Results 231 to 240 of about 766,676 (298)

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination

Advanced Science, EarlyView.
This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang, Qianchun Wang, Keming Li, Guanshuo Hu, Ying Xin, Kai Tang, Bing Hu, Pengyu Du, Renwei Mao, Baohua Ji, Youhua Tan   +10 more
wiley   +1 more source

Comparative lobe-specific histomorphometric evaluation of pulmonary architecture, fibrosis, and alveolar macrophage distribution in swine raised under different management systems. [PDF]

Vet World
Chaiyawong N, Praditwattanakit N, Chamsodsai S, Jumnongprakhon P, Phoungpetchara I, Promsuban C.   +5 more
europepmc   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

GPCR-selective effects of endocytosis on cellular signaling through the cAMP/PKA cascade. [PDF]

J Biol Chem
Blythe EE, Fagan RR, von Zastrow M.
europepmc   +1 more source

Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity

Advanced Science, EarlyView.
This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao, Hong‐Yi Zhao, Chengyi Li, Hanning Wen, Fang Ke, Qiuxia Li, Miao He, Bo Wen, Zhongwei Liu, Kai Sun, Wei Gao, Duxin Sun   +11 more
wiley   +1 more source

The melanocortin receptors as targets for general obesity: contextualizing clinical failures and analyzing future perspectives. [PDF]

Front Endocrinol (Lausanne)
Prindle CR, Bennett TL, Rajewski BH, Kelley KJ, Impastato AC, Potterfield R, Marks DL, Delev JY.   +7 more
europepmc   +1 more source

Nano‐Enabled Systemic Delivery of STING Agonist by Engineered Silicasome for Potent Antitumor Immunotherapy

Advanced Science, EarlyView.
Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou, Yuting Li, Xudong Sun, Honghong Yang, Xiayu Shi, Lijia Yao, Jinhong Jiang, Erli Wang, Haoyang Wang, Yi Wei, Xiangsheng Liu   +10 more
wiley   +1 more source

Engineering polymeric RNA scaffolds as programmable combinatorial innate immune agonists. [PDF]

Nucleic Acids Res
Yang Y, Alvarez AK, Wang W, Issa ECD, Dorsey E, Wu C.   +5 more
europepmc   +1 more source

PARP7 inhibition and a STING agonist potentiate radiation-induced immunogenicity in glioblastoma. [PDF]

Oncoimmunology
Lippert L, Kleinwächter A, Ohradanova-Repic A, Horvat F, Appel LM, Walch L, Bragato N, Wimmer J, Wopfner H, Röhrer A, Engl M, Upadhyaya K, Widder J, Cohen MS, Slade D.   +14 more
europepmc   +1 more source

TLR8 agonists remodel the tumor immune microenvironment through PF4-dependent T cell recruitment and ancillary mechanisms. [PDF]

Cancer Immunol Immunother
Zhou Q, Wang Z, Cao Y, Zheng Z, Li W, Fu Z, Luo W, Gao WQ, Ma B.   +8 more
europepmc   +1 more source