Results 261 to 270 of about 1,200,697 (382)

Thyroid Hormone Receptor β1 and PGC1α Coordinately Regulate OPA1/MFN2‐Mediated Mitochondrial Fusion and UCP1‐Mediated Lipid Browning in ccRCC

Advanced Science, EarlyView.
Thyroid hormone receptor β1 (TRβ) downregulation correlates with poor prognosis in clear cell renal cell carcinoma (ccRCC). Restoration of TRβ and the peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha suppresses tumor progression in ccRCC through Uncoupling protein 1 mediated tumor cell “slimming” and optic atrophy 1/mitofusin 2 ...
Xiangui Meng, Tiexi Yu, Fang Lv, Weiquan Li, Hongmei Yang, Xiaoping Zhang, Wen Xiao   +6 more
wiley   +1 more source

GLP-1 agonists in the treatment of chronic kidney disease in type 2 diabetes and obesity. [PDF]

J Clin Invest
Cooper ME, van Raalte DH.
europepmc   +1 more source

Structure of an Agonist-Bound Human A2A Adenosine Receptor

Science, 2011
Fei Xu, Huixian Wu, V. Katritch, G. Han, K. Jacobson, Zhang-Guo Gao, V. Cherezov, R. Stevens   +7 more
semanticscholar   +1 more source

Microvascular Health as a Key Determinant of Organismal Aging

Advanced Science, EarlyView.
This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during aging. By combining basic angioscience concepts with a critical analysis of innovative pre‐clinical aging models and lifestyle interventions, it offers a ...
Mattia Cenciarini, Andrea Uccelli, Francesca Mangili, Myriam Grunewald, Simone Bersini   +4 more
wiley   +1 more source

Peptide vaccine formulations with structurally distinct STING agonist drugamers induce discrete, efficacious antitumor responses. [PDF]

Proc Natl Acad Sci U S A
Song K, Nguyen DC, Wang Y, Jokonya S, Yazdani O, Sellers DL, Stayton PS, Pun SH.   +7 more
europepmc   +1 more source

Discovery of Potent and Orally Bioavailable GPR40 Full Agonists Bearing Thiophen-2-ylpropanoic Acid Scaffold

, 2017
He Li, Qi Huang, Cheng Chen, Bin Xu, Heyao Wang, Ya‐Qiu Long   +5 more
openalex   +1 more source

Nanoparticle‐Modified Nanofibers Induce Ferroptosis and Stimulate Antitumor Immunity for Melanoma Therapy

Advanced Science, EarlyView.
This study presents a nanoparticle‐embedded nanofiber (5F/STFM/R‐ES) to inhibit melanoma growth and reduce the risk of metastasis and recurrence. The drug delivery system induces ferroptosis and potentiates immunotherapy through resiquimod (R848) and Fe/Mn‐based metal‐polyphenol networks (TFM).
Mingyang Li, Rongrong Li, Baotong Xu, Yuhan Lian, Chenyu Yang, Jingwen Li, Junhao Liang, Linhan Ding, Dongsheng Zhang, Jing Guo, Xiao Fu   +10 more
wiley   +1 more source

Molecular Dynamics Insights into TAS1R2 Transmembrane Domain Activation. [PDF]

Int J Mol Sci
Lu Y, Ma X, Meng Z, Cui M.
europepmc   +1 more source

The 5-hydroxytryptamine(4a) receptor is palmitoylated at two different sites and acylation is critically involved in regulation of receptor constitutive activity [PDF]

, 2002
Bickmeyer, Ulf, Dumuis, A., Heine, M., Loubert, L., Ponimaskin, E. G., Richter, D. W., Sebben, M.   +6 more
core  

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source