Results 231 to 240 of about 1,200,697 (382)

Impact of estrogen receptor agonists and model of menopause on enzymes involved in brain metabolism, acetyl-CoA production and cholinergic function

, 2020
Ziv Z. Kirshner, Jeffrey Yao, Junyi Li, Tao Long, Doug Nelson, R.B. Gibbs   +5 more
openalex   +2 more sources

A Pharmacological Comparison of Two Isomeric Nicotinic Receptor Agonists: The Marine Toxin Isoanatabine and the Tobacco Alkaloid Anatabine [PDF]

, 2020
Hong Xing, Sunil Keshwah, Anne Rouchaud, William R. Kem   +3 more
openalex   +1 more source

FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity.

Journal of the American Society of Nephrology, 2017
Xiaoxin X. Wang, Dong Wang, Yuhuan Luo, K. Myakala, Evgenia Dobrinskikh, A. Rosenberg, Jonathan Levi, J. Kopp, A. Field, Ashley Hill, S. Lucia, L. Qiu, T. Jiang, Yingqiong Peng, D. Orlicky, Gabriela E Garcia, M. Herman-Edelstein, V. D’Agati, K. Henriksen, L. Adorini, M. Pruzanski, Cen Xie, K. Krausz, F. Gonzalez, S. Ranjit, A. Dvornikov, E. Gratton, M. Levi   +27 more
semanticscholar   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Systemic STING agonist therapy drives expression of interferon stimulated genes and downstream production of cytokines in dogs with solid tumors. [PDF]

J Immunother Cancer
Lenz JA, DiBona J, Atherton MJ, Roy-Ghanta S, Schmidt H, Hart T, Yu JW.   +6 more
europepmc   +1 more source

Efficacy and safety of iGlarLixi versus IDegLira in adults with type 2 diabetes inadequately controlled by glucagon‐like peptide‐1 receptor agonists: a systematic literature review and indirect treatment comparison [PDF]

, 2020
Philip Home, Vanita R. Aroda, Lawrence Blonde, Patricia Guyot, Alka Shaunik, Mir Sohail Fazeli, Hardik Goswami, Sanjay Kalra, Mir‐Masoud Pourrahmat   +8 more
openalex   +1 more source

Mechanical Environment Afforded by Engineered Hydrogel Critically Regulates Survival of Neural Stem Cells Transplanted in the Injured Spinal Cord via Piezo1‐Mediated Mechanotransduction

Advanced Science, EarlyView.
Neural stem cell transplantation shows promise for spinal cord repair, but poor graft survival limits therapeutic efficacy. This study demonstrates that increasing hydrogel stiffness from 10% to 16% concentration significantly enhances transplanted neural stem cell survival through Piezo1‐mediated mechanotransduction, revealing mechanical properties as
Hee Hwan Park, Yurim Kim, Byeong Seong Jang, Simay Genişcan, Dong Hoon Hwang, Yeojin Seo, Seung‐Ah Jee, Hyo Gyeong Seo, Hyung Soon Kim, Ariandokht Einisadr, Ho‐Jeong Kim, Seolhee Lee, Sangwoo Kwon, Kyung Sook Kim, Kang In Lee, Jae Young Lee, Joo Min Park, Young‐Min Kim, Soo‐Chang Song, Byung Gon Kim   +19 more
wiley   +1 more source

In Vitro Pharmacology of Mitragynine at α-Adrenoceptors. [PDF]

ACS Chem Neurosci
Chen Y, Seto J, Obeng S, Mottinelli M, Mukhopadhyay S, Tyagi R, Hampson AJ, McCurdy CR, McMahon LR, Moniri NH, Canal CE.   +10 more
europepmc   +1 more source

YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination

Advanced Science, EarlyView.
The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu, Wenzhi Du, Yongwen Luo, Jiageng Shi, Tianyun Liu, Meng Ji, Kangping Xiong, Siming Chen, Fenfang Zhou, Mingxing Li, Jingtian Yu, Gang Wang, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Kaiyu Qian   +16 more
wiley   +1 more source

Perioperative Glucagon-like Peptide-1 Receptor Agonist Use Is Associated With Lower Pseudoarthrosis Rates Following Long-Segment Spinal Deformity Correction: A Propensity-Matched Analysis. [PDF]

Global Spine J
Stump K, Kelleher S, Hannah TC, Patel N, Kanuparthi P, Vij R, Kim BS.   +6 more
europepmc   +1 more source