Results 261 to 270 of about 1,168,781 (390)

Capsaicin Alleviates Autophagy‐Lysosomal Dysfunction via PPARA‐Mediated V‐ATPase Subunit ATP6V0E1 Signaling in 3xTg‐AD Mice

Advanced Science, EarlyView.
Capsaicin enhances lipid metabolism, reduces lipid deposition, and alleviates AD‐related pathologies. Capsaicin activates PPARA, promoting the expression of PPAR signaling pathway‐related genes and accelerating lipid metabolism. Capsaicin upregulates ATP6V0E1‐V‐ATPase‐mediated lysosomal acidification, enhancing lipid droplet clearance. PPARA is the key
Haitao Yu, Jia Chen, Fangzhou Wang, Dongdong Jia, Shuguang Bi, Yuming Mao, Yu‐qi Zhang, Tian‐long Gao, Liu Yang, Jia‐xu Du, Zi‐han Zhou, Xi‐Chen Zhu, Gao‐shang Chai   +12 more
wiley   +1 more source

Cannabinoids and alcohol co-exposure modulate pathogen-induced pulmonary immune responses. [PDF]

Front Immunol
Parker D, Sivaraman V.
europepmc   +1 more source

Pharmacodynamic Studies with a Specific α2-Adrenoceptor Agonist (BHT-933) in Man

, 1982
Peter C. Rubin, Colin W. Howden, Kathleen McLean, John L. Reid   +3 more
openalex   +1 more source

Mesencephalic Astrocyte‐Derived Neurotrophic Factor Binds BAX to Preserve Mitochondrial Homeostasis and Energy Metabolism for Relieving Myocardial Hypertrophy

Advanced Science, EarlyView.
MANF in cardiomyocytes interacts with BAX to impede BAX mitochondrial translocation and cytochrome c release, further stabilizing mitochondrial structure and energy supply to relieve myocardial apoptosis and hypertrophy, which indicates MANF as a novel cardioprotective factor to have a promising clinical application for myocardial hypertrophy ...
Dong Wang, Xinru Zhang, Baolong Wang, Haipeng Li, Dongshuo Xu, Yun Yang, Jialu Zhang, Wenbing Wang, Ren Zhang, Xinyu Wang, Yunfeng Cai, Shiyu Cao, Chao Hou, Changhui Wang   +13 more
wiley   +1 more source

Effect of Glucagon-Like Peptide 1 Receptor Agonists on Obstructive Sleep Apnea. [PDF]

Obes Sci Pract
Qian BB, Huang YJ, Yan CF, Feng SY, She DM.   +4 more
europepmc   +1 more source

Reports of pathological gambling, hypersexuality, and compulsive shopping associated with dopamine receptor agonist drugs.

JAMA Internal Medicine, 2014
T. Moore, Joseph Glenmullen, D. Mattison
semanticscholar   +1 more source

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source

The human STING agonist E7766 induces immunogenic tumor clearance, independent of tumor-intrinsic STING expression in the <i>KRAS^G12D/+ Trp53^-/-</i> murine model of sarcoma. [PDF]

Oncoimmunology
Hildebrand KM, Hildebrand KN, Salazar Arcila C, Marritt K, Rajwani J, Elmi Assadzadeh G, Dufour A, Jirik FR, Monument MJ.   +8 more
europepmc   +1 more source

Effects of adrenoceptor agonists and antagonists on the firing of neurons in the rat A1 noradrenergic region.

, 1986
Hideto Kaba, Hideo Saitô, Kuniaki Otsuka, Katsuo Seto   +3 more
openalex   +2 more sources

Gonadotropin-releasing hormone agonist versus HCG for oocyte triggering in antagonist-assisted reproductive technology.

Cochrane Database of Systematic Reviews, 2014
M. A. Youssef, F. van der Veen, H. Al-Inany, M. Mochtar, G. Griesinger, Mohamed Nagi Mohesen, Ismail Aboulfoutouh, M. van Wely   +7 more
semanticscholar   +1 more source