, Ting Li   +15 more
wiley   +1 more source

A Contemporary Rationale for Agonism of the GIP Receptor in the Treatment of Obesity. [PDF]

Diabetes
Samms RJ, Sloop KW.
europepmc   +1 more source